6-Fluoro-2-oxindole
- Product Name
- 6-Fluoro-2-oxindole
- CAS No.
- 56341-39-0
- Chemical Name
- 6-Fluoro-2-oxindole
- Synonyms
- 6-FLUOROOXINDOLE;BUTTPARK 24\07-31;6-Fluoro-2-oxindole;6-Fluorooxindole97%;6-Fluorooxindole 97%;6-Fluoro-2-oxoindole;6-FLUORO-2-OXYINDOLE;6-fluoroindolin-2-one;Sunitinib Impurity 48;1H-indol-6-yl hypofluorite
- CBNumber
- CB2682112
- Molecular Formula
- C8H6FNO
- Formula Weight
- 151.14
- MOL File
- 56341-39-0.mol
6-Fluoro-2-oxindole Property
- Melting point:
- 132-136°C
- Boiling point:
- 287.5±40.0 °C(Predicted)
- Density
- 1.311±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- form
- solid
- pka
- 13.37±0.20(Predicted)
- color
- pink
- InChI
- InChI=1S/C8H6FNO/c9-6-2-1-5-3-8(11)10-7(5)4-6/h1-2,4H,3H2,(H,10,11)
- InChIKey
- PKQNTFAOZIVXCE-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC(F)=C2)CC1=O
- CAS DataBase Reference
- 56341-39-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,C,Xn
- Risk Statements
- 36/37/38-34-22
- Safety Statements
- 26-36/37/39-45-27
- Hazard Note
- Irritant/Keep Cold
- HS Code
- 2933790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F595013
- Product name
- 6-Fluorooxindole
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 4H48-3-X6
- Product name
- 6-Fluorooxindole
- Purity
- 97%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- PC1736
- Product name
- 6-Fluorooxindole
- Purity
- 97%
- Packaging
- 5g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 4H48-3-X6
- Product name
- 6-Fluorooxindole
- Purity
- 97%
- Packaging
- 250mg
- Price
- $28
- Updated
- 2021/12/16
- Product number
- J55602
- Product name
- 6-Fluorooxindole
- Packaging
- 1g
- Price
- $30
- Updated
- 2021/12/16
6-Fluoro-2-oxindole Chemical Properties,Usage,Production
Uses
6-Fluorooxindole, also known as 6-Fluoro-2-oxindole, is a fluorinated organic heterocyclic compound that can be used in the preparation of pharmaceutical and chemical products.
Synthesis
39616-95-0
56341-39-0
The general procedure for the synthesis of 6-fluoroindolin-2-one from 2-(4-fluoro-2-nitrophenyl)acetic acid is as follows: 119 g of 2-(4-fluoro-2-nitrophenyl)acetic acid (Feedstock III) and 600 ml of acetic acid were added to a reactor followed by 20 g of palladium catalyst (loaded on 10% activated carbon). The hydrogenation reaction was carried out under hydrogen pressure of 50 psi. Upon completion of the reaction, the catalyst was removed by diafiltration, followed by removal of the solvent acetic acid by distillation. The crude product obtained was co-milled with 500 ml of petroleum ether, further separated by diafiltration, washed with water and dried. Finally 82.5 g of 6-fluoroindolin-2-one was obtained in 91% yield of the theoretical value. The product was detected by thin layer chromatography (TLC) with an Rf value of 0.30 (silica gel plate, unfolding agent was petroleum ether/ethyl acetate 1:1). Mass spectrometry analysis showed a molecular ion peak m/z = 150 [MH]-, which is consistent with the molecular weight of the target product C8H6FNO.
References
[1] Patent: US2005/43389, 2005, A1. Location in patent: Page/Page column 19
[2] Patent: WO2004/26829, 2004, A2. Location in patent: Page/Page column 80
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 14, p. 2588 - 2603
[4] Patent: US6878733, 2005, B1. Location in patent: Page/Page column 170
[5] Patent: US6350754, 2002, B2. Location in patent: Page column 21
6-Fluoro-2-oxindole Preparation Products And Raw materials
Raw materials
Preparation Products
6-Fluoro-2-oxindole Suppliers
- Tel
- --
- Fax
- --
- sales@riccichimica.com
- Country
- Italy
- ProdList
- 2146
- Advantage
- 46
View Lastest Price from 6-Fluoro-2-oxindole manufacturers
- Product
- 6-Fluoro-2-oxindole 56341-39-0
- Price
- US $36.00-1.50/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 6-Fluoro-2-oxindole 56341-39-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 6-Fluoro-2-oxindole 56341-39-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09