Biperiden hydrochloride

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Biperiden hydrochloride

Product Name: Biperiden hydrochloride
CAS No.: 1235-82-1
Chemical Name: Biperiden hydrochloride
Synonyms: Bicamol;Tasmolin;Akiriden;NSC 84989;NSC 170950;Biperidene HCL;BIPERIDINE HCL;NSC 170950;NSC 84989;akinetonhydrochloride;KL 373 (Hydrochloride)
CBNumber: CB2726050
Molecular Formula: C21H30ClNO
Formula Weight: 347.92
MOL File: 1235-82-1.mol

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Biperiden hydrochloride Property

Melting point:: 238°
storage temp.: 2-8°C
solubility: DMSO: >20mg/mL
form: powder
color: off-white
BCS Class: 3/1
NIST Chemistry Reference: Akineton, hydrochloride(1235-82-1)

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Safety

Hazard Codes: Xn
Risk Statements: 22-R22
WGK Germany: 3
RTECS: TN3706000
Toxicity: LD50 in rats, dogs (mg/kg): 750, 340 orally (Hanna)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B1120000
Product name: Biperiden hydrochloride
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: b1120000
Price: $220
Updated: 2024/03/01

Cayman Chemical

Product number: 23775
Product name: Biperiden (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $43
Updated: 2023/06/20

Cayman Chemical

Product number: 23775
Product name: Biperiden (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $82
Updated: 2023/06/20

Cayman Chemical

Product number: 23775
Product name: Biperiden (hydrochloride)
Purity: ≥95%
Packaging: 25mg
Price: $189
Updated: 2023/06/20

Cayman Chemical

Product number: 23775
Product name: Biperiden (hydrochloride)
Purity: ≥95%
Packaging: 50mg
Price: $334
Updated: 2023/06/20

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Biperiden hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Akineton HCl,Knoll,US,1959

Uses

Antiparkinsonian;Anticholinergic

Uses

A muscarinic receptor antagonist

Uses

Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. Biperiden is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy.

Definition

ChEBI: The hydrochloride salt of biperiden. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease.

Manufacturing Process

65 grams of 3-piperidino-1-phenyl propanone-1 of the summary formula C14H29ON, produced according to Mannich's reaction by reacting acetophenone with formaldehyde and piperidine hydrochloride are dissolved in 300 cc of benzene. The resulting solution is added to an organo-magnesium solution prepared from 96 grams of [δ5-bicyclo-(2,2,1)-heptenyl-2]-chloride (also known as 5-chloro-2-norbomene) 18.5 grams of magnesium shavings, and 300 cc of ether.
The reaction mixture is boiled for half an hour under reflux. Thereafter the ether is removed by distillation, until the inside temperature reaches 65°- 70°C. The resulting benzene solution is added to 95 cc concentrated hydrochloric acid containing ice for further processing. Thereby, 3-piperidino- 1-phenyl-1-[δ5-bicyclo-(2,2,1)-heptenyl-2]-propanol-1 of the summary formula C21H29ON is obtained. The compound melts at 101°C and its chlorohydrate has a melting point of about 238°C. The compound is difficultly soluble in water, slightly soluble in ethanol, and readily soluble in methanol.

brand name

Akineton (Abbott).

Therapeutic Function

Antiparkinsonian

General Description

Biperiden hydrochloride,α-5-norbornen-2-yl- -phenyl-1-piperidinepropanolhydrochloride (Akineton hydrochloride), is a white, opticallyinactive, crystalline, odorless powder that is slightlysoluble in water, ether, alcohol, and chloroform and sparinglysoluble in methanol.

Biological Activity

Muscarinic receptor antagonist that displays some selectivity for the M 1 subtype (K i values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M 1 , M 4 , M 3 , M 2 and M 5 receptors respectively). Alleviates extrapyramidal symptoms associated with antipsychotic drugs. Displays antiparkinsonian activity.

Biochem/physiol Actions

Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. It is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy. LD50 in rats 750 mg/kg; in dogs 340 mg/kg.

Clinical Use

Biperiden hydrochloride has all of the actions describedfor biperiden. The hydrochloride is used for tablets becauseit is better suited to this dosage form than is the lactate salt.As with the free base and the lactate salt, xerostomia (drynessof the mouth) and blurred vision may occur.

Safety Profile

Poison by ingestion andintravenous routes. When heated to decomposition itemits very toxic fumes of NOx and HCl.

storage

Desiccate at +4°C

References

[1] brocks d r. anticholinergic drugs used in parkinson’s disease: an overlooked class of drugs from a pharmacokinetic perspective. j pharm pharm sci, 1999, 2(2): 39-46.
[2] espi martinez f, espi forcen f, shapov a, et al. biperiden dependence: case report and literature review. case reports in psychiatry, 2012, 2012.

Biperiden hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Biperiden hydrochloride manufacturers

Dideu Industries Group Limited

Product: Biperiden hydrochloride 1235-82-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-26

Career Henan Chemical Co

Product: Biperiden hydrochloride 1235-82-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2020-03-05

1235-82-1, Biperiden hydrochlorideRelated Search:

Haloperidol DROPERIDOL Hydroxylamine hydrochloride 1-AdaMantanethylaMine Topotecan hydrochloride Buflomedil hydrochloride Bipariden Propane 2,2,6,6-Tetramethyl-4-piperidinol PHENCYCLIDINE-D5 HYDROCHLORIDE Tramadol hydrochloride Diphenoxylate 1-Piperidinepropanol cycrimine Sibutramine hydrochloride cycrimine hydrochloride CYCLOPENTYLPHENYLMETHANOL Biperiden hydrochloride

1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, hydrochloride

NSC 170950

NSC 84989

α-(Bicyclo[2.2.1]hept-5-en-2-yl)-α-phenyl-1-piperidinepropanol hydrochloride

1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol hydrochloride

1-bicycloheptenyl-1-phenyl-3-piperidinopropanol-1hydrochloride

Akineton, Akinophyl, 1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol hydrochloride

1-(Bicyclo[2.2.1]hept-5-en-2alpha-yl)-1-phenyl-3-piperidinopropanol hydrochloride

Akiriden

Bicamol

Tasmolin

Biperiden Hydrochloride (200 mg)

Biperidene HCL

α-5-Norbornen-2-yl-α-phenyl-1-piperidinepropanol Hydrochloride

Biperiden Hydrochloride (Mixture of Diastereomers)

1-Piperidinepropanol, a-bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl-, hydrochloride (1:1)

Biperiden Hydrochloride\n(Mixture of Diastereomers)

1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol

1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochloride (1:1)

NSC 170950;NSC 84989

akinetonhydrochloride

alpha-(bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidinepropanolhydroc

alpha-5-norbornen-2-yl-alpha-phenyl-1-piperidinepropanohydrochloride

alpha-5-norbornen-2-yl-alpha-phenyl-piperidinepropanolhydrochloride

biperidinehydrochloride

BIPERIDEN HYDROCHLORIDE

BIPERIDINE HCL

Biperidene hydrochloride

Piperidinepropanol, alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-, hydrochloride

1-Piperidinepropanol, α-5-norbornen-2-yl-α-phenyl-, hydrochloride (6CI, 7CI, 8CI)

Biperiden hydrochloride CRS

KL 373 (Hydrochloride)

Biperiden hydrochloride USP/EP/BP

Biperiden hydrochloride salt

Biperiden Hydrochloride (1073004)

α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, hydrochloride

1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-, hydrochloride (1:1)

1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochloride

1235-82-1

1234-82-1

C21H29NOHCl

Amines

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Acetylcholine receptor

Inhibitors

Akineton