ChemicalBook > CAS DataBase List > 6-Fluoro-2-oxindole

6-Fluoro-2-oxindole

Product Name
6-Fluoro-2-oxindole
CAS No.
56341-39-0
Chemical Name
6-Fluoro-2-oxindole
Synonyms
6-FLUOROOXINDOLE;BUTTPARK 24\07-31;6-Fluoro-2-oxindole;6-Fluorooxindole97%;6-Fluorooxindole 97%;6-Fluoro-2-oxoindole;6-FLUORO-2-OXYINDOLE;6-fluoroindolin-2-one;Sunitinib Impurity 48;1H-indol-6-yl hypofluorite
CBNumber
CB2682112
Molecular Formula
C8H6FNO
Formula Weight
151.14
MOL File
56341-39-0.mol
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6-Fluoro-2-oxindole Property

Melting point:
132-136°C
Boiling point:
287.5±40.0 °C(Predicted)
Density 
1.311±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
form 
solid
pka
13.37±0.20(Predicted)
color 
pink
InChI
InChI=1S/C8H6FNO/c9-6-2-1-5-3-8(11)10-7(5)4-6/h1-2,4H,3H2,(H,10,11)
InChIKey
PKQNTFAOZIVXCE-UHFFFAOYSA-N
SMILES
N1C2=C(C=CC(F)=C2)CC1=O
CAS DataBase Reference
56341-39-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,C,Xn
Risk Statements 
36/37/38-34-22
Safety Statements 
26-36/37/39-45-27
Hazard Note 
Irritant/Keep Cold
HS Code 
2933790090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
F595013
Product name
6-Fluorooxindole
Packaging
500mg
Price
$65
Updated
2021/12/16
SynQuest Laboratories
Product number
4H48-3-X6
Product name
6-Fluorooxindole
Purity
97%
Packaging
250mg
Price
$28
Updated
2021/12/16
AK Scientific
Product number
J55602
Product name
6-Fluorooxindole
Packaging
1g
Price
$30
Updated
2021/12/16
AK Scientific
Product number
N499
Product name
6-Fluorooxindole
Packaging
1g
Price
$41
Updated
2021/12/16
Apolloscientific
Product number
PC1736
Product name
6-Fluorooxindole
Purity
97%
Packaging
1g
Price
$60
Updated
2021/12/16
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6-Fluoro-2-oxindole Chemical Properties,Usage,Production

Uses

6-Fluorooxindole, also known as 6-Fluoro-2-oxindole, is a fluorinated organic heterocyclic compound that can be used in the preparation of pharmaceutical and chemical products.

Synthesis

39616-95-0

56341-39-0

The general procedure for the synthesis of 6-fluoroindolin-2-one from 2-(4-fluoro-2-nitrophenyl)acetic acid is as follows: 119 g of 2-(4-fluoro-2-nitrophenyl)acetic acid (Feedstock III) and 600 ml of acetic acid were added to a reactor followed by 20 g of palladium catalyst (loaded on 10% activated carbon). The hydrogenation reaction was carried out under hydrogen pressure of 50 psi. Upon completion of the reaction, the catalyst was removed by diafiltration, followed by removal of the solvent acetic acid by distillation. The crude product obtained was co-milled with 500 ml of petroleum ether, further separated by diafiltration, washed with water and dried. Finally 82.5 g of 6-fluoroindolin-2-one was obtained in 91% yield of the theoretical value. The product was detected by thin layer chromatography (TLC) with an Rf value of 0.30 (silica gel plate, unfolding agent was petroleum ether/ethyl acetate 1:1). Mass spectrometry analysis showed a molecular ion peak m/z = 150 [MH]-, which is consistent with the molecular weight of the target product C8H6FNO.

References

[1] Patent: US2005/43389, 2005, A1. Location in patent: Page/Page column 19
[2] Patent: WO2004/26829, 2004, A2. Location in patent: Page/Page column 80
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 14, p. 2588 - 2603
[4] Patent: US6878733, 2005, B1. Location in patent: Page/Page column 170
[5] Patent: US6350754, 2002, B2. Location in patent: Page column 21

6-Fluoro-2-oxindole Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Fluoro-2-oxindole Suppliers

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View Lastest Price from 6-Fluoro-2-oxindole manufacturers

Henan Fengda Chemical Co., Ltd
Product
6-Fluoro-2-oxindole 56341-39-0
Price
US $36.00-1.50/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
6-Fluoro-2-oxindole 56341-39-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
6-Fluoro-2-oxindole 56341-39-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

56341-39-0, 6-Fluoro-2-oxindoleRelated Search:

Indometacin Dihydromyrcenol Indole-3-butyric acid Indole-3-acetic acid Oxindole Fluorine 5,6-DIFLUOROISATIN 6-FLUOROISATIN 5,6-Difluoro-2-oxoindole 4,6-DIFLUOROOXINDOLE 4,6-DIFLUOROINDOLINE-2,3-DIONE 6-TRIFLUOROMETHYLOXINDOLE 5-Fluoro-2-Oxo-Indole 5-Trifluoromethyl-2-oxindole 6-Fluoroindole 5-chloro-6-fluoro-1H-indole-2,3-dione 6-Fluoro-7-Methyl Isatin 6-Fluoro-2-oxindole

  • 6-FLUOROOXINDOLE
  • BUTTPARK 24\07-31
  • 6-Fluoro-2-oxoindole
  • 6-Fluorooxindole 97%
  • 6-Fluorooxindole97%
  • 2H-Indol-2-one,6-fluoro-1,3-dihydro-(9CI)
  • 6-Fluoro-2-oxindole
  • 6-Fluoro-1,3-dihydro-2H-indol-2-one
  • 6-fluoroindolin-2-one
  • 6-Fluoro-1,3-dihydro-indol-2-one
  • 1H-indol-6-yl hypofluorite
  • 6-fluoro-2,3-dihydro-1H-indol-2-one
  • 6-FLUORO-2-OXYINDOLE
  • 6-Fluoro-2-oxindole in stock Factory
  • 2H-Indol-2-one, 6-fluoro-1,3-dihydro-
  • Sunitinib Impurity 48
  • 56341-39-0
  • INDOLE
  • blocks
  • FluoroCompounds
  • IndolesOxindoles
  • Indole/indoline/oxindole
  • Indole and Indoline
  • Indoles