7-Bromo-2-chloroquinoxaline
Uses- Product Name
- 7-Bromo-2-chloroquinoxaline
- CAS No.
- 89891-65-6
- Chemical Name
- 7-Bromo-2-chloroquinoxaline
- Synonyms
- Ethyl vanillin 121-32-4;3-chloro-6-bromoquinoxaline;7-BROMO-2-CHLOROQUINOXALINE;Quinoxaline, 7-bromo-2-chloro-
- CBNumber
- CB7696729
- Molecular Formula
- C8H4BrClN2
- Formula Weight
- 243.49
- MOL File
- 89891-65-6.mol
7-Bromo-2-chloroquinoxaline Property
- Boiling point:
- 312.5±37.0 °C(Predicted)
- Density
- 1.762
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.50±0.30(Predicted)
- Appearance
- Off-white to light brown Solid
- InChI
- InChI=1S/C8H4BrClN2/c9-5-1-2-6-7(3-5)12-8(10)4-11-6/h1-4H
- InChIKey
- AZUMKBQKUXTHCM-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=C(Br)C=2)N=CC=1Cl
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B684848
- Product name
- 7-Bromo-2-chloroquinoxaline
- Packaging
- 5g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 073000
- Product name
- 7-Bromo-2-chloroquinoxaline
- Purity
- 95+%
- Packaging
- 5g
- Price
- $163
- Updated
- 2021/12/16
- Product number
- 3H32-D-5H
- Product name
- 7-Bromo-2-chloroquinoxaline
- Purity
- 97%
- Packaging
- 5G
- Price
- $207
- Updated
- 2021/12/16
- Product number
- FB42449
- Product name
- 7-Bromo-2-chloroquinoxaline
- Packaging
- 250mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- OR952570
- Product name
- 7-Bromo-2-chloroquinoxaline
- Purity
- 97%
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
7-Bromo-2-chloroquinoxaline Chemical Properties,Usage,Production
Uses
7-Bromo-2-chloroquinoxaline is a heterocyclic derivative that can be used as an organic intermediate.
Synthesis
82031-32-1
89891-65-6
General procedure for the synthesis of 7-bromo-2-chloroquinoxaline from 7-bromo-2(1H)-quinoxalinone: 7-bromoquinoxalin-2-ol (2 g, 8.88 mmol) was added to dry phosphorus trichloride (7 mL) to form a suspension, followed by the addition of N,N-dimethylformamide (DMF, 2 drops). The reaction mixture was heated to 100 °C and the reaction was stirred at this temperature for 3 hours. After completion of the reaction, the mixture was cooled to room temperature. Excess phosphorous trichloride was evaporated under reduced pressure and the residue was dissolved in ethyl acetate (EtOAc) and added slowly dropwise to ice water under stirring. The aqueous phase was extracted three times with ethyl acetate, the organic layers were combined and washed with saturated sodium bicarbonate (NaHCO3) solution. Finally, the organic layer was concentrated to give 7-bromo-2-chloroquinoxaline as a solid product in 93% (2 g) yield.
References
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4735 - 4751
[2] Patent: WO2012/34526, 2012, A1. Location in patent: Page/Page column 34-35
[3] Patent: US2013/190307, 2013, A1. Location in patent: Paragraph 0162; 0164
[4] Patent: WO2017/32840, 2017, A1. Location in patent: Page/Page column 280
[5] Patent: WO2014/151147, 2014, A1. Location in patent: Paragraph 00641
7-Bromo-2-chloroquinoxaline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-Bromo-2-chloroquinoxaline manufacturers
- Product
- 7-Bromo-2-chloroquinoxaline 89891-65-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- 7-Bromo-2-chloroquinoxaline 89891-65-6
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-15
- Product
- 7-Bromo-2-chloroquinoxaline 89891-65-6
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 100kg
- Release date
- 2019-12-20