2-P-ANISYL-1,3-INDANDIONE
- Product Name
- 2-P-ANISYL-1,3-INDANDIONE
- CAS No.
- 117-37-3
- Chemical Name
- 2-P-ANISYL-1,3-INDANDIONE
- Synonyms
- andion;Miradon;spe2792;Unidone;SPE 2792;unidione;HSDB 3205;Andindione;Anisindone;nisindione
- CBNumber
- CB2689681
- Molecular Formula
- C16H12O3
- Formula Weight
- 252.26
- MOL File
- 117-37-3.mol
2-P-ANISYL-1,3-INDANDIONE Property
- Melting point:
- 156-157°
- Boiling point:
- 355.44°C (rough estimate)
- Density
- 1.1824 (rough estimate)
- refractive index
- 1.5600 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly)
- form
- Solid
- pka
- pKa 4.13(H2O t=25.0±0.1 I=0.1(NaCl)) (Uncertain)
- color
- White to Off-White
- EPA Substance Registry System
- Anisindione (117-37-3)
Safety
- RIDADR
- 2811
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 117-37-3(Hazardous Substances Data)
- Toxicity
- mouse,LD50,intraperitoneal,200mg/kg (200mg/kg),Journal of Medicinal Chemistry. Vol. 28, Pg. 1591, 1985.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H351Suspected of causing cancer
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P308+P313IF exposed or concerned: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A673480
- Product name
- Anisindione
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FA29786
- Product name
- Anisindione
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 063576
- Product name
- 2-(4-Methoxyphenyl)-1H-indene-1,3(2H)-dione
- Packaging
- 500mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- FA29786
- Product name
- Anisindione
- Packaging
- 2g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FA29786
- Product name
- Anisindione
- Packaging
- 5G
- Price
- $200
- Updated
- 2021/12/16
2-P-ANISYL-1,3-INDANDIONE Chemical Properties,Usage,Production
Chemical Properties
Slightly beige or yellow powder
Originator
Miradon,Schering,US,1960
Uses
radiopaque agent
Uses
Anisindione is a synthetic anticoagulant that prevents the formation of active procoagulation factors and proteins in the liver.
Definition
ChEBI: A cyclic beta-diketone consisting of indane-1,3-dione having a 4-methoxyphenyl substituent at the 4-position.
Manufacturing Process
To a hot solution of 20.6 g of sodium in 400 ml of absolute ethanol, there is added a solution of 110 g of phthalide and 110 g of p-methoxybenzaldehyde. A vigorous reaction ensues and one-half of the alcohol is distilled off over a two hour period. Ice and water are added to the red solution and the diluted solution is acidified with hydrochloric acid. The resulting gum solidifies and the aqueous phase is removed by decantation. The crude solid is recrystallized twice from two liters of ethanol yielding 2-(p-methoxyphenyl)-1,3-indandione as pale yellow crystals, MP 155-156°C.
brand name
Miradon (Schering).
Therapeutic Function
Anticoagulant
General Description
Anisindione, 2-(p-methoxyphenyl)-1,3-indandione, 2-(p-anisyl)-1,3-indandione (Miradon), is ap-methoxy congener of phenindione. It is a white, crystallinepowder, slightly soluble in water, tasteless, and absorbedwell after oral administration.
In instances when the urine may be alkaline, an orangecolor may be detected. This is caused by metabolic productsof anisindione and is not hematuria.
Purification Methods
Crystallise anisidinone from acetic acid or EtOH. [Horeau & Jacqius Bull Soc Chim Fr 53 1948, Koelsch J Am Chem. Soc 58 1331 1936, Beilstein 8 III 2931.]
2-P-ANISYL-1,3-INDANDIONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-P-ANISYL-1,3-INDANDIONE manufacturers
- Product
- 2-P-ANISYL-1,3-INDANDIONE 117-37-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-13