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Salmeterol xinafoate

Product Name
Salmeterol xinafoate
CAS No.
94749-08-3
Chemical Name
Salmeterol xinafoate
Synonyms
1-Hydroxy-2-naphthoate;Serevent;Salmeterol hydroxynaphthoate;Salmeterol Xinafoate (1609603);Arial;SN 408;Siduomi;GR 3343G;GR-33343G;Salmetedur
CBNumber
CB2751968
Molecular Formula
C36H45NO7
Formula Weight
603.74
MOL File
94749-08-3.mol
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Salmeterol xinafoate Property

Melting point:
137-138°C
storage temp. 
2-8°C
solubility 
H2O: slightly soluble
form 
solid
color 
white
Merck 
14,8337
InChIKey
XTZNCVSCVHTPAI-UHFFFAOYSA-N
CAS DataBase Reference
94749-08-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
RTECS 
QJ1970500
HS Code 
2922504500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S5068
Product name
Salmeterol xinafoate
Purity
≥98% (HPLC), solid
Packaging
10mg
Price
$225
Updated
2024/03/01
Sigma-Aldrich
Product number
1609603
Product name
Salmeterol xinafoate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
150mg
Price
$1070
Updated
2024/03/01
TCI Chemical
Product number
A3190
Product name
Salmeterol Xinafoate
Purity
>98.0%(HPLC)(T)
Packaging
250mg
Price
$69
Updated
2024/03/01
TCI Chemical
Product number
A3190
Product name
Salmeterol Xinafoate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$188
Updated
2024/03/01
Cayman Chemical
Product number
16009
Product name
Salmeterol xinafoate
Purity
≥98%
Packaging
10mg
Price
$110
Updated
2024/03/01
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Salmeterol xinafoate Chemical Properties,Usage,Production

Description

Salmeterol hydroxynaphthoate is a new long-acting β2-selective adrenoceptor agonist introduced as a bronchodilator for the treatment of reversible airway obstruction in asthma and chronic bronchitis. It has bronchodilatory activity as intense and four times longerlasting than equivalent doses of salbutamol. Salmeterol hydroxynaphthoate is reported to be the first bronchodilator with significant anti-inflammatory activity and hence could complement prophylactic corticosteroid therapy.

Description

Salmeterol is a long-acting β2-adrenergic receptor agonist (β2-AR; EC50s = 0.79, 63.1, and 9.4 nM for β2-, β1-, and β3-ARs, respectively). It inhibits electrically-stimulated contraction of isolated guinea pig trachea strips (EC50 = 2.51 nM) and histamine-induced bronchoconstriction in guinea pigs via aerosol administration of doses ranging from 0.12 to 12 mM. Salmeterol binds to an exosite domain of β2-adrenergic receptors, producing a slow onset of action and prolonged activation. Formulations containing salmeterol have been used in the treatment of asthma, including exercise-induced asthma, and chronic obstructive pulmonary disease.

Chemical Properties

White to Off-White Solid

Originator

Glaxo (United Kingdom)

Uses

A ?-Adrenergic agonist. Structural analog of albuterol

Uses

A β2-Adrenergic agonist. Structural analog of Albuterol (A514500).

Uses

Smooth wheezing anti-inflammatory

Uses

Bronchodilator; Beta2-adrenoceptor agonist

Application

Salmeterol xinafoate is a potent and selective β2-adrenoceptor agonist (EC50 = 5.3 nM) that displays bronchodilator actions. Unlike other β2- adrenoceptor agonists, Salmeterol binds to exo-site domain of β2-AR receptors, producing a slow onset of action and prolonged activation. Clinically used for the treatment of asthma and chronic obstructive pulmonary disease(COPD).

Definition

ChEBI: Salmeterol xinafoate is a naphthoic acid.

brand name

Serevent (GlaxoSmithKline).

