5-Fluoro-1-tetralone
- Product Name
- 5-Fluoro-1-tetralone
- CAS No.
- 93742-85-9
- Chemical Name
- 5-Fluoro-1-tetralone
- Synonyms
- 5-fluoro-3,4-dihydronaphthalen-1(2H)-one;5-Fluro-1-tetralone;5-FLUORO-A-TETRALONE;5-FLUORO-1-TETRALONE;5-Fluoro-α-Tetralone;5-Fluoro-3,4-dihydro-2H-phthalen-1-one;5-FLUORO-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE;1(2H)-Naphthalenone, 5-fluoro-3,4-dihydro-;5-Fluoro-1,2,3,4-tetrahydronaphthalen-1-one;2(1H)-Naphthalenone,5-fluoro-3,4-dihydro-(9CI)
- CBNumber
- CB2749709
- Molecular Formula
- C10H9FO
- Formula Weight
- 164.18
- MOL File
- 93742-85-9.mol
5-Fluoro-1-tetralone Property
- storage temp.
- 2-8°C
- Appearance
- White to yellow Solid
Safety
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PC904824
- Product name
- 5-Fluoro-3,4-dihydronaphthalen-1(2H)-one
- Purity
- 97%
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- PC904824
- Product name
- 5-Fluoro-3,4-dihydronaphthalen-1(2H)-one
- Purity
- 97%
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- PC904824
- Product name
- 5-Fluoro-3,4-dihydronaphthalen-1(2H)-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $352
- Updated
- 2021/12/16
- Product number
- 2717-3-18
- Product name
- 5-Fluoro-1,2,3,4-tetrahydronaphthalen-1-one
- Purity
- 97%
- Packaging
- 250mg
- Price
- $395
- Updated
- 2021/12/16
- Product number
- HCH0037604
- Product name
- 5-FLUORO-ALPHA-TETRALONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
5-Fluoro-1-tetralone Chemical Properties,Usage,Production
Synthesis
143654-62-0
93742-85-9
The general procedure for the synthesis of 5-fluoro-3,4-dihydronaphthalen-1(2H)-one from 4-(2-fluorophenyl)butyric acid was as follows: 0.15 g of 4-(2-fluorophenyl)butyric acid was added to a round-bottomed flask, which was dissolved in 20 mL of dichloromethane (DCM) and the solution was cooled to 0 °C. Subsequently, 0.15 mL of oxalyl chloride was slowly added and 1 drop of N,N-dimethylformamide (DMF) was added as a catalyst. A drying tube was installed and the reaction mixture was kept stirred at 0 °C for 2 hours. Upon completion of the reaction, 0.121 g of anhydrous aluminum chloride was added and the reaction mixture was slowly warmed to room temperature and stirring was continued overnight. The reaction mixture was carefully poured into ice water and extracted three times with dichloromethane. The organic layers were combined and washed sequentially with 0.5 M sodium hydroxide solution and saturated brine. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure, and the resulting crude product was purified by column chromatography (eluent: 20% ethyl acetate/hexane) to afford 0.07 g (53% yield) of the target compound 5-fluoro-3,4-dihydronaphthalen-1(2H)-one (32). In addition, 5-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine (34) was synthesized.
References
[1] Angewandte Chemie - International Edition, 2013, vol. 52, # 35, p. 9266 - 9270
[2] Angew. Chem., 2013, vol. 125, # 35, p. 9436 - 9440
[3] Chemistry - A European Journal, 2015, vol. 21, # 14, p. 5561 - 5583
[4] Patent: US2008/119496, 2008, A1. Location in patent: Page/Page column 12
[5] Patent: EP2128154, 2009, A1. Location in patent: Page/Page column 33
5-Fluoro-1-tetralone Preparation Products And Raw materials
Raw materials
Preparation Products
5-Fluoro-1-tetralone Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 5-Fluoro-1-tetralone manufacturers
- Product
- 5-Fluoro-1-tetralone 93742-85-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 20kgs/month
- Release date
- 2021-11-14
- Product
- 5-Fluoro-1-tetralone 93742-85-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-12-18