7-bromo-2-chloroquinazoline

Uses

Product Name: 7-bromo-2-chloroquinazoline
CAS No.: 953039-66-2
Chemical Name: 7-bromo-2-chloroquinazoline
Synonyms: 2-chloro-7-bromoquinazoline;7-bromo-2-chloroquinazoline;7-BroMo-2-chloroquinazoli...;Quinazoline, 7-broMo-2-chloro-
CBNumber: CB71856179
Molecular Formula: C8H4BrClN2
Formula Weight: 243.49
MOL File: 953039-66-2.mol

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7-bromo-2-chloroquinazoline Property

Boiling point:: 309.7±24.0 °C(Predicted)
Density: 1.762±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.51±0.30(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C8H4BrClN2/c9-6-2-1-5-4-11-8(10)12-7(5)3-6/h1-4H
InChIKey: LEVIQMAFISIVMA-UHFFFAOYSA-N
SMILES: N1=C2C(C=CC(Br)=C2)=CN=C1Cl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B684728
Product name: 7-Bromo-2-chloroquinazoline
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB42506
Product name: 7-Bromo-2-chloroquinazoline
Packaging: 250mg
Price: $80
Updated: 2021/12/16

Matrix Scientific

Product number: 072534
Product name: 7-Bromo-2-chloroquinazoline
Purity: 95+%
Packaging: 250mg
Price: $82
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB42506
Product name: 7-Bromo-2-chloroquinazoline
Packaging: 500mg
Price: $125
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB42506
Product name: 7-Bromo-2-chloroquinazoline
Packaging: 100mg
Price: $50
Updated: 2021/12/16

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7-bromo-2-chloroquinazoline Chemical Properties,Usage,Production

Uses

7-Bromo-2-chloroquinazoline is a heterocyclic derivative and is mainly used as a pharmaceutical intermediate.

Synthesis

953039-65-1

953039-66-2

Step 5. Synthesis of 7-bromo-2-chloroquinazoline: A suspension of 7-bromoquinazolin-2(1H)-one (0.5 M) in phosphoryl chloride was placed in an oil bath, heated to 110 °C and maintained for 1 hour. After completion of the reaction, the mixture was cooled to room temperature. Subsequently, the volatiles were removed under reduced pressure. The residue was ground with ice water and the resulting solid was collected by filtration and dried in air to afford the target product 7-bromo-2-chloroquinazoline in 65% yield. The product was analyzed by electrospray mass spectrometry (ES/MS) and showed m/z of 243/245 (MH+).

References

[1] Patent: WO2007/117607, 2007, A2. Location in patent: Page/Page column 334
[2] Patent: WO2017/32840, 2017, A1. Location in patent: Page/Page column 258
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 24, p. 6829 - 6833

7-bromo-2-chloroquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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7-bromo-2-chloroquinazoline Suppliers

China 125 India 2 United Kingdom 1 United States 11 Global 139

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View Lastest Price from 7-bromo-2-chloroquinazoline manufacturers

Career Henan Chemical Co

Product: 7-bromo-2-chloroquinazoline 953039-66-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-02

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