ChemicalBook > CAS DataBase List > 7-Bromo-2-chloroquinoxaline

7-Bromo-2-chloroquinoxaline

Uses

Product Name: 7-Bromo-2-chloroquinoxaline
CAS No.: 89891-65-6
Chemical Name: 7-Bromo-2-chloroquinoxaline
Synonyms: Ethyl vanillin 121-32-4;3-chloro-6-bromoquinoxaline;7-BROMO-2-CHLOROQUINOXALINE;Quinoxaline, 7-bromo-2-chloro-
CBNumber: CB7696729
Molecular Formula: C8H4BrClN2
Formula Weight: 243.49
MOL File: 89891-65-6.mol

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7-Bromo-2-chloroquinoxaline Property

Boiling point:: 312.5±37.0 °C(Predicted)
Density: 1.762
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -2.50±0.30(Predicted)
Appearance: Off-white to light brown Solid
InChI: InChI=1S/C8H4BrClN2/c9-5-1-2-6-7(3-5)12-8(10)4-11-6/h1-4H
InChIKey: AZUMKBQKUXTHCM-UHFFFAOYSA-N
SMILES: N1C2C(=CC=C(Br)C=2)N=CC=1Cl

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B684848
Product name: 7-Bromo-2-chloroquinoxaline
Packaging: 5g
Price: $140
Updated: 2021/12/16

Matrix Scientific

Product number: 073000
Product name: 7-Bromo-2-chloroquinoxaline
Purity: 95+%
Packaging: 5g
Price: $163
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-D-5H
Product name: 7-Bromo-2-chloroquinoxaline
Purity: 97%
Packaging: 5G
Price: $207
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB42449
Product name: 7-Bromo-2-chloroquinoxaline
Packaging: 250mg
Price: $210
Updated: 2021/12/16

Apolloscientific

Product number: OR952570
Product name: 7-Bromo-2-chloroquinoxaline
Purity: 97%
Packaging: 1g
Price: $39
Updated: 2021/12/16

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7-Bromo-2-chloroquinoxaline Chemical Properties,Usage,Production

Uses

7-Bromo-2-chloroquinoxaline is a heterocyclic derivative that can be used as an organic intermediate.

Synthesis

82031-32-1

89891-65-6

General procedure for the synthesis of 7-bromo-2-chloroquinoxaline from 7-bromo-2(1H)-quinoxalinone: 7-bromoquinoxalin-2-ol (2 g, 8.88 mmol) was added to dry phosphorus trichloride (7 mL) to form a suspension, followed by the addition of N,N-dimethylformamide (DMF, 2 drops). The reaction mixture was heated to 100 °C and the reaction was stirred at this temperature for 3 hours. After completion of the reaction, the mixture was cooled to room temperature. Excess phosphorous trichloride was evaporated under reduced pressure and the residue was dissolved in ethyl acetate (EtOAc) and added slowly dropwise to ice water under stirring. The aqueous phase was extracted three times with ethyl acetate, the organic layers were combined and washed with saturated sodium bicarbonate (NaHCO3) solution. Finally, the organic layer was concentrated to give 7-bromo-2-chloroquinoxaline as a solid product in 93% (2 g) yield.

References

[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4735 - 4751
[2] Patent: WO2012/34526, 2012, A1. Location in patent: Page/Page column 34-35
[3] Patent: US2013/190307, 2013, A1. Location in patent: Paragraph 0162; 0164
[4] Patent: WO2017/32840, 2017, A1. Location in patent: Page/Page column 280
[5] Patent: WO2014/151147, 2014, A1. Location in patent: Paragraph 00641

7-Bromo-2-chloroquinoxaline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7-Bromo-2-chloroquinoxaline manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 7-Bromo-2-chloroquinoxaline 89891-65-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

Henan Fengda Chemical Co., Ltd

Product: 7-Bromo-2-chloroquinoxaline 89891-65-6
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-15

Career Henan Chemical Co

Product: 7-Bromo-2-chloroquinoxaline 89891-65-6
Price: US $2.00/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 100kg
Release date: 2019-12-20

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89891-65-6