Salmeterol xinafoate

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Salmeterol xinafoate

Product Name: Salmeterol xinafoate
CAS No.: 94749-08-3
Chemical Name: Salmeterol xinafoate
Synonyms: 1-Hydroxy-2-naphthoate;Serevent;Salmeterol hydroxynaphthoate;Salmeterol Xinafoate (1609603);Arial;SN 408;Siduomi;GR 3343G;GR-33343G;Salmetedur
CBNumber: CB2751968
Molecular Formula: C36H45NO7
Formula Weight: 603.74
MOL File: 94749-08-3.mol

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Salmeterol xinafoate Property

Melting point:: 137-138°C
storage temp.: 2-8°C
solubility: H₂O: slightly soluble
form: solid
color: white
Merck: 14,8337
InChIKey: XTZNCVSCVHTPAI-UHFFFAOYSA-N
CAS DataBase Reference: 94749-08-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-36-26
WGK Germany: 3
RTECS: QJ1970500
HS Code: 2922504500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S5068
Product name: Salmeterol xinafoate
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $225
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1609603
Product name: Salmeterol xinafoate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 150mg
Price: $1070
Updated: 2024/03/01

TCI Chemical

Product number: A3190
Product name: Salmeterol Xinafoate
Purity: >98.0%(HPLC)(T)
Packaging: 250mg
Price: $69
Updated: 2024/03/01

TCI Chemical

Product number: A3190
Product name: Salmeterol Xinafoate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $188
Updated: 2024/03/01

Cayman Chemical

Product number: 16009
Product name: Salmeterol xinafoate
Purity: ≥98%
Packaging: 10mg
Price: $110
Updated: 2024/03/01

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Salmeterol xinafoate Chemical Properties,Usage,Production

Description

Salmeterol hydroxynaphthoate is a new long-acting β2-selective adrenoceptor agonist introduced as a bronchodilator for the treatment of reversible airway obstruction in asthma and chronic bronchitis. It has bronchodilatory activity as intense and four times longerlasting than equivalent doses of salbutamol. Salmeterol hydroxynaphthoate is reported to be the first bronchodilator with significant anti-inflammatory activity and hence could complement prophylactic corticosteroid therapy.

Description

Salmeterol is a long-acting β₂-adrenergic receptor agonist (β₂-AR; EC₅₀s = 0.79, 63.1, and 9.4 nM for β₂-, β₁-, and β₃-ARs, respectively). It inhibits electrically-stimulated contraction of isolated guinea pig trachea strips (EC₅₀ = 2.51 nM) and histamine-induced bronchoconstriction in guinea pigs via aerosol administration of doses ranging from 0.12 to 12 mM. Salmeterol binds to an exosite domain of β₂-adrenergic receptors, producing a slow onset of action and prolonged activation. Formulations containing salmeterol have been used in the treatment of asthma, including exercise-induced asthma, and chronic obstructive pulmonary disease.

Chemical Properties

White to Off-White Solid

Originator

Glaxo (United Kingdom)

Uses

A ?-Adrenergic agonist. Structural analog of albuterol

Uses

A β2-Adrenergic agonist. Structural analog of Albuterol (A514500).

Uses

Smooth wheezing anti-inflammatory

Uses

Bronchodilator; Beta2-adrenoceptor agonist

Application

Salmeterol xinafoate is a potent and selective β2-adrenoceptor agonist (EC50 = 5.3 nM) that displays bronchodilator actions. Unlike other β2- adrenoceptor agonists, Salmeterol binds to exo-site domain of β2-AR receptors, producing a slow onset of action and prolonged activation. Clinically used for the treatment of asthma and chronic obstructive pulmonary disease(COPD).

Definition

ChEBI: Salmeterol xinafoate is a naphthoic acid.

brand name

Serevent (GlaxoSmithKline).

