Eptaplatin

Product Name: Eptaplatin
CAS No.: 146665-77-2
Chemical Name: Eptaplatin
Synonyms: SUNPLA;SKI 2053R;EPTAPLATIN;heptaplatin;(SP-4-2)-[(4R,5R;EPOXYPROGESTERONE;Eptaplatin, >=98%;EPTAPLATIN, SUNPLA;Eptaplatin(SKI-2053R);Eptaplatin(Heptaplatin)
CBNumber: CB2717771
Molecular Formula: C11H20N2O6Pt
Formula Weight: 471.36
MOL File: 146665-77-2.mol

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Eptaplatin Property

Melting point:: 43-49°C
storage temp.: Refrigerator, Under Inert Atmosphere
solubility: DMSO (Slightly), Water (Slightly, Heated)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E591500
Product name: Eptaplatin
Packaging: 50mg
Price: $910
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002576
Product name: EPTAPLATIN
Purity: 95.00%
Packaging: 0.025G
Price: $1044
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FE22772
Product name: Eptaplatin
Packaging: 10mg
Price: $95
Updated: 2021/12/16

AK Scientific

Product number: N771
Product name: Eptaplatin
Packaging: 5mg
Price: $158
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FE22772
Product name: Eptaplatin
Packaging: 50mg
Price: $333
Updated: 2021/12/16

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Eptaplatin Chemical Properties,Usage,Production

Description

SKI-2053R was launched in Korea for the treatment of patients with advanced gastric adenocarcinoma. It is a third generation platinum complex alkylating agent with less nephrotoxicity than cisplatin. In in vitro experiments, SKI-2053R was highly active against various cell lines including cisplatinresistant tumor cell lines. In mice implanted with L1210 cells, SKI-2053R showed activity comparable or superior to cisplatin or carboplatin. In mice implanted s.c. with human tumor xenograft KATO III (stomach adenocarcinoma), SKI-2053R achieved growth-inhibition rates comparable with those of cisplatin. General pharmacological studies in animals did not display any severe adverse effects on the different systems at antitumour doses. Pharmacokinetic studies after a single iv administration in rats demonstrated that the compound was extensively and rapidly distributed into all tissues except the CNS. In patients with unresectable or metastatic gastric adenocarcinoma, SKI-2053R was active without significant hematological toxicity. Phase III trials with SKI-2053R are currently ongoing for the treatment of various other cancers including lung, head and neck.

Chemical Properties

White Crystalline Powder

Originator

SK Pharma (Korea)

Uses

A coordination compound for treatment of cervix cancer.

brand name

Sunpla

Pharmaceutical Applications

heptaplatin is further examples of platinum-based agents being used in China and South Korea, respectively. Heptaplatin is used in South Korea to treat gastric cancer. It show the typical side effects such as myelosuppression and mild hepatotoxicity. its success is limited and has not led to approval in the EU or by the FDA.

Eptaplatin Preparation Products And Raw materials

Raw materials

Preparation Products

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Eptaplatin Suppliers

Canada 1 China 55 Europe 2 Germany 1 Japan 1 South Korea 1 United Kingdom 6 United States 19 Global 86

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35906
Advantage: 56

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 0712-0712-2580635 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8849
Advantage: 52

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3750
Advantage: 55

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10658
Advantage: 60

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4951
Advantage: 58

Watson Biotechnology Co.,Ltd

Tel: 027-027-59207879 18140587686
Fax: QQ：1972026995
Email: kf@3600chem.com
Country: China
ProdList: 4699
Advantage: 55

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View Lastest Price from Eptaplatin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Eptaplatin 146665-77-2
Price: US $0.00/g
Min. Order: 1g
Purity: 98%-102%
Supply Ability: 100g
Release date: 2022-12-29

Zhuozhou Wenxi import and Export Co., Ltd

Product: Eptaplatin 146665-77-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Eptaplatin 146665-77-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

146665-77-2, EptaplatinRelated Search:

Cisplatin Carboplatin cis-Diamminediiodoplatinum Nedaplatin LOBAPLATIN DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Picoplatin Satraplatin (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate DIBROMO(1,5-CYCLOOCTADIENE)PLATINUM(II) Platinum Malonic acid (4R,5R)-4,5-BIS(AMINOMETHYL)-2-ISOPROPYL-1,3-DIOXOLANE Eptaplatin

SUNPLA

[sp-4-2-[4r-(2a,4a,5b)]]-[2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-n,n'][propanedioato(2-)-o,o']-platinum

heptaplatin

EPTAPLATIN

SKI 2053R

EPOXYPROGESTERONE

(SP-4-2)-[(4R,5R)-2-ISOPROPYL-1,3-DIOXOLANE-4,5-BIS(METHANAMINE)-N,N''][PROPANEDIOATO(2-)-O,O'']PLATINUM

(SP-4-2)-[(4R,5R)-2-(1-Methylethyl-1,3-dioxolane 4,5-dimethanamine-kN4,kN5][propanedioato(2-)-kO1,kO3]platinum

cis-[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](malonate)platinum(II)

(SP-4-2)-[(4R,5R)-2-Isopropyl-1,3-dioxolane-4,5-

EPTAPLATIN, SUNPLA

Eptaplatin(Heptaplatin)

Eptaplatin(SKI-2053R)

Eptaplatin, >=98%

(SP-4-2)-[(4R,5R

cis-[(4R,5R)-2-Isopropyl-1,3-dioxolane-4,5-bis(methylamine)-N,N'][malonato(2-)-O,O']platinum

Cis-(1,3-malanato)-[(4R,5R)-4,5-bis(aminomethyl)-2isopropyl-1,3-dioxolane]platinum(II)

cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)}

9-propan-2-yl-8,10-dioxa-3,5-diaza-4$l^{4}-platinabicyclo[5.3.0]deca-3,4-diene

cis-[2-Isopropyl-1,3-dioxolane-4,5-bis(methylamine)-N,N][malonato(2-)-O,O]platinum

Heptaplatin (SKI-2053R)

146665-77-2

C11H20N2O6Pt

C8H18N2O2C3H2O4Pt

C11H16N2O6Pt

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Heterocyclic Compounds

Anticancer