2-Methylene-1,3-propanediol

Application

Product Name: 2-Methylene-1,3-propanediol
CAS No.: 3513-81-3
Chemical Name: 2-Methylene-1,3-propanediol
Synonyms: 2-Methylene-1;2-methylene-3-propanediol;1-（4-pyridinyl) acetone;2-methylenepropane-1,3-diol;2-METHYLENE-1,3-PROPANEDIOL;2-Methylidenepropane-1,3-diol;1,3-Propanediol, 2-methylene-;2-Methylene-1,3-propanediol>2-Methylene-1,3-propanediol 97%;2-METHYLENE-1,3-PROPANEDIOL,97+%
CBNumber: CB2684161
Molecular Formula: C4H8O2
Formula Weight: 88.11
MOL File: 3513-81-3.mol

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2-Methylene-1,3-propanediol Property

Boiling point:: 93-95 °C/2 mmHg (lit.)
Density: 1.081 g/mL at 25 °C (lit.)
refractive index: n20/D 1.473(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 14.14±0.10(Predicted)
form: Viscous Liquid
color: Clear colorless to pale yellow
BRN: 1737653
InChI: InChI=1S/C4H8O2/c1-4(2-5)3-6/h5-6H,1-3H2
InChIKey: JFFYKITVXPZLQS-UHFFFAOYSA-N
SMILES: C(O)C(=C)CO
CAS DataBase Reference: 3513-81-3(CAS DataBase Reference)
EPA Substance Registry System: 1,3-Propanediol, 2-methylene- (3513-81-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29053990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 339512
Product name: 2-Methylene-1,3-propanediol
Purity: 97%
Packaging: 5g
Price: $133.95
Updated: 2025/07/31

TCI Chemical

Product number: M2473
Product name: 2-Methylene-1,3-propanediol
Purity: >96.0%(GC)
Packaging: 1g
Price: $35
Updated: 2025/07/31

TCI Chemical

Product number: M2473
Product name: 2-Methylene-1,3-propanediol
Purity: >96.0%(GC)
Packaging: 5g
Price: $106
Updated: 2025/07/31

TRC

Product number: B494823
Product name: 2-Methylene-1,3-propanediol
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK193879
Product name: 2-Methylene-1,3-propanediol
Purity: 97%
Packaging: 1g
Price: $79
Updated: 2021/12/16

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2-Methylene-1,3-propanediol Chemical Properties,Usage,Production

Application

2-Methylene-1,3-propanediol, commonly known as isobutylene glycol, can be used to synthesize platelet-active factor inhibitors due to its unique methylene branched structure; it is also a crosslinking agent that can esterify with alkyd and polyester resins, effectively improving the thermal stability of polymers.

Chemical Properties

clear colorless to pale yellow viscous liquid

Synthesis

3775-29-9

3513-81-3

General procedure for the synthesis of 2-methylene-1,3-propanediol from 2-methylenepropane-1,3-diyl diacetate: allyl alcohol (1 eq.) was dissolved with acetic anhydride (1.2 eq.) in dichloromethane (DCM, concentration ca. 1 M) at 0 °C. Subsequently, pyridine (1 eq.) and 4-dimethylaminopyridine (DMAP, 0.1 mol%) were added to the reaction system. The reaction mixture was kept stirred at 0 °C for 30 min and then gradually warmed up to room temperature. After completion of the reaction, the reaction was quenched with 2N hydrochloric acid solution, the organic layer was separated, washed sequentially with water and brine and finally dried with anhydrous sodium sulfate. The solvent was removed by careful evaporation under reduced pressure to give pure 2-methylene propane-1,3-diyl diacetate (2d) without further purification. Subsequent processing was carried out via Method B. Specifically, purification by column chromatography (eluent ratio hexane:ethyl acetate = 20:1) afforded 2-methylene-1,3-propanediol as a colorless oil (20 g, 91% yield). The analytical data of the resulting compound were in agreement with literature reports.

References

[1] Patent: WO2018/53322, 2018, A1. Location in patent: Paragraph 0090; 00143
[2] J. Appl. Chem. USSR (Engl. Transl.), 1988, vol. 61, # 4, p. 853 - 855
[3] Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1988, vol. 61, # 4, p. 934 - 937
[4] Synlett, 2008, # 15, p. 2321 - 2325

2-Methylene-1,3-propanediol Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from 2-Methylene-1,3-propanediol manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Methylene-1,3-propanediol 3513-81-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

PNP Biotech Co. Ltd

Product: 2-Methylene-1,3-propanediol 3513-81-3
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%
Supply Ability: Inquiry
Release date: 2023-07-17

Career Henan Chemical Co

Product: 2-Methylene-1,3-propanediol 3513-81-3
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2019-08-31

3513-81-3, 2-Methylene-1,3-propanediolRelated Search:

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3513-81-3

CH2CCH2OH2

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