3-AMINOPYRAZINE-2-CARBONITRILE
- Product Name
- 3-AMINOPYRAZINE-2-CARBONITRILE
- CAS No.
- 25911-65-3
- Chemical Name
- 3-AMINOPYRAZINE-2-CARBONITRILE
- Synonyms
- BUTTPARK 29\04-92;2-aMino-3-cyanopyrazine;3-Amino-2-pyrazinecarbonitrile;Pyrazinecarbonitrile, 3-amino-;3-AMINOPYRAZINE-2-CARBONITRILE;2-Pyrazinecarbonitrile, 3-amino-;3-AMINOPYRAZINE-2-CARBONITRILE ISO 9001：2015 REACH
- CBNumber
- CB2737212
- Molecular Formula
- C5H4N4
- Formula Weight
- 120.11
- MOL File
- 25911-65-3.mol
3-AMINOPYRAZINE-2-CARBONITRILE Property
- Melting point:
- 191.9 °C
- Boiling point:
- 364.8±42.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.45±0.10(Predicted)
- Appearance
- Light brown to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A629173
- Product name
- 3-Aminopyrazine-2-carbonitrile
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A629173
- Product name
- 3-Aminopyrazine-2-carbonitrile
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-D1579
- Product name
- 3-Aminopyrazine-2-carbonitrile
- Purity
- >98.0%
- Packaging
- 1g
- Price
- $56
- Updated
- 2021/12/16
- Product number
- FA142761
- Product name
- 3-Aminopyrazine-2-carbonitrile
- Packaging
- 500mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- CS-D1579
- Product name
- 3-Aminopyrazine-2-carbonitrile
- Purity
- >98.0%
- Packaging
- 5g
- Price
- $121
- Updated
- 2021/12/16
3-AMINOPYRAZINE-2-CARBONITRILE Chemical Properties,Usage,Production
Uses
3-Aminopyrazine-2-carbonitrile is a useful synthesis reagent.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 26, p. 817, 1989 DOI: 10.1002/jhet.5570260357
Synthesis
32587-10-3
25911-65-3
Example 3 Synthesis of 3-aminopyrazine-2-carbonitrile (Intermediate 2): Intermediate 1 (3-aminopyrazine-2-carboxamide, 3.5 g, 25 mmol) was dissolved in DMF (40 mL) at room temperature, followed by slow dropwise addition of POCl3 (4.5 mL, 49 mmol). The reaction mixture was heated at 80 °C with stirring for 15 min, after which it was cooled to room temperature. The reaction mixture was slowly poured into ice water and the pH was adjusted to neutral with 10% NaOH solution. The precipitated solid was collected by filtration and redissolved in 5% HCl solution. The acidic solution was heated at 70 °C for 30 min, followed by filtration to separate the solid product. The target compound 3-aminopyrazine-2-carbonitrile was obtained as a brown solid (1.7 g, 56% yield) after sufficient washing with water. The product was characterized by 1H NMR (500 MHz, DMSO-d6): δ 8.28 (d, J=2.4 Hz, 1H), 7.90 (d, J=2.4 Hz, 1H), 7.32 (br s, 2H). Mass spectrum (ES+): m/z 121 ([M+H]+).
References
[1] Patent: US2007/259876, 2007, A1. Location in patent: Page/Page column 18
[2] Journal of the American Chemical Society, 1945, vol. 67, p. 1711
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 12, p. 3238 - 3242
3-AMINOPYRAZINE-2-CARBONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-AMINOPYRAZINE-2-CARBONITRILE manufacturers
- Product
- 3-AMinopyrazine-2-carbonitrile 25911-65-3
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-29
- Product
- 3-AMINOPYRAZINE-2-CARBONITRILE 25911-65-3
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 98% HPLC
- Supply Ability
- 10t
- Release date
- 2019-12-20
- Product
- 3-AMINOPYRAZINE-2-CARBONITRILE 25911-65-3
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 98% HPLC
- Supply Ability
- 10t
- Release date
- 2019-12-20