2-Bromo-3'-chloropropiophenone

Product Name: 2-Bromo-3'-chloropropiophenone
CAS No.: 34911-51-8
Chemical Name: 2-Bromo-3'-chloropropiophenone
Synonyms: 2-BROMO-1-(3-CHLOROPHENYL)PROPAN-1-ONE;DK749;2B3CP;2-Bromo Bupropion;Bupropion Impurity 5;Bupropion Impurity 42;Bupropion impurity M1-9;Bromo Chloropropiophenone;Bupropion 2-BroMo IMpurity;Bupropion Related Compound G
CBNumber: CB3271779
Molecular Formula: C9H8BrClO
Formula Weight: 247.52
MOL File: 34911-51-8.mol

More

Less

2-Bromo-3'-chloropropiophenone Property

Boiling point:: 148-148.5 °C(Press: 9 Torr)
Density: 1.532
refractive index: 1.5770
storage temp.: Refrigerator, Under Inert Atmosphere
solubility: Soluble in acetonitrile, chloroform, dichloromethane and ethyl acetate.
form: Liquid
color: Colorless to pale yellow
InChI: InChI=1S/C9H8BrClO/c1-6(10)9(12)7-3-2-4-8(11)5-7/h2-6H,1H3
InChIKey: OFNMQTRHMBQQEA-UHFFFAOYSA-N
SMILES: C(C1=CC=CC(Cl)=C1)(=O)C(Br)C
CAS DataBase Reference: 34911-51-8(CAS DataBase Reference)

More

Less

Safety

HazardClass: IRRITANT
HS Code: 2914790000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Alfa Aesar

Product number: H64999
Product name: 2-Bromo-3'-chloropropiophenone, 98%
Packaging: 1g
Price: $29.65
Updated: 2024/03/01

Alfa Aesar

Product number: H64999
Product name: 2-Bromo-3'-chloropropiophenone, 98%
Packaging: 5g
Price: $114.65
Updated: 2024/03/01

TRC

Product number: C365035
Product name: 3’-Chloro-2-bromopropiophenone
Packaging: 1g
Price: $520
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20015
Product name: 3'-Chloro-2-bromopropiophenone
Packaging: 1g
Price: $600.6
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0045851
Product name: BUPROPION RELATED COMPOUND G
Purity: 95.00%
Packaging: 5MG
Price: $620
Updated: 2021/12/16

More

Less

2-Bromo-3'-chloropropiophenone Chemical Properties,Usage,Production

Chemical Properties

Yellow Oil

Uses

It used as an important intermediate for raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.

Definition

2-Bromo-3'-chloropropiophenone (BCP), a yellow oil, is an intermediate used in the synthesis of bupropion and is also found as an impurity of bupropion hydrochloride. Bupropion is a second-generation antidepressant that was originally approved by the United States Food and Drug Administration (FDA) in 1985. It is a norepinephrine and dopamine transporter inhibitor and an antagonist at neuronal nicotinic acetylcholine receptors. Bupropion is also approved for smoking cessation[1].

Safety

The current United States Pharmacopeia (USP) specification is for no more than 0.1% BCP in the bupropion hydrochloride monograph. The Material Safety Data Sheet from a manufacturer indicates that BCP is irritating to the eyes, respiratory system, and skin. 2-Bromo-3'-chloropropiophenone was mutagenic with S9 metabolic activation, increasing the mutant frequencies in a concentration-dependent manner, up to 22- and 145-fold induction over the controls in Salmonella strains TA100 and TA1535, respectively. BCP was also positive in the in vitro micronucleus assay, resulting in up to 3.3- and 5.1-fold increase of micronucleus frequency for treatments in the absence and presence of S9, respectively; and 9.9- and 7.4-fold increase of aneuploidies without and with S9, respectively. The addition of N-acetyl-l-cysteine, an antioxidant, reduced the genotoxicity of BCP in both assays. Further studies showed that BCP treatment resulted in induction of reactive oxygen species (ROS) in the TK6 cells. The results suggest that BCP is mutagenic, clastogenic, and aneugenic, and that these activities are mediated via generation of reactive metabolites[1].

References

[1] Meng, Fanxue , et al. "Genotoxicity of 2-bromo-3′-chloropropiophenone." Toxicology & Applied Pharmacology 270.2(2013):158-163.

2-Bromo-3'-chloropropiophenone Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-Bromo-3'-chloropropiophenone Suppliers

Canada 5 China 139 Europe 2 Germany 4 India 48 South Korea 1 Switzerland 1 Ukraine 3 United Kingdom 10 United States 25 Global 238

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9346
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 2963
Advantage: 65

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11655
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

More

Less

View Lastest Price from 2-Bromo-3'-chloropropiophenone manufacturers

Dorne Chemical Technology co. LTD

Product: 2-Bromo-3'-chloropropiophenone 34911-51-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-03-26

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 2-Bromo-3'-chloropropiophenone 34911-51-8
Price: US $100.00-75.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-14

Hubei Lidu New Material Technology Co., Ltd

Product: 2-Bromo-3'-chloropropiophenone 34911-51-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20TON
Release date: 2024-12-11

34911-51-8, 2-Bromo-3'-chloropropiophenoneRelated Search:

Propiophenone Chlorphenamine maleate BROMOACETONE Calcium pyruvate 3'-Chloropropiophenone Pyruvic acid Acetylacetone 3-Chloropropiophenone Propane 1-(3-Chlorophenyl)-1,2-propanedione Bupropion Impurity 1 2-(tert-Butylamino)-3',5'-dichloropropiophenone Hydrochloride Bupropion IMpurity ((3R,5RS,6RS)-6-(3-Chlorophenyl)-6-Hydroxy-5-Methyl-3-ThioMorpholine Carboxylic Acid) (3S,5S,6S)-Bupropion Impurity 3-Chlorobenzoic acid Bupropion Impurity 6 Bupropion Impurity 10 (3S,5R,6R)-Bupropion Impurity

2-BROMO-1-(3-CHLOROPHENYL)-1-PROPANONE

2-BROMO-1-(3-CHLOROPHENYL)PROPAN-1-ONE

2-BROMO-3'-CHLOROPROPIOPHENONE

3'-CHLORO-2-BROMOPROPIOPHENONE

3'-Chloro-α-bromopropiophenone

1-Propanone,2-broMo-1-(3-chlorophenyl)-

α-BroMo-3-chloropropiophenone

Bupropion 2-BroMo IMpurity

Bupropion Impurity 5

Bupropion impurity M1-9

2-Bromo-3'-chloropropiophenone, 2-Bromo-1-(3-chlorophenyl)-1-propanone

2-Bromo-1-(3-chlorophenyl)propan-1-

2-Bromo Bupropion

Bupropion Impurity 42

2-Bromo-3'-chloropropiophenone,98%

2-Bromo Bupropion ImpurityQ: What is 2-Bromo Bupropion Impurity Q: What is the CAS Number of 2-Bromo Bupropion Impurity Q: What is the storage condition of 2-Bromo Bupropion Impurity Q: What are the applications of 2-Bromo Bupropion Impurity

Bupropion Related Compound G

Bupropion USP Related Compound G

DK749

Bromo Chloropropiophenone

2-Bromo-3’-Chloropropiophenone (Intermediate of Bupropion )

Bupropion Related Compound G (50 mg) (2-Bromo-1-(3-chlorophenyl)propan-1-one)

2B3CP

2-Bromo-3'-chloropropiophenone

2'Bromo-3'Chloropropiophenone

34911-51-8

34911-54-8

C9H9BrClC

Aromatics