Biochem/physiol Actions

β2-adrenoceptor agonist.

storage

Desiccate at RT

Salmeterol xinafoate Preparation Products And Raw materials

Raw materials

Preparation Products

Atracurium besylate

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View Lastest Price from Salmeterol xinafoate manufacturers

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Salmeterol xinafoate 94749-08-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 TONS
Release date: 2022-11-07

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Salmeterol xinafoate 94749-08-3
Price: US $55.00-550.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-20

Zhuozhou Wenxi import and Export Co., Ltd

Product: Salmeterol xinafoate 94749-08-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

94749-08-3, Salmeterol xinafoateRelated Search:

2-Phenylphenol 4-Aminophenol Nonylphenol Meloxicam Tamoxifen citrate Salmeterol Tris(hydroxymethyl)nitromethane p-(2-Methoxyethyl) phenol Phenol Red Phenol 2-Naphthoic acid 4-Phenylphenol CHLOROPHOSPHONAZO III 1-Hydroxyethylidene-1,1-diphosphonic acid Hydroquinone 1-Hydroxy-2-naphthoic acid Benzoic acid, 3-acetyl-4-(phenylmethoxy)-, methyl ester Salbutamol Acetonide

(+/-) 4-HYDROXY-A1-[[[6-(4-PHENYLBUTOXY)HEXYL]AMINO]M-ETHYL]-1,3-BENZENEDIMETHANOL XINAFOATE

GR 33343X XINAFOATE

Arial

GR-33343G

Salmetedur

Salmeterol, 1-Hydroxy-2-naphthoate

Serevent

1,3-Benzenedimethanol, 4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-, (+-)-, 1-hydroxy-2-naphthalenecarboxylate (salt)

1,3-Benzenedimethanol, 4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-, 1-hydroxy-2-naphthalenecarboxylate (salt) (9CI)

2-Naphthalenecarboxylic acid, 1-hydroxy-, compd. with (+-)-4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (1:1)

2-Naphthalenecarboxylic acid, 1-hydroxy-, compd. with 4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (1:1) (9CI)

GR 3343G

Serevent Diskus

Siduomi

SN 408

SALMETEROL XINAFOATE

SALMETEROL XINAFONATE

4-(1-Hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenol 1-hydroxy-2-naph

1-Hydroxy-2-naphthoate

4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthalenecarboxylic acid salt

Salmeterol xinafoate CRS

GR 33343X xinafoate, (±) 4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]m-ethyl]-1,3-benzenedimethanol xinafoate

2-(Hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol 1-hydroxy-2-naphthoate

(±)-4-Hydroxy-alpha1-[[[6-(4-phenylbutoxy)hexy])amino]methyl]-1,3-benzenedimethanol xinafoate

Salmeterol Xinafoate 2-(Hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol 1-hydroxy-2-naphthoate

Salmeterol hydroxynaphthoate

Salmeterol Xinafoate (150 mg)

SalMeterol Xinafoate Aerosol

salMaterol xinafoate

4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]aMino]Methyl]-1,3-benzenediMethanol 1-Hydroxy-2-naphthalenecarboxylic Acid

SalMeterol-d12 Xinafoate salt

4-(1-Hydroxy-2-((6-(4-phenylbutoxy)hexyl)aMino)ethyl)-2-(hydroxyMethyl)phenol 1-hydroxy-2-naphthoate

AtracuriuM Besilate IMp. J (EP)

4-(1-Hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenol 1-hydroxy-2-naphtho

SalMeterol Solution

4-Hydroxy-alpha-({[6-(4-phenylbutoxy)hexyl]amino}methyl)-1,3-benzenedimethanol xinafoate, GR 33343X xinafoate

SalMeterol Hydroxynapthoate

JigMei acid salMeterol

4-hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol with 1-hydroxy-2-naphthalenecarboxylic acid(1:1)

Salmaterol Xinafloate

4-(1-hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenol 8-hydroxy-1-naphthoate

Salmeterol xinafoate for system suitability CRS

Salmeterol xinafoate for peak identification CRS

Salmeterol in Methanol

Salmeterol xinafoate USP/EP/BP

Salmeterol Xinafoate (GR 33343X xinafoate)

Salmeterol D12 Xinafoate saltQ: What is Salmeterol D12 Xinafoate salt Q: What is the CAS Number of Salmeterol D12 Xinafoate salt Q: What is the storage condition of Salmeterol D12 Xinafoate salt Q: What are the applications of Salmeterol D12 Xinafoate salt

Salmeterol Xinafoate-d3

Salmeterol XinafoateQ: What is Salmeterol Xinafoate Q: What is the CAS Number of Salmeterol Xinafoate Q: What is the storage condition of Salmeterol Xinafoate Q: What are the applications of Salmeterol Xinafoate

Salmeterol Xinafoate (1609603)

Salmeterol sinaphthate

Salmeterol xinafoate in Methanol

C16904920 SalmeteroLxinafoate

Salmeterol xinafoate, beta2 adrenoceptor agonist

94749-08-3

29213-08-3

C36H45NO7

C25H37NO4C11H8O3