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Biperiden hydrochloride

Product Name
Biperiden hydrochloride
CAS No.
1235-82-1
Chemical Name
Biperiden hydrochloride
Synonyms
Bicamol;Tasmolin;Akiriden;NSC 84989;NSC 170950;Biperidene HCL;BIPERIDINE HCL;Biperideni Impurity;NSC 170950;NSC 84989;akinetonhydrochloride
CBNumber
CB2726050
Molecular Formula
C21H30ClNO
Formula Weight
347.92
MOL File
1235-82-1.mol
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Biperiden hydrochloride Property

Melting point:
238°
storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
form 
powder
color 
off-white
BCS Class
3/1
NIST Chemistry Reference
Akineton, hydrochloride(1235-82-1)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-R22
WGK Germany 
3
RTECS 
TN3706000
Toxicity
LD50 in rats, dogs (mg/kg): 750, 340 orally (Hanna)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B1120000
Product name
Biperiden hydrochloride
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
b1120000
Price
$220
Updated
2024/03/01
Cayman Chemical
Product number
23775
Product name
Biperiden (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$43
Updated
2023/06/20
Cayman Chemical
Product number
23775
Product name
Biperiden (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$82
Updated
2023/06/20
Cayman Chemical
Product number
23775
Product name
Biperiden (hydrochloride)
Purity
≥95%
Packaging
25mg
Price
$189
Updated
2023/06/20
Cayman Chemical
Product number
23775
Product name
Biperiden (hydrochloride)
Purity
≥95%
Packaging
50mg
Price
$334
Updated
2023/06/20
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Biperiden hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Akineton HCl,Knoll,US,1959

Uses

Antiparkinsonian;Anticholinergic

Uses

A muscarinic receptor antagonist

Uses

Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. Biperiden is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy.

Definition

ChEBI: The hydrochloride salt of biperiden. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease.

Manufacturing Process

65 grams of 3-piperidino-1-phenyl propanone-1 of the summary formula C14H29ON, produced according to Mannich's reaction by reacting acetophenone with formaldehyde and piperidine hydrochloride are dissolved in 300 cc of benzene. The resulting solution is added to an organo-magnesium solution prepared from 96 grams of [δ5-bicyclo-(2,2,1)-heptenyl-2]-chloride (also known as 5-chloro-2-norbomene) 18.5 grams of magnesium shavings, and 300 cc of ether.
The reaction mixture is boiled for half an hour under reflux. Thereafter the ether is removed by distillation, until the inside temperature reaches 65°- 70°C. The resulting benzene solution is added to 95 cc concentrated hydrochloric acid containing ice for further processing. Thereby, 3-piperidino- 1-phenyl-1-[δ5-bicyclo-(2,2,1)-heptenyl-2]-propanol-1 of the summary formula C21H29ON is obtained. The compound melts at 101°C and its chlorohydrate has a melting point of about 238°C. The compound is difficultly soluble in water, slightly soluble in ethanol, and readily soluble in methanol.

brand name

Akineton (Abbott).

Therapeutic Function

Antiparkinsonian

General Description

Biperiden hydrochloride,α-5-norbornen-2-yl- -phenyl-1-piperidinepropanolhydrochloride (Akineton hydrochloride), is a white, opticallyinactive, crystalline, odorless powder that is slightlysoluble in water, ether, alcohol, and chloroform and sparinglysoluble in methanol.

Biological Activity

Muscarinic receptor antagonist that displays some selectivity for the M 1 subtype (K i values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M 1 , M 4 , M 3 , M 2 and M 5 receptors respectively). Alleviates extrapyramidal symptoms associated with antipsychotic drugs. Displays antiparkinsonian activity.

Biochem/physiol Actions

Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. It is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy. LD50 in rats 750 mg/kg; in dogs 340 mg/kg.

Clinical Use

Biperiden hydrochloride has all of the actions describedfor biperiden. The hydrochloride is used for tablets becauseit is better suited to this dosage form than is the lactate salt.As with the free base and the lactate salt, xerostomia (drynessof the mouth) and blurred vision may occur.

Safety Profile

Poison by ingestion andintravenous routes. When heated to decomposition itemits very toxic fumes of NOx and HCl.

storage

Desiccate at +4°C

References

[1] brocks d r. anticholinergic drugs used in parkinson’s disease: an overlooked class of drugs from a pharmacokinetic perspective. j pharm pharm sci, 1999, 2(2): 39-46.
[2] espi martinez f, espi forcen f, shapov a, et al. biperiden dependence: case report and literature review. case reports in psychiatry, 2012, 2012.

Biperiden hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Biperiden hydrochloride Suppliers

Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
15229059051
Email
1027@dideu.com
Country
China
ProdList
10003
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18070
Advantage
56
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11578
Advantage
59
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View Lastest Price from Biperiden hydrochloride manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
Biperiden hydrochloride 1235-82-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1000KG
Release date
2024-11-10
Shaanxi Dideu Medichem Co. Ltd
Product
Biperiden hydrochloride 1235-82-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KG
Release date
2024-08-08
Career Henan Chemical Co
Product
Biperiden hydrochloride 1235-82-1
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2020-03-05

1235-82-1, Biperiden hydrochlorideRelated Search:


  • 1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, hydrochloride
  • NSC 170950
  • NSC 84989
  • α-(Bicyclo[2.2.1]hept-5-en-2-yl)-α-phenyl-1-piperidinepropanol hydrochloride
  • 1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol hydrochloride
  • 1-bicycloheptenyl-1-phenyl-3-piperidinopropanol-1hydrochloride
  • Akineton, Akinophyl, 1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol hydrochloride
  • 1-(Bicyclo[2.2.1]hept-5-en-2alpha-yl)-1-phenyl-3-piperidinopropanol hydrochloride
  • Akiriden
  • Bicamol
  • Tasmolin
  • Biperiden Hydrochloride (200 mg)
  • Biperidene HCL
  • α-5-Norbornen-2-yl-α-phenyl-1-piperidinepropanol Hydrochloride
  • Biperiden Hydrochloride (Mixture of Diastereomers)
  • 1-Piperidinepropanol, a-bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl-, hydrochloride (1:1)
  • Biperiden Hydrochloride\n(Mixture of Diastereomers)
  • 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol
  • 1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochloride (1:1)
  • NSC 170950;NSC 84989
  • akinetonhydrochloride
  • alpha-(bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidinepropanolhydroc
  • alpha-5-norbornen-2-yl-alpha-phenyl-1-piperidinepropanohydrochloride
  • alpha-5-norbornen-2-yl-alpha-phenyl-piperidinepropanolhydrochloride
  • biperidinehydrochloride
  • BIPERIDEN HYDROCHLORIDE
  • BIPERIDINE HCL
  • Biperidene hydrochloride
  • Piperidinepropanol, alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-, hydrochloride
  • 1-Piperidinepropanol, α-5-norbornen-2-yl-α-phenyl-, hydrochloride (6CI, 7CI, 8CI)
  • Biperiden hydrochloride CRS
  • KL 373 (Hydrochloride)
  • Biperiden hydrochloride USP/EP/BP
  • Biperiden hydrochloride salt
  • Biperiden Hydrochloride (1073004)
  • α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, hydrochloride
  • 1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, hydrochloride (1:1)
  • 1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochloride
  • Biperideni Impurity
  • 1235-82-1
  • 1234-82-1
  • C21H29NOHCl
  • Amines
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Acetylcholine receptor
  • Inhibitors
  • Akineton