ODQ
- Product Name
- ODQ
- CAS No.
- 41443-28-1
- Chemical Name
- ODQ
- Synonyms
- ODQ;ODQ,98%;ODQ inhibitor;ODQ, 10 mM in DMSO;ODQ - CAS 41443-28-1 - Calbiochem;[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one;1H-[1,2,4]OXADIAZOLO[4,3-A]QUINOXALIN-1-ONE;1H-[1,2,4]OXADIAZOLE[4,3-A]QUINOXALIN-1-ONE;ODQ, NO-sensitive guanylyl cyclase inhibitor;1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one>
- CBNumber
- CB2730905
- Molecular Formula
- C9H5N3O2
- Formula Weight
- 187.15
- MOL File
- 41443-28-1.mol
ODQ Property
- Melting point:
- 160-170 °C
- Boiling point:
- 321.89°C (rough estimate)
- Density
- 1.3753 (rough estimate)
- refractive index
- 1.6500 (estimate)
- RTECS
- RO0913150
- storage temp.
- 2-8°C
- solubility
- ethanol: 1.2 mg/mL
- form
- powder
- pka
- 0.94±0.20(Predicted)
- color
- pale yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- CAS DataBase Reference
- 41443-28-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- O3636
- Product name
- 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
- Purity
- powder
- Packaging
- 5mg
- Price
- $121
- Updated
- 2025/07/31
- Product number
- 495320
- Product name
- ODQ
- Packaging
- 10mg
- Price
- $236
- Updated
- 2025/07/31
- Product number
- O0400
- Product name
- 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
- Purity
- >95.0%(GC)
- Packaging
- 25mg
- Price
- $146
- Updated
- 2025/07/31
- Product number
- 81410
- Product name
- ODQ
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 81410
- Product name
- ODQ
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $61
- Updated
- 2024/03/01
ODQ Chemical Properties,Usage,Production
Description
ODQ (41443-28-1) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC),?IC50?= 20 nM).1 ODQ acts via competition with NO for the heme site of sGC where it binds irreversibly.2?ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate GC.1?ODQ is an extremely useful tool to explore the involvement of the NO-cGMP pathway in cellular signaling and physiologic processes.3-5
Chemical Properties
ODQ is off-white to yellow powder
Uses
ODQ is a selective and potent sGC (soluble guanylyl cyclase) inhibitor.
Uses
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits neurite outgrowth and causes neurite retraction in PC12 cells independently of soluble guanylyl cyclase.
Definition
ChEBI: 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one is a member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group. It has a role as an EC 4.6.1.2 (guanylate cyclase) inhibitor.
Biological Activity
ODQ is a potent and selective inhibitor of NO-sensitive guanylyl cyclase.
Biochem/physiol Actions
H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) non competitively inhibits the action of nitric oxide-sensitive guanylyl cyclase and results in a supposedly irreversible oxidation of the prosthetic heme group. ODQ has been used to study the role of cyclic guanosine monophosphate (cGMP) pathway in nitric oxide (NO) signal transduction.
storage
+4°C
References
[1] J GARTHWAITE. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.[J]. Molecular Pharmacology, 1995, 48 2: 184-188.
[2] A SCHRAMMEL. Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase.[J]. Molecular Pharmacology, 1996, 50 1: 1-5.
[3] A G ESTÉVEZ. Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor.[J]. Journal of Neuroscience, 1998, 18 10: 3708-3714.
[4] G VANDECASTEELE R F T Eschenhagen. Role of the NO-cGMP pathway in the muscarinic regulation of the L-type Ca2+ current in human atrial myocytes.[J]. Journal of Physiology-London, 1998, 506 ( Pt 3): 653-663. DOI:10.1111/j.1469-7793.1998.653bv.x
[5] M C MARTINS-PINGE O U L G C Araújo. Nitric oxide-dependent guanylyl cyclase participates in the glutamatergic neurotransmission within the rostral ventrolateral medulla of awake rats.[J]. Hypertension, 1999, 34 4 Pt 2: 748-751. DOI:10.1161/01.hyp.34.4.748
ODQ Preparation Products And Raw materials
Raw materials
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