7-Bromoquinazoline

Product Name: 7-Bromoquinazoline
CAS No.: 89892-22-8
Chemical Name: 7-Bromoquinazoline
Synonyms: 7-Bromoquizoline;7-BROMO-QUINAZOLINE;Quinazoline, 7-bromo-
CBNumber: CB9850631
Molecular Formula: C8H5BrN2
Formula Weight: 209.04
MOL File: 89892-22-8.mol

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7-Bromoquinazoline Property

Boiling point:: 304.3±15.0 °C(Predicted)
Density: 1.656±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 3.60±0.70(Predicted)
Appearance: White to yellow Solid

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Safety

Risk Statements: 41
Safety Statements: 26-39

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B687990
Product name: 7-Bromoquinazoline
Packaging: 10mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB42451
Product name: 7-Bromoquinazoline
Packaging: 250mg
Price: $250
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-9-34
Product name: 7-Bromoquinazoline
Purity: 95%
Packaging: 1g
Price: $280
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB42451
Product name: 7-Bromoquinazoline
Packaging: 500mg
Price: $350
Updated: 2021/12/16

Matrix Scientific

Product number: 068398
Product name: 7-Bromoquinazoline
Purity: >95%
Packaging: 250mg
Price: $492
Updated: 2021/12/16

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7-Bromoquinazoline Chemical Properties,Usage,Production

Uses

7-Bromoquinazoline has been used as a reactant in the preparation of N1-(5-(heterocyclyl)-thiazol-2-yl)-3-(4-trifluoromethylphenyl)-1,2-propanediamines as AKT/PKB inhibitors for cancer treatment.

Synthesis

253-82-7

89892-22-8

General procedure for the synthesis of 7-bromoquinazoline from quinazoline: Step A: N-bromosuccinimide (NBS, 2.13 g, 11.9 mmol) was slowly added to a solution of concentrated sulfuric acid (appropriate amount) of compound 214 (quinazoline, 1.04 g, 7.99 mmol) at room temperature. The reaction mixture was stirred continuously at room temperature for 16 h. The reaction progress was monitored by thin layer chromatography (TLC, unfolding agent: 5% methanol/dichloromethane) to confirm the completion of the reaction. Subsequently, the reaction mixture was carefully poured into crushed ice (~50 mL) and the pH was adjusted to neutral (pH=7) using ammonium hydroxide solution. The resulting slurry was continued to be stirred at 0 °C for 1 h. The solid product was then collected by filtration and washed with ice-cold water (3 x 30 mL). Finally, purification by silica gel column chromatography (SiO2, eluent: 5% methanol/dichloromethane) afforded the target compound 215 (7-bromoquinazoline) as a beige solid with a yield of 0.53 g in 32% yield. Product characterization: 1H NMR (400 MHz, DMSO-d6) δ 9.57 (s, 1H), 9.32 (s, 1H), 8.46 (d, 1H), 8.14 (dd, 1H), 7.96 (d, 1H).

References

[1] Patent: WO2008/82487, 2008, A2. Location in patent: Page/Page column 106
[2] Synthesis, 2002, # 1, p. 83 - 86

7-Bromoquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Bromoquinazoline Suppliers

China 89 Germany 1 India 1 United Kingdom 2 United States 14 Global 107

J & K SCIENTIFIC LTD.

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SpringPharma Tech Co.,Ltd

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Shanghai yirong biology science and technology co., ltd

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View Lastest Price from 7-Bromoquinazoline manufacturers

Career Henan Chemical Co

Product: 7-Bromoquinazoline 89892-22-8
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-08-05

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89892-22-8

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