Biochem/physiol Actions

β2-adrenoceptor agonist.

storage

Desiccate at RT

Salmeterol xinafoate Preparation Products And Raw materials

Raw materials

Preparation Products

Atracurium besylate
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Salmeterol xinafoate Suppliers

Americas 1 Canada 3 China 275 Europe 3 Finland 2 France 3 Germany 5 Greece 1 India 78 Italy 2 Japan 1 Mexico 1 Nepal 1 Poland 1 South Korea 1 Spain 2 Switzerland 4 United Arab Emirates 1 United Kingdom 19 United States 34 Global 438
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
Chemtex Pharma Inc.
Tel
--
Fax
--
Email
contact@chemtexpharma.com
Country
Canada
ProdList
163
Advantage
58
McTony Bio&Chem Inc.
Tel
--
Fax
--
Email
sales@mctony.com
Country
Canada
ProdList
242
Advantage
39
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View Lastest Price from Salmeterol xinafoate manufacturers

Wuhan Senwayer Century Chemical Co.,Ltd
Product
Salmeterol xinafoate 94749-08-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 TONS
Release date
2022-11-07
Zibo Hangyu Biotechnology Development Co., Ltd
Product
Salmeterol xinafoate 94749-08-3
Price
US $55.00-550.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-20
Zhuozhou Wenxi import and Export Co., Ltd
Product
Salmeterol xinafoate 94749-08-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

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  • (+/-) 4-HYDROXY-A1-[[[6-(4-PHENYLBUTOXY)HEXYL]AMINO]M-ETHYL]-1,3-BENZENEDIMETHANOL XINAFOATE
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  • 2-Naphthalenecarboxylic acid, 1-hydroxy-, compd. with 4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (1:1) (9CI)
  • GR 3343G
  • Serevent Diskus
  • Siduomi
  • SN 408
  • SALMETEROL XINAFOATE
  • SALMETEROL XINAFONATE
  • 4-(1-Hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenol 1-hydroxy-2-naph
  • 1-Hydroxy-2-naphthoate
  • 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthalenecarboxylic acid salt
  • Salmeterol xinafoate CRS
  • GR 33343X xinafoate, (±) 4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]m-ethyl]-1,3-benzenedimethanol xinafoate
  • 2-(Hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol 1-hydroxy-2-naphthoate
  • (±)-4-Hydroxy-alpha1-[[[6-(4-phenylbutoxy)hexy])amino]methyl]-1,3-benzenedimethanol xinafoate
  • Salmeterol Xinafoate 2-(Hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol 1-hydroxy-2-naphthoate
  • Salmeterol hydroxynaphthoate
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  • salMaterol xinafoate
  • 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]aMino]Methyl]-1,3-benzenediMethanol 1-Hydroxy-2-naphthalenecarboxylic Acid
  • SalMeterol-d12 Xinafoate salt
  • 4-(1-Hydroxy-2-((6-(4-phenylbutoxy)hexyl)aMino)ethyl)-2-(hydroxyMethyl)phenol 1-hydroxy-2-naphthoate
  • AtracuriuM Besilate IMp. J (EP)
  • 4-(1-Hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenol 1-hydroxy-2-naphtho
  • SalMeterol Solution
  • 4-Hydroxy-alpha-({[6-(4-phenylbutoxy)hexyl]amino}methyl)-1,3-benzenedimethanol xinafoate, GR 33343X xinafoate
  • SalMeterol Hydroxynapthoate
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  • Salmeterol xinafoate for peak identification CRS
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  • Salmeterol Xinafoate (GR 33343X xinafoate)
  • Salmeterol D12 Xinafoate saltQ: What is Salmeterol D12 Xinafoate salt Q: What is the CAS Number of Salmeterol D12 Xinafoate salt Q: What is the storage condition of Salmeterol D12 Xinafoate salt Q: What are the applications of Salmeterol D12 Xinafoate salt
  • Salmeterol Xinafoate-d3
  • Salmeterol XinafoateQ: What is Salmeterol Xinafoate Q: What is the CAS Number of Salmeterol Xinafoate Q: What is the storage condition of Salmeterol Xinafoate Q: What are the applications of Salmeterol Xinafoate
  • Salmeterol Xinafoate (1609603)
  • Salmeterol sinaphthate
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  • C16904920 SalmeteroLxinafoate
  • Salmeterol xinafoate, beta2 adrenoceptor agonist
  • 94749-08-3
  • 29213-08-3
  • C36H45NO7
  • C25H37NO4C11H8O3