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Eptaplatin

Product Name
Eptaplatin
CAS No.
146665-77-2
Chemical Name
Eptaplatin
Synonyms
SUNPLA;SKI 2053R;EPTAPLATIN;heptaplatin;(SP-4-2)-[(4R,5R;EPOXYPROGESTERONE;Eptaplatin, >=98%;EPTAPLATIN, SUNPLA;Eptaplatin(SKI-2053R);Eptaplatin(Heptaplatin)
CBNumber
CB2717771
Molecular Formula
C11H20N2O6Pt
Formula Weight
471.36
MOL File
146665-77-2.mol
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Eptaplatin Property

Melting point:
43-49°C
storage temp. 
Refrigerator, Under Inert Atmosphere
solubility 
DMSO (Slightly), Water (Slightly, Heated)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
E591500
Product name
Eptaplatin
Packaging
50mg
Price
$910
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002576
Product name
EPTAPLATIN
Purity
95.00%
Packaging
0.025G
Price
$1044
Updated
2021/12/16
Biosynth Carbosynth
Product number
FE22772
Product name
Eptaplatin
Packaging
10mg
Price
$95
Updated
2021/12/16
AK Scientific
Product number
N771
Product name
Eptaplatin
Packaging
5mg
Price
$158
Updated
2021/12/16
Biosynth Carbosynth
Product number
FE22772
Product name
Eptaplatin
Packaging
50mg
Price
$333
Updated
2021/12/16
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Eptaplatin Chemical Properties,Usage,Production

Description

SKI-2053R was launched in Korea for the treatment of patients with advanced gastric adenocarcinoma. It is a third generation platinum complex alkylating agent with less nephrotoxicity than cisplatin. In in vitro experiments, SKI-2053R was highly active against various cell lines including cisplatinresistant tumor cell lines. In mice implanted with L1210 cells, SKI-2053R showed activity comparable or superior to cisplatin or carboplatin. In mice implanted s.c. with human tumor xenograft KATO III (stomach adenocarcinoma), SKI-2053R achieved growth-inhibition rates comparable with those of cisplatin. General pharmacological studies in animals did not display any severe adverse effects on the different systems at antitumour doses. Pharmacokinetic studies after a single iv administration in rats demonstrated that the compound was extensively and rapidly distributed into all tissues except the CNS. In patients with unresectable or metastatic gastric adenocarcinoma, SKI-2053R was active without significant hematological toxicity. Phase III trials with SKI-2053R are currently ongoing for the treatment of various other cancers including lung, head and neck.

Chemical Properties

White Crystalline Powder

Originator

SK Pharma (Korea)

Uses

A coordination compound for treatment of cervix cancer.

brand name

Sunpla

Pharmaceutical Applications

heptaplatin is further examples of platinum-based agents being used in China and South Korea, respectively. Heptaplatin is used in South Korea to treat gastric cancer. It show the typical side effects such as myelosuppression and mild hepatotoxicity. its success is limited and has not led to approval in the EU or by the FDA.

Eptaplatin Preparation Products And Raw materials

Raw materials

Preparation Products

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Eptaplatin Suppliers

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View Lastest Price from Eptaplatin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Eptaplatin 146665-77-2
Price
US $0.00/g
Min. Order
1g
Purity
98%-102%
Supply Ability
100g
Release date
2022-12-29
Zhuozhou Wenxi import and Export Co., Ltd
Product
Eptaplatin 146665-77-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Eptaplatin 146665-77-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

146665-77-2, EptaplatinRelated Search:

Cisplatin Carboplatin cis-Diamminediiodoplatinum Nedaplatin LOBAPLATIN DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Picoplatin Satraplatin (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate DIBROMO(1,5-CYCLOOCTADIENE)PLATINUM(II) Platinum Malonic acid (4R,5R)-4,5-BIS(AMINOMETHYL)-2-ISOPROPYL-1,3-DIOXOLANE Eptaplatin

  • SUNPLA
  • [sp-4-2-[4r-(2a,4a,5b)]]-[2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-n,n'][propanedioato(2-)-o,o']-platinum
  • heptaplatin
  • EPTAPLATIN
  • SKI 2053R
  • EPOXYPROGESTERONE
  • (SP-4-2)-[(4R,5R)-2-ISOPROPYL-1,3-DIOXOLANE-4,5-BIS(METHANAMINE)-N,N''][PROPANEDIOATO(2-)-O,O'']PLATINUM
  • (SP-4-2)-[(4R,5R)-2-(1-Methylethyl-1,3-dioxolane 4,5-dimethanamine-kN4,kN5][propanedioato(2-)-kO1,kO3]platinum
  • cis-[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](malonate)platinum(II)
  • (SP-4-2)-[(4R,5R)-2-Isopropyl-1,3-dioxolane-4,5-
  • EPTAPLATIN, SUNPLA
  • Eptaplatin(Heptaplatin)
  • Eptaplatin(SKI-2053R)
  • Eptaplatin, >=98%
  • (SP-4-2)-[(4R,5R
  • cis-[(4R,5R)-2-Isopropyl-1,3-dioxolane-4,5-bis(methylamine)-N,N'][malonato(2-)-O,O']platinum
  • Cis-(1,3-malanato)-[(4R,5R)-4,5-bis(aminomethyl)-2isopropyl-1,3-dioxolane]platinum(II)
  • cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)}
  • 9-propan-2-yl-8,10-dioxa-3,5-diaza-4$l^{4}-platinabicyclo[5.3.0]deca-3,4-diene
  • cis-[2-Isopropyl-1,3-dioxolane-4,5-bis(methylamine)-N,N][malonato(2-)-O,O]platinum
  • Heptaplatin (SKI-2053R)
  • 146665-77-2
  • C11H20N2O6Pt
  • C8H18N2O2C3H2O4Pt
  • C11H16N2O6Pt
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Heterocyclic Compounds
  • Anticancer