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Tioxolone

Product Name
Tioxolone
CAS No.
4991-65-5
Chemical Name
Tioxolone
Synonyms
6-HYDROXY-1,3-BENZOXATHIOL-2-ONE;Trocinate;ol110;Camyna;Stepin;Acnosan;Thiphen;tioxolon;thidoxol;ioxolone
CBNumber
CB2696092
Molecular Formula
C7H4O3S
Formula Weight
168.17
MOL File
4991-65-5.mol
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Tioxolone Property

Melting point:
158-160 °C(lit.)
Boiling point:
267.1°C (rough estimate)
Density 
1.4844 (rough estimate)
refractive index 
1.5151 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow
form 
A solid
pka
8.14±0.20(Predicted)
color 
Light yellow to yellow
Merck 
9456
LogP
1.770 (est)
CAS DataBase Reference
4991-65-5(CAS DataBase Reference)
NIST Chemistry Reference
Tioxolone(4991-65-5)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
RTECS 
DM2953750
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
217077
Product name
6-Hydroxy-1,3-benzoxathiol-2-one
Purity
≥98%
Packaging
50g
Price
$166.2
Updated
2024/03/01
Apolloscientific
Product number
OR937717
Product name
6-Hydroxy-1,3-benzoxathiol-2-one
Purity
95%
Packaging
25g
Price
$261
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
38111
Product name
6-Hydroxybenzo[d][1,3]oxathiol-2-one
Purity
95+%
Packaging
10g
Price
$350
Updated
2021/12/16
AK Scientific
Product number
V1364
Product name
Tioxolone
Packaging
25g
Price
$852
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0013052
Product name
6-HYDROXY-1,3-BENZOXATHIOL-2-ONE
Purity
95.00%
Packaging
25G
Price
$1270.5
Updated
2021/12/16
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Tioxolone Chemical Properties,Usage,Production

Chemical Properties

light yellow to beige powder

Originator

Acnosan,Unia

Uses

6-Hydroxy-1,3-benzoxathiol-2-one was used in the synthesis of heterocycle-phosphor esters having potential antimicrobial activity.

Uses

antiseborrhoic

Definition

ChEBI: A 1,3-benzoxathiole having a hydroxy substituent at the 6-position.

Manufacturing Process

40 g potassium thiocyanate in 50 ml of water are added, while stirring at room temperature, to a solution of 11 g of resorcinol and 50 g of crystallized copper sulfate in 250 ml of water. The black cupric thiocyanate formed becomes colorless after a short time, which indicates that the introduction of thiocyanogen is terminated. The cuprous thiocyanate is removed by filtering with suction and then washed with water; the filtrate is mixed with 50 ml of a 2 N sodium carbonate solution, whereby the imino-thiocarbonate of resorcinol separates in the form of a colorless crystalline body. The yield amounts to 16 g. The new compound which melts at 149°C dissolves very easily in many organic solvents and in mineral acids.
A 10% solution of the imino-thiocarbonate of resorcinol in 10% hydrochloric acid is heated for 15 min on the steam bath. The 6-hydroxy-1,3-benzoxathiol- 2-one (thiocarbonate free from) nitrogen separates, on cooling, in the form of fine crystals melting at 158°C.

Therapeutic Function

Antiseborreic, Antifungal, Keratolytic

General Description

Antimicrobial and cytostatic properties of 6-hydroxy-1,3-benzoxathiol-2-one has been investigated. Supramolecular structure of 6-hydroxy-1,3-benzoxathiol-2-one has been studied.

Tioxolone Preparation Products And Raw materials

Raw materials

Preparation Products

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Tioxolone Suppliers

Loba Feinchemie AG
Tel
--
Fax
--
Email
sales@loba.co.at
Country
Austria
ProdList
900
Advantage
61
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View Lastest Price from Tioxolone manufacturers

Career Henan Chemical Co
Product
Tioxolone 4991-65-5
Price
US $1.00/IU
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-12-27

4991-65-5, TioxoloneRelated Search:


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  • 6-HYDROXY-1,3-BENZOXATHIOL-2-ONE
  • 6-HYDROXY-1,3-BENZOXATHIOL-2-ONE, 98+%
  • 6-Hydroxy-2-oxo-1,3-benzoxathiole
  • 6-Hydroxy-2-oxobenzoxathiole
  • Acnosan
  • 6-Hydroxy-1-oxa-3-thiaindan-2-one
  • 6-Hydroxybenzo[d][1,3]oxathiol-2-one
  • THIOXOLONE
  • TIOXOLONE
  • 1,3-Benzoxathiol-2-one, 6-hydroxy-
  • 6-hydroxy-3-benzoxathiol-2-one
  • acnosan(antiseborrheic)
  • Camyna
  • component of Psoil
  • ol110
  • Stepin
  • thidoxol
  • Thioxalone
  • 6-Hydroxy-1,3-benzoxathiol-2-one&gt
  • ioxolone
  • Thixolone
  • 4991-65-5
  • C7H4O3S
  • C7H4O2S
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  • Heterocyclic Compounds
  • STEPIN