7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-one

Product Name: 7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-one
CAS No.: 321436-06-0
Chemical Name: 7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-one
Synonyms: 7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-one;BUTTPARK 120;BUTTPARK 120\07-73;7-Bromo-4H-1,4-benzoxazin-3-one;7-BroMo-4H-benzo[1,4]oxazin-3-one;7-BROMO-2H-1,4-BENZOXAZIN-3(4H)-ONE;7-Bromo-2H-benzo[b][1,4]oxazin-3(4H);2H-1,4-Benzoxazin-3(4H)-one, 7-bromo-;-broMo-2H-benzo[b][1,4]oxazin-3(4H)-one;7-broMo-3,4-dihydro-2H-1,4-benzoxazin-3-one
CBNumber: CB2681195
Molecular Formula: C8H6BrNO2
Formula Weight: 228.04
MOL File: 321436-06-0.mol

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7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-one Property

Boiling point:: 381.5±42.0 °C(Predicted)
Density: 1.676
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 11.76±0.20(Predicted)
Appearance: Light brown to brown Solid
InChI: InChI=1S/C8H6BrNO2/c9-5-1-2-6-7(3-5)12-4-8(11)10-6/h1-3H,4H2,(H,10,11)
InChIKey: ZAXUQDMKVBOVCR-UHFFFAOYSA-N
SMILES: O1C2=CC(Br)=CC=C2NC(=O)C1

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B680433
Product name: 7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-one
Packaging: 1g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB156376
Product name: 7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-one
Packaging: 250mg
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: J99391
Product name: 7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-one
Packaging: 1g
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB156376
Product name: 7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-one
Packaging: 500mg
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB156376
Product name: 7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-one
Packaging: 1g
Price: $120
Updated: 2021/12/16

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7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-one Chemical Properties,Usage,Production

Uses

7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-one is used in the pharmaceutical field as an anticancer agent component, and in organic synthesis as a synthetic reaction reagent or intermediate component.

Synthesis

38191-34-3

79-04-9

321436-06-0

2. 2-Amino-5-bromophenol (2.53 g, 18.2 mmol, 1.0 eq.) was dissolved in a solvent mixture of 15 mL of isobutylmethyl ketone and 15 mL of water, and cooled to 0 °C. Subsequently, NaHCO3 (3.67 g, 2.4 eq.) and chloroacetyl chloride (2.36 g, 1.67 mL, 1.15 eq.) were added. The reaction mixture was heated to reflux and stirred overnight, then cooled to room temperature. After completion of the reaction, the mixture was diluted with ethyl acetate, washed sequentially with water, dried with MgSO4 and finally concentrated under vacuum. Purification by silica gel column chromatography afforded 7-bromo-3,4-dihydro-2H-1,4-benzoxazin-3-one in 77% yield. After analyzed by low resolution mass spectrometry (LRMS), the molecular ion peak (M + H)+ was measured to be 180.1, which was consistent with the theoretical value of C9H10NO3.

References

[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 1, p. 222 - 236
[2] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 5, p. 592 - 597
[3] MedChemComm, 2015, vol. 6, # 7, p. 1375 - 1380
[4] ChemMedChem, 2015, vol. 10, # 11, p. 1821 - 1836
[5] Patent: US6534535, 2003, B1

7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-one Suppliers

China 129 Germany 1 India 2 United Kingdom 4 United States 6 Global 142

Shanghai Kahn Pharmaceutical Co., Ltd.

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View Lastest Price from 7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-one manufacturers

Career Henan Chemical Co

Product: BUTTPARK 120\07-73 321436-06-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-08

Career Henan Chemical Co

Product: BUTTPARK 120\07-73 321436-06-0
Price: US $6.60/KG
Min. Order: 1KG
Purity: 98%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-07

321436-06-0, 7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-oneRelated Search:

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BUTTPARK 120\07-73

-broMo-2H-benzo[b][1,4]oxazin-3(4H)-one

7-broMo-3,4-dihydro-2H-1,4-benzoxazin-3-one

7-BROMO-2H-1,4-BENZOXAZIN-3(4H)-ONE

7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)-one

BUTTPARK 120

7-BroMo-4H-benzo[1,4]oxazin-3-one

7-Bromo-4H-1,4-benzoxazin-3-one

7-Bromo-2H-benzo[b][1,4]oxazin-3(4H)

2H-1,4-Benzoxazin-3(4H)-one, 7-bromo-

321436-06-0