Tioxolone

ChemicalBook > CAS DataBase List > Tioxolone

Product Name: Tioxolone
CAS No.: 4991-65-5
Chemical Name: Tioxolone
Synonyms: 6-HYDROXY-1,3-BENZOXATHIOL-2-ONE;Trocinate;ol110;Camyna;Stepin;Acnosan;Thiphen;tioxolon;thidoxol;ioxolone
CBNumber: CB2696092
Molecular Formula: C7H4O3S
Formula Weight: 168.17
MOL File: 4991-65-5.mol

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Tioxolone Property

Melting point:: 158-160 °C(lit.)
Boiling point:: 267.1°C (rough estimate)
Density: 1.4844 (rough estimate)
refractive index: 1.5151 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: 95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow
form: A solid
pka: 8.14±0.20(Predicted)
color: Light yellow to yellow
Merck: 9456
LogP: 1.770 (est)
CAS DataBase Reference: 4991-65-5(CAS DataBase Reference)
NIST Chemistry Reference: Tioxolone(4991-65-5)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3
RTECS: DM2953750
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 217077
Product name: 6-Hydroxy-1,3-benzoxathiol-2-one
Purity: ≥98%
Packaging: 50g
Price: $166.2
Updated: 2024/03/01

ApexBio Technology

Product number: A4362
Product name: Tioxolone
Packaging: 1g
Price: $57
Updated: 2021/12/16

ChemScene

Product number: CS-2598
Product name: Tioxolone
Purity: 98.83%
Packaging: 1g
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR937717
Product name: 6-Hydroxy-1,3-benzoxathiol-2-one
Purity: 95%
Packaging: 5g
Price: $145
Updated: 2021/12/16

Apolloscientific

Product number: OR937717
Product name: 6-Hydroxy-1,3-benzoxathiol-2-one
Purity: 95%
Packaging: 25g
Price: $261
Updated: 2021/12/16

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Tioxolone Chemical Properties,Usage,Production

Chemical Properties

light yellow to beige powder

Originator

Acnosan,Unia

Uses

6-Hydroxy-1,3-benzoxathiol-2-one was used in the synthesis of heterocycle-phosphor esters having potential antimicrobial activity.

Uses

antiseborrhoic

Definition

ChEBI: A 1,3-benzoxathiole having a hydroxy substituent at the 6-position.

Manufacturing Process

40 g potassium thiocyanate in 50 ml of water are added, while stirring at room temperature, to a solution of 11 g of resorcinol and 50 g of crystallized copper sulfate in 250 ml of water. The black cupric thiocyanate formed becomes colorless after a short time, which indicates that the introduction of thiocyanogen is terminated. The cuprous thiocyanate is removed by filtering with suction and then washed with water; the filtrate is mixed with 50 ml of a 2 N sodium carbonate solution, whereby the imino-thiocarbonate of resorcinol separates in the form of a colorless crystalline body. The yield amounts to 16 g. The new compound which melts at 149°C dissolves very easily in many organic solvents and in mineral acids.
A 10% solution of the imino-thiocarbonate of resorcinol in 10% hydrochloric acid is heated for 15 min on the steam bath. The 6-hydroxy-1,3-benzoxathiol- 2-one (thiocarbonate free from) nitrogen separates, on cooling, in the form of fine crystals melting at 158°C.

Therapeutic Function

Antiseborreic, Antifungal, Keratolytic

General Description

Antimicrobial and cytostatic properties of 6-hydroxy-1,3-benzoxathiol-2-one has been investigated. Supramolecular structure of 6-hydroxy-1,3-benzoxathiol-2-one has been studied.

Tioxolone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tioxolone manufacturers

Career Henan Chemical Co

Product: Tioxolone 4991-65-5
Price: US $1.00/IU
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-12-27

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THIOXOLONE

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1,3-Benzoxathiol-2-one, 6-hydroxy-

6-hydroxy-3-benzoxathiol-2-one

acnosan(antiseborrheic)

Camyna

component of Psoil

ol110

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thidoxol

Thioxalone

6-Hydroxy-1,3-benzoxathiol-2-one&gt

ioxolone

Thixolone

4991-65-5

C7H4O3S

C7H4O2S

Building Blocks

Heterocyclic Building Blocks

Others

S-Containing

Heterocyclic Compounds

STEPIN