ODQ
- Product Name
- ODQ
- CAS No.
- 41443-28-1
- Chemical Name
- ODQ
- Synonyms
- ODQ;ODQ,98%;ODQ inhibitor;ODQ, 10 mM in DMSO;ODQ - CAS 41443-28-1 - Calbiochem;[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one;1H-[1,2,4]OXADIAZOLO[4,3-A]QUINOXALIN-1-ONE;1H-[1,2,4]OXADIAZOLE[4,3-A]QUINOXALIN-1-ONE;ODQ, NO-sensitive guanylyl cyclase inhibitor;1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one>
- CBNumber
- CB2730905
- Molecular Formula
- C9H5N3O2
- Formula Weight
- 187.15
- MOL File
- 41443-28-1.mol
ODQ Property
- Melting point:
- 160-170 °C
- Boiling point:
- 321.89°C (rough estimate)
- Density
- 1.3753 (rough estimate)
- refractive index
- 1.6500 (estimate)
- RTECS
- RO0913150
- storage temp.
- 2-8°C
- solubility
- ethanol: 1.2 mg/mL
- form
- powder
- pka
- 0.94±0.20(Predicted)
- color
- pale yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- CAS DataBase Reference
- 41443-28-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- O3636
- Product name
- 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
- Purity
- powder
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- 495320
- Product name
- ODQ
- Packaging
- 10mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- O0400
- Product name
- 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
- Purity
- >95.0%(GC)
- Packaging
- 25mg
- Price
- $162
- Updated
- 2024/03/01
- Product number
- J62250
- Product name
- 1H-[1,2,4]Oxadiazolo[4,3-a]-quinoxalin-1-one, 98+%
- Packaging
- 10mg
- Price
- $96.65
- Updated
- 2024/03/01
- Product number
- J62250
- Product name
- 1H-[1,2,4]Oxadiazolo[4,3-a]-quinoxalin-1-one, 98+%
- Packaging
- 50mg
- Price
- $323.65
- Updated
- 2024/03/01
ODQ Chemical Properties,Usage,Production
Description
ODQ (41443-28-1) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC),?IC50?= 20 nM).1 ODQ acts via competition with NO for the heme site of sGC where it binds irreversibly.2?ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate GC.1?ODQ is an extremely useful tool to explore the involvement of the NO-cGMP pathway in cellular signaling and physiologic processes.3-5
Chemical Properties
ODQ is off-white to yellow powder
Uses
ODQ is a selective and potent sGC (soluble guanylyl cyclase) inhibitor.
Uses
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits neurite outgrowth and causes neurite retraction in PC12 cells independently of soluble guanylyl cyclase.
Definition
ChEBI: 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one is a member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group. It has a role as an EC 4.6.1.2 (guanylate cyclase) inhibitor.
Biological Activity
ODQ is a potent and selective inhibitor of NO-sensitive guanylyl cyclase.
Biochem/physiol Actions
H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) non competitively inhibits the action of nitric oxide-sensitive guanylyl cyclase and results in a supposedly irreversible oxidation of the prosthetic heme group. ODQ has been used to study the role of cyclic guanosine monophosphate (cGMP) pathway in nitric oxide (NO) signal transduction.
storage
+4°C
References
1) Garthwaite?et al.?(1995),?Potent and Selective Inhibition of Nitric Oxide-sensitive Guanylyl Cyclase by 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one; Mol. Pharmacol.?48?184 2) Schrammel?et al.?(1996),?Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase; Mol. Pharmacol.?50?1 3) Estevez?et al.?(1998),?Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor; J. Neurosci.?18?3708 4) Vandecasteele?et al.?(1998),?Role of the NO-cGMP in the muscarinic regulation of the L-type Ca2+ current in human atrial myocytes; J. Physiol.?506?653 5) Martins-Pinge?et al.?(1999),?Nitric oxide-dependent guanylyl cyclase participates in the glutamatergic neurotransmission within the rostral ventrolateral medulla of awake rats;?Hypertension?34?748
ODQ Preparation Products And Raw materials
Raw materials
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