2-P-ANISYL-1,3-INDANDIONE

Product Name: 2-P-ANISYL-1,3-INDANDIONE
CAS No.: 117-37-3
Chemical Name: 2-P-ANISYL-1,3-INDANDIONE
Synonyms: andion;Miradon;spe2792;Unidone;SPE 2792;unidione;HSDB 3205;Andindione;Anisindone;nisindione
CBNumber: CB2689681
Molecular Formula: C16H12O3
Formula Weight: 252.26
MOL File: 117-37-3.mol

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2-P-ANISYL-1,3-INDANDIONE Property

Melting point:: 156-157°
Boiling point:: 355.44°C (rough estimate)
Density: 1.1824 (rough estimate)
refractive index: 1.5600 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly)
form: Solid
pka: pKa 4.13(H2O t=25.0±0.1 I=0.1(NaCl)) (Uncertain)
color: White to Off-White
EPA Substance Registry System: Anisindione (117-37-3)

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Safety

RIDADR: 2811
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 117-37-3(Hazardous Substances Data)
Toxicity: mouse,LD50,intraperitoneal,200mg/kg (200mg/kg),Journal of Medicinal Chemistry. Vol. 28, Pg. 1591, 1985.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H351Suspected of causing cancer

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P308+P313IF exposed or concerned: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A673480
Product name: Anisindione
Packaging: 1g
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA29786
Product name: Anisindione
Packaging: 1g
Price: $70
Updated: 2021/12/16

Matrix Scientific

Product number: 063576
Product name: 2-(4-Methoxyphenyl)-1H-indene-1,3(2H)-dione
Packaging: 500mg
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA29786
Product name: Anisindione
Packaging: 2g
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA29786
Product name: Anisindione
Packaging: 5G
Price: $200
Updated: 2021/12/16

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2-P-ANISYL-1,3-INDANDIONE Chemical Properties,Usage,Production

Chemical Properties

Slightly beige or yellow powder

Originator

Miradon,Schering,US,1960

Uses

radiopaque agent

Uses

Anisindione is a synthetic anticoagulant that prevents the formation of active procoagulation factors and proteins in the liver.

Definition

ChEBI: A cyclic beta-diketone consisting of indane-1,3-dione having a 4-methoxyphenyl substituent at the 4-position.

Manufacturing Process

To a hot solution of 20.6 g of sodium in 400 ml of absolute ethanol, there is added a solution of 110 g of phthalide and 110 g of p-methoxybenzaldehyde. A vigorous reaction ensues and one-half of the alcohol is distilled off over a two hour period. Ice and water are added to the red solution and the diluted solution is acidified with hydrochloric acid. The resulting gum solidifies and the aqueous phase is removed by decantation. The crude solid is recrystallized twice from two liters of ethanol yielding 2-(p-methoxyphenyl)-1,3-indandione as pale yellow crystals, MP 155-156°C.

brand name

Miradon (Schering).

Therapeutic Function

Anticoagulant

General Description

Anisindione, 2-(p-methoxyphenyl)-1,3-indandione, 2-(p-anisyl)-1,3-indandione (Miradon), is ap-methoxy congener of phenindione. It is a white, crystallinepowder, slightly soluble in water, tasteless, and absorbedwell after oral administration.
In instances when the urine may be alkaline, an orangecolor may be detected. This is caused by metabolic productsof anisindione and is not hematuria.

Purification Methods

Crystallise anisidinone from acetic acid or EtOH. [Horeau & Jacqius Bull Soc Chim Fr 53 1948, Koelsch J Am Chem. Soc 58 1331 1936, Beilstein 8 III 2931.]

2-P-ANISYL-1,3-INDANDIONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-P-ANISYL-1,3-INDANDIONE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-P-ANISYL-1,3-INDANDIONE 117-37-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-13

117-37-3, 2-P-ANISYL-1,3-INDANDIONERelated Search:

Anethole trithione Indene 1H-Indene-1,3(2H)-dione, 2-hydroxy-2-(2-hydroxy-4,5-dimethoxyphenyl)- 1,3-Indandione, 2-(3,4-dimethoxy-2-hydroxyphenyl)-2-hydroxy- 2-BENZYL-2-(4-METHOXYPHENYL)-1H-INDENE-1,3(2H)-DIONE 2-P-ANISYL-1,3-INDANDIONE 1,3-Indandione, 2-hydroxy-2-(2-hydroxy-4,5,6-trimethoxyphenyl)- 2-Hydroxy-2-(2-hydroxy-4-methoxyphenyl)-1H-indene-1,3(2H)-dione 2-BROMO-2-(4-METHOXYPHENYL)INDANE-1,3-DIONE

ANISINDIONE

2-P-ANISYL-1,3-INDANDIONE

1,3-Indandione, 2-(p-methoxyphenyl)-

1H-Indene-1,3(2H)-dione, 2-(4-methoxyphenyl)-

2-(4-Methoxyphenyl)-1H-indene-1,3(2H)-dione

2-(4-methoxyphenyl)indan-1,3-dione

2-(p-Methoxyphenyl)-1,3-indandione

2-(p-methoxyphenyl)-3-indandione

2-(p-Methoxyphenyl)indane-1,3-dione

2-para-anisyl-1,3-indandione

andion

Anisin indandione

anisinindandione

Miradon

SPE 2792

spe2792

unidione

Unidone

Andindione

Anisindone

2-(4-methoxyphenyl)indane-1,3-quinone

2-(4-methoxyphenyl)indene-1,3-dione

1,3-Indanedione, 2-(4-methoxyphenyl)-

2-(4-methoxyphenyl)indane-1,3-dione

Anisindione≥ 98% (TLC)

2-(4-methoxyphenyl)-1h-indene-3(2h)-dione

2-(4-methoxyphenyl)-3-indanedione

HSDB 3205

nisindione

Anisindione,inhibit,Inhibitor

117-37-3

Inhibitors

OPTIRAY