ChemicalBook > CAS DataBase List > Eptaplatin

Eptaplatin

Product Name: Eptaplatin
CAS No.: 146665-77-2
Chemical Name: Eptaplatin
Synonyms: SUNPLA;SKI 2053R;EPTAPLATIN;heptaplatin;(SP-4-2)-[(4R,5R;EPOXYPROGESTERONE;Eptaplatin, >=98%;EPTAPLATIN, SUNPLA;Eptaplatin(SKI-2053R);Eptaplatin(Heptaplatin)
CBNumber: CB2717771
Molecular Formula: C11H20N2O6Pt
Formula Weight: 471.36
MOL File: 146665-77-2.mol

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Eptaplatin Property

Melting point:: 43-49°C
storage temp.: Refrigerator, Under Inert Atmosphere
solubility: DMSO (Slightly), Water (Slightly, Heated)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E591500
Product name: Eptaplatin
Packaging: 50mg
Price: $910
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002576
Product name: EPTAPLATIN
Purity: 95.00%
Packaging: 0.025G
Price: $1044
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FE22772
Product name: Eptaplatin
Packaging: 10mg
Price: $95
Updated: 2021/12/16

AK Scientific

Product number: N771
Product name: Eptaplatin
Packaging: 5mg
Price: $158
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FE22772
Product name: Eptaplatin
Packaging: 50mg
Price: $333
Updated: 2021/12/16

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Eptaplatin Chemical Properties,Usage,Production

Description

SKI-2053R was launched in Korea for the treatment of patients with advanced gastric adenocarcinoma. It is a third generation platinum complex alkylating agent with less nephrotoxicity than cisplatin. In in vitro experiments, SKI-2053R was highly active against various cell lines including cisplatinresistant tumor cell lines. In mice implanted with L1210 cells, SKI-2053R showed activity comparable or superior to cisplatin or carboplatin. In mice implanted s.c. with human tumor xenograft KATO III (stomach adenocarcinoma), SKI-2053R achieved growth-inhibition rates comparable with those of cisplatin. General pharmacological studies in animals did not display any severe adverse effects on the different systems at antitumour doses. Pharmacokinetic studies after a single iv administration in rats demonstrated that the compound was extensively and rapidly distributed into all tissues except the CNS. In patients with unresectable or metastatic gastric adenocarcinoma, SKI-2053R was active without significant hematological toxicity. Phase III trials with SKI-2053R are currently ongoing for the treatment of various other cancers including lung, head and neck.

Chemical Properties

White Crystalline Powder

Originator

SK Pharma (Korea)

Uses

A coordination compound for treatment of cervix cancer.

brand name

Sunpla

Pharmaceutical Applications

heptaplatin is further examples of platinum-based agents being used in China and South Korea, respectively. Heptaplatin is used in South Korea to treat gastric cancer. It show the typical side effects such as myelosuppression and mild hepatotoxicity. its success is limited and has not led to approval in the EU or by the FDA.

Eptaplatin Preparation Products And Raw materials

Raw materials

Preparation Products

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Eptaplatin Suppliers

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View Lastest Price from Eptaplatin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Eptaplatin 146665-77-2
Price: US $0.00/g
Min. Order: 1g
Purity: 98%-102%
Supply Ability: 100g
Release date: 2022-12-29

Zhuozhou Wenxi import and Export Co., Ltd

Product: Eptaplatin 146665-77-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Eptaplatin 146665-77-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

146665-77-2, EptaplatinRelated Search:

Cisplatin Carboplatin cis-Diamminediiodoplatinum Nedaplatin LOBAPLATIN DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Picoplatin Satraplatin (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate DIBROMO(1,5-CYCLOOCTADIENE)PLATINUM(II) Platinum Malonic acid (4R,5R)-4,5-BIS(AMINOMETHYL)-2-ISOPROPYL-1,3-DIOXOLANE Eptaplatin

SUNPLA

[sp-4-2-[4r-(2a,4a,5b)]]-[2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-n,n'][propanedioato(2-)-o,o']-platinum

heptaplatin

EPTAPLATIN

SKI 2053R

EPOXYPROGESTERONE

(SP-4-2)-[(4R,5R)-2-ISOPROPYL-1,3-DIOXOLANE-4,5-BIS(METHANAMINE)-N,N''][PROPANEDIOATO(2-)-O,O'']PLATINUM

(SP-4-2)-[(4R,5R)-2-(1-Methylethyl-1,3-dioxolane 4,5-dimethanamine-kN4,kN5][propanedioato(2-)-kO1,kO3]platinum

cis-[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](malonate)platinum(II)

(SP-4-2)-[(4R,5R)-2-Isopropyl-1,3-dioxolane-4,5-

EPTAPLATIN, SUNPLA

Eptaplatin(Heptaplatin)

Eptaplatin(SKI-2053R)

Eptaplatin, >=98%

(SP-4-2)-[(4R,5R

cis-[(4R,5R)-2-Isopropyl-1,3-dioxolane-4,5-bis(methylamine)-N,N'][malonato(2-)-O,O']platinum

Cis-(1,3-malanato)-[(4R,5R)-4,5-bis(aminomethyl)-2isopropyl-1,3-dioxolane]platinum(II)

cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)}

9-propan-2-yl-8,10-dioxa-3,5-diaza-4$l^{4}-platinabicyclo[5.3.0]deca-3,4-diene

cis-[2-Isopropyl-1,3-dioxolane-4,5-bis(methylamine)-N,N][malonato(2-)-O,O]platinum

Heptaplatin (SKI-2053R)

Eptaplatin, Heptaplatin, Sunpla

146665-77-2

C11H20N2O6Pt

C8H18N2O2C3H2O4Pt

C11H16N2O6Pt

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Heterocyclic Compounds

Anticancer