ChemicalBook > CAS DataBase List > Protionamide

Protionamide

Product Name: Protionamide
CAS No.: 14222-60-7
Chemical Name: Protionamide
Synonyms: PROTHIONAMIDE;protion;1321th;peteha;ektebin;tuberex;RP 9778;TH-1321;9778r.p.;tebeform
CBNumber: CB2705774
Molecular Formula: C9H12N2S
Formula Weight: 180.27
MOL File: 14222-60-7.mol

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Protionamide Property

Melting point:: 140-143°C
Boiling point:: 310.4±44.0 °C(Predicted)
Density: 1.1015 (rough estimate)
refractive index: 1.5300 (estimate)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 12.14±0.29(Predicted)
color: Yellow
Merck: 14,7891
InChI: InChI=1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)
InChIKey: VRDIULHPQTYCLN-UHFFFAOYSA-N
SMILES: C1(CCC)=NC=CC(C(N)=S)=C1
CAS DataBase Reference: 14222-60-7(CAS DataBase Reference)

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Safety

RTECS: NS0650000
HazardClass: IRRITANT
HS Code: 2933399990
Toxicity: LD50 in mice, rats (g/kg): 1.0, 1.32 orally (Il'in)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H242Heating may cause a fire

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P220Keep/Store away from clothing/…/combustible materials.

P234Keep only in original container.

P235Keep cool.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P410Protect from sunlight.

P420Store away from other materials.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00387
Product name: Prothionamide
Purity: ≥99% (HPLC)
Packaging: 1 g
Price: $87.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: SMB00387
Product name: Prothionamide
Purity: ≥99% (HPLC)
Packaging: 10 g
Price: $484
Updated: 2025/07/31

TCI Chemical

Product number: P2302
Product name: Prothionamide
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: P2302
Product name: Prothionamide
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $137
Updated: 2025/07/31

Cayman Chemical

Product number: 16074
Product name: Prothionamide
Purity: ≥98%
Packaging: 1g
Price: $65
Updated: 2024/03/01

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Protionamide Chemical Properties,Usage,Production

Chemical Properties

Protionamide is Yellow Solid

Uses

Protionamide is an antibacterial used against Mycobacterium tuberculosis bacteria.

Uses

An anti-tuberculosis agent. It has also been used to treat Leprosy. Antibacterial (tuberculostatic).

Definition

ChEBI: Prothionamide is a member of pyridines.

Biological Activity

Prothionamide is the second line of drug used in leprosy and in tuberculosis. It is highly effective against Mycobacterium tuberculosis. In patients with multidrug-resistant tuberculosis (MDR-TB), prothionamide causes the development of hepatitis. In rare cases, it causes drug reaction with eosinophilia and systemic symptoms (DRESS) in patients with MDR-TB. DRESS is characterized by fever, hematologic abnormalities, skin eruption, and internal organ disruption.

Synthesis

80944-48-5

14222-60-7

GENERAL METHODS: To a reaction flask containing pyridine-4-carboxamide derivatives (1 eq.) was added tetrahydrofuran (THF, 5 mL/millimole) at room temperature and protected by argon and mixed with stirring. Subsequently, Lawesson's reagent (1.5 eq.) was added to the reaction system and the reaction was continuously stirred at room temperature for 48 to 72 hours. Upon completion of the reaction, the THF solvent was removed by distillation under reduced pressure. The residue was extracted by partitioning with saturated aqueous sodium bicarbonate (25 mL) and ethyl acetate (25 mL), and the extraction was repeated with ethyl acetate (2 x 25 mL). The organic phases were combined and dried with anhydrous magnesium sulfate (MgSO4) and subsequently concentrated under vacuum. Finally, the product was further purified by fast column chromatography (elution gradient: 0-3% methanol/dichloromethane, using a puriFlash 15-SI-HC 25G column, elution time 45 min).

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 159, p. 35 - 46
[2] Bulletin de la Societe Chimique de France, 1958, p. 687,691

Protionamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Protionamide manufacturers

airuikechemical co., ltd.

Product: Protionamide 14222-60-7
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-08

Dideu Industries Group Limited

Product: Protionamide 14222-60-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-16

Zhuozhou Wenxi import and Export Co., Ltd

Product: Prothionamide 14222-60-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

14222-60-7, ProtionamideRelated Search:

N,N-Diisopropylethylamine THIONICOTINAMIDE Cilostazol Linezolid AMoxicillin and Clavulanate PotassiuM BECLOMETHASONE Isonicotinamide Cuminaldehyde Ethionamide ISONICOTINOYL CHLORIDE HYDROCHLORIDE Chloromethyl isopropyl carbonate Diisopropylamine Isoniazid ISOPROPYLHYDRAZINE HYDROCHLORIDE Cumene THIOISONICOTINAMIDE Protionamide Protionamide hydrochloride

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Hot Sale & Hot Cake High Quality Protionamide?14222-60-7

Prothionamide (prothionamide)

ProthionamideQ: What is Prothionamide Q: What is the CAS Number of Prothionamide Q: What is the storage condition of Prothionamide

3-Propylpyridine-4-thiocarboxamide

Ethionamide Impurity C

Prothionamide, 10 mM in DMSO

14222-60-7

C9H12N2S

EKTEBIN

Amines

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds

API's

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14222-60-7