2-Chloropropiophenone
- Product Name
- 2-Chloropropiophenone
- CAS No.
- 6084-17-9
- Chemical Name
- 2-Chloropropiophenone
- Synonyms
- 2-CHLORO-1-PHENYLPROPAN-1-ONE;2-CHLOROPROPIOPHENONE;2-Chloropropiophenone >2-CHLORO-1-PHENYL-1-PROPANONE;1-(2-Chlorophenyl)-1-propanone;1-Propanone,2-chloro-1-phenyl-;1-Propanone, 2-chloro-1-phenyl- (9CI)
- CBNumber
- CB2690429
- Molecular Formula
- C9H9ClO
- Formula Weight
- 168.62
- MOL File
- 6084-17-9.mol
2-Chloropropiophenone Property
- Melting point:
- 213-214 °C
- Boiling point:
- 80 °C(Press: 0.3 Torr)
- Density
- 1.560 g/cm3(Temp: 25 °C)
- refractive index
- 1.5430-1.5470
- form
- clear liquid
- color
- Colorless to Light yellow to Light orange
- InChI
- InChI=1S/C9H9ClO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7H,1H3
- InChIKey
- AXCPQHPNAZONTH-UHFFFAOYSA-N
- SMILES
- C(C1=CC=CC=C1)(=O)C(Cl)C
- CAS DataBase Reference
- 6084-17-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C1647
- Product name
- 2-Chloropropiophenone
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $138
- Updated
- 2025/07/31
- Product number
- C1647
- Product name
- 2-Chloropropiophenone
- Purity
- >95.0%(GC)
- Packaging
- 25g
- Price
- $484
- Updated
- 2025/07/31
- Product number
- C429333
- Product name
- 2-Chloropropiophenone
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 5584AL
- Product name
- 2-Chloropropiophenone
- Packaging
- 25g
- Price
- $496
- Updated
- 2021/12/16
- Product number
- K0440264
- Product name
- 2-chloro-1-phenylpropan-1-one
- Packaging
- 1g
- Price
- $661
- Updated
- 2021/12/16
2-Chloropropiophenone Chemical Properties,Usage,Production
Synthesis Reference(s)
The Journal of Organic Chemistry, 28, p. 630, 1963 DOI: 10.1021/jo01038a007
Synthesis
Step 1: Preparation of allylsilane ether: add phenylacetone (1 g, 8 mmol) to a 50 mL two-necked flask, and cool the solution to 0 ?? under nitrogen protection, then add 10 mL of anhydrous THF solution, then add lithium diisopropylammonium (2 mol/L, 4.2 mL) drop by drop to it, and when the addition is completed, remove the ice-water mixture used for cooling, and stir the solution at room temperature for 1 h. When the solution turns yellow, add trimethylchlorosilane (1.04 g, 9.6 mmol) to it drop by drop, and then add the lithium chlorotrimethylsilane (1.04 g, 9.6 mmol) to it. When the solution turned yellow, the reaction mixture was cooled to 0 ?? again, to which trimethylchlorosilane (1.04 g, 9.6 mmol) was added dropwise with stirring at room temperature and detected by TLC until the end of the reaction. The solvent was removed by distillation under reduced pressure and the final oily liquid was separated by column chromatography (pure petroleum ether) to give product 1a (1.3 g, yield: 84%).
Step 2: Preparation of α-chloropropiophenone: To a 50 mL two-necked vial was added iodobenzene diacetate (2a) (0.244 g, 0.75 mmol) protected by nitrogen, then phenylpropiophenone enol silane (1a) (0.096 g, 0.5 mmol) and trimethylchlorosilane (3a) (0.108 g, 1 mmol) of MeCN (5 mL) solution was added to the system. The reaction system was allowed to stir at room temperature and detected by TLC until the reaction was complete. After removal of the solvent by distillation under reduced pressure, the residue was separated by column chromatography [V(petroleum ether):V(ethyl acetate) = 10:1]. Final isolation gave the product 4l (α-chloropropiophenone) as a colorless liquid in 84% yield.
2-Chloropropiophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloropropiophenone manufacturers
- Product
- 2-Chloropropiophenone 6084-17-9
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25
- Product
- 2-Chloropropiophenone 6084-17-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-11-15
- Product
- 1-(2-Chlorophenyl)-1-propanone 6084-17-9
- Price
- US $30.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2023-10-07