Protionamide
- Product Name
- Protionamide
- CAS No.
- 14222-60-7
- Chemical Name
- Protionamide
- Synonyms
- PROTHIONAMIDE;protion;1321th;peteha;ektebin;tuberex;RP 9778;TH-1321;9778r.p.;tebeform
- CBNumber
- CB2705774
- Molecular Formula
- C9H12N2S
- Formula Weight
- 180.27
- MOL File
- 14222-60-7.mol
Protionamide Property
- Melting point:
- 140-143°C
- Boiling point:
- 310.4±44.0 °C(Predicted)
- Density
- 1.1015 (rough estimate)
- refractive index
- 1.5300 (estimate)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 12.14±0.29(Predicted)
- color
- Yellow
- Merck
- 14,7891
- InChI
- InChI=1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)
- InChIKey
- VRDIULHPQTYCLN-UHFFFAOYSA-N
- SMILES
- C1(CCC)=NC=CC(C(N)=S)=C1
- CAS DataBase Reference
- 14222-60-7(CAS DataBase Reference)
Safety
- RTECS
- NS0650000
- HazardClass
- IRRITANT
- HS Code
- 2933399990
- Toxicity
- LD50 in mice, rats (g/kg): 1.0, 1.32 orally (Il'in)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H242Heating may cause a fire
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
H400Very toxic to aquatic life
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P220Keep/Store away from clothing/…/combustible materials.
P234Keep only in original container.
P235Keep cool.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P410Protect from sunlight.
P420Store away from other materials.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SMB00387
- Product name
- Prothionamide
- Purity
- ≥99% (HPLC)
- Packaging
- 1 g
- Price
- $87.5
- Updated
- 2025/07/31
- Product number
- SMB00387
- Product name
- Prothionamide
- Purity
- ≥99% (HPLC)
- Packaging
- 10 g
- Price
- $484
- Updated
- 2025/07/31
- Product number
- P2302
- Product name
- Prothionamide
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $42
- Updated
- 2025/07/31
- Product number
- P2302
- Product name
- Prothionamide
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $137
- Updated
- 2025/07/31
- Product number
- 16074
- Product name
- Prothionamide
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $65
- Updated
- 2024/03/01
Protionamide Chemical Properties,Usage,Production
Chemical Properties
Protionamide is Yellow Solid
Uses
Protionamide is an antibacterial used against Mycobacterium tuberculosis bacteria.
Uses
An anti-tuberculosis agent. It has also been used to treat Leprosy. Antibacterial (tuberculostatic).
Definition
ChEBI: Prothionamide is a member of pyridines.
Biological Activity
Prothionamide is the second line of drug used in leprosy and in tuberculosis. It is highly effective against Mycobacterium tuberculosis. In patients with multidrug-resistant tuberculosis (MDR-TB), prothionamide causes the development of hepatitis. In rare cases, it causes drug reaction with eosinophilia and systemic symptoms (DRESS) in patients with MDR-TB. DRESS is characterized by fever, hematologic abnormalities, skin eruption, and internal organ disruption.
Synthesis
80944-48-5
14222-60-7
GENERAL METHODS: To a reaction flask containing pyridine-4-carboxamide derivatives (1 eq.) was added tetrahydrofuran (THF, 5 mL/millimole) at room temperature and protected by argon and mixed with stirring. Subsequently, Lawesson's reagent (1.5 eq.) was added to the reaction system and the reaction was continuously stirred at room temperature for 48 to 72 hours. Upon completion of the reaction, the THF solvent was removed by distillation under reduced pressure. The residue was extracted by partitioning with saturated aqueous sodium bicarbonate (25 mL) and ethyl acetate (25 mL), and the extraction was repeated with ethyl acetate (2 x 25 mL). The organic phases were combined and dried with anhydrous magnesium sulfate (MgSO4) and subsequently concentrated under vacuum. Finally, the product was further purified by fast column chromatography (elution gradient: 0-3% methanol/dichloromethane, using a puriFlash 15-SI-HC 25G column, elution time 45 min).
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 159, p. 35 - 46
[2] Bulletin de la Societe Chimique de France, 1958, p. 687,691
Protionamide Preparation Products And Raw materials
Raw materials
Preparation Products
Protionamide Suppliers
- Tel
- 0512-62889106 13814821352;
- Fax
- 0512-62889106
- business@minshengpharm.com
- Country
- China
- ProdList
- 11
- Advantage
- 66
- Tel
- 18696113233
- 15927219311@163.com
- Country
- China
- ProdList
- 1660
- Advantage
- 58
- Tel
- 021-50182298 021-50180596
- Fax
- +86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2208
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6003
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86-21-54098501
- Fax
- +86-21-54096319
- sales@sinch.com.cn
- Country
- China
- ProdList
- 11598
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 15527768836
- 1791901229@qq.com
- Country
- China
- ProdList
- 6950
- Advantage
- 52
- Tel
- 010-82954736 13391601435
- sales@isomersyn.com
- Country
- China
- ProdList
- 3295
- Advantage
- 57
View Lastest Price from Protionamide manufacturers
- Product
- Protionamide 14222-60-7
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-08
- Product
- Protionamide 14222-60-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-16
- Product
- Prothionamide 14222-60-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10