ChemicalBook > CAS DataBase List > 3-AMINOPYRAZINE-2-CARBONITRILE

3-AMINOPYRAZINE-2-CARBONITRILE

Product Name
3-AMINOPYRAZINE-2-CARBONITRILE
CAS No.
25911-65-3
Chemical Name
3-AMINOPYRAZINE-2-CARBONITRILE
Synonyms
BUTTPARK 29\04-92;2-aMino-3-cyanopyrazine;3-Amino-2-pyrazinecarbonitrile;Pyrazinecarbonitrile, 3-amino-;3-AMINOPYRAZINE-2-CARBONITRILE;2-Pyrazinecarbonitrile, 3-amino-;3-AMINOPYRAZINE-2-CARBONITRILE ISO 9001：2015 REACH
CBNumber
CB2737212
Molecular Formula
C5H4N4
Formula Weight
120.11
MOL File
25911-65-3.mol
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3-AMINOPYRAZINE-2-CARBONITRILE Property

Melting point:
191.9 °C
Boiling point:
364.8±42.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
1.45±0.10(Predicted)
Appearance
Light brown to yellow Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A629173
Product name
3-Aminopyrazine-2-carbonitrile
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
A629173
Product name
3-Aminopyrazine-2-carbonitrile
Packaging
100mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA142761
Product name
3-Aminopyrazine-2-carbonitrile
Packaging
2g
Price
$263
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA142761
Product name
3-Aminopyrazine-2-carbonitrile
Packaging
1g
Price
$151
Updated
2021/12/16
ChemScene
Product number
CS-D1579
Product name
3-Aminopyrazine-2-carbonitrile
Purity
>98.0%
Packaging
1g
Price
$56
Updated
2021/12/16
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3-AMINOPYRAZINE-2-CARBONITRILE Chemical Properties,Usage,Production

Uses

3-Aminopyrazine-2-carbonitrile is a useful synthesis reagent.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 26, p. 817, 1989 DOI: 10.1002/jhet.5570260357

Synthesis

32587-10-3

25911-65-3

Example 3 Synthesis of 3-aminopyrazine-2-carbonitrile (Intermediate 2): Intermediate 1 (3-aminopyrazine-2-carboxamide, 3.5 g, 25 mmol) was dissolved in DMF (40 mL) at room temperature, followed by slow dropwise addition of POCl3 (4.5 mL, 49 mmol). The reaction mixture was heated at 80 °C with stirring for 15 min, after which it was cooled to room temperature. The reaction mixture was slowly poured into ice water and the pH was adjusted to neutral with 10% NaOH solution. The precipitated solid was collected by filtration and redissolved in 5% HCl solution. The acidic solution was heated at 70 °C for 30 min, followed by filtration to separate the solid product. The target compound 3-aminopyrazine-2-carbonitrile was obtained as a brown solid (1.7 g, 56% yield) after sufficient washing with water. The product was characterized by 1H NMR (500 MHz, DMSO-d6): δ 8.28 (d, J=2.4 Hz, 1H), 7.90 (d, J=2.4 Hz, 1H), 7.32 (br s, 2H). Mass spectrum (ES+): m/z 121 ([M+H]+).

References

[1] Patent: US2007/259876, 2007, A1. Location in patent: Page/Page column 18
[2] Journal of the American Chemical Society, 1945, vol. 67, p. 1711
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 12, p. 3238 - 3242

3-AMINOPYRAZINE-2-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-AMINOPYRAZINE-2-CARBONITRILE Suppliers

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View Lastest Price from 3-AMINOPYRAZINE-2-CARBONITRILE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3-AMinopyrazine-2-carbonitrile 25911-65-3
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
800 tons
Release date
2020-04-29
Career Henan Chemical Co
Product
3-AMINOPYRAZINE-2-CARBONITRILE 25911-65-3
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
98% HPLC
Supply Ability
10t
Release date
2019-12-20
Career Henan Chemical Co
Product
3-AMINOPYRAZINE-2-CARBONITRILE 25911-65-3
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
98% HPLC
Supply Ability
10t
Release date
2019-12-20

25911-65-3, 3-AMINOPYRAZINE-2-CARBONITRILERelated Search:

3-AMINOPYRAZINE-2-CARBONITRILE 5-AMINOPYRAZINE-2-CARBONITRILE Aminopyrazine 3-(4-ALLYLPIPERAZIN-1-YL)-2-QUINOXALINECARBONITRILE MALEATE 3-AMINO-6-(CHLOROMETHYL)-2-PYRAZINECARBONITRILE 4-OXIDE 3-AMINO-2-QUINOXALINECARBONITRILE 1,4-DIOXIDE 2-AMINO-3-CYANO-5-METHYLPYRAZINE 1-OXIDE 3-AMINO-2-QUINOXALINECARBONITRILE 3-(4-ALLYLPIPERAZIN-1-YL)-2-QUINOXALINECARBONITRILE 2-Amino-3-cyano-5-phenylpyrazine 3-PIPERAZIN-1YLPYRAZINE-2-CARBONITRILE 5-ACETOXYMETHYL-2-AMINO-3-CYANOPYRAZINE 2-AMINO-3-CYANO-5-([(2,4-DICHLORO-5-METHYLPHENYL)THIO]METHYL)PYRAZIN-1-IUM-1-OLATE 3-CYANO-5-PHENYL-2-PYRAZINYLFORMAMIDE 2-AMINO-3-CYANO-5-PHENYLPYRAZIN-1-IUM-1-OLATE AURORA KA-6204 AKOS BB-7539 3-(4-BENZHYDRYLPIPERAZINO)PYRAZINE-2-CARBONITRILE

  • BUTTPARK 29\04-92
  • 3-AMINOPYRAZINE-2-CARBONITRILE
  • 2-aMino-3-cyanopyrazine
  • Pyrazinecarbonitrile, 3-amino-
  • 3-Amino-2-pyrazinecarbonitrile
  • 2-Pyrazinecarbonitrile, 3-amino-
  • 3-AMINOPYRAZINE-2-CARBONITRILE ISO 9001：2015 REACH
  • 25911-65-3
  • Pyrazine