ChemicalBook > CAS DataBase List > AC-YVAD-AFC

AC-YVAD-AFC

Product Name
AC-YVAD-AFC
CAS No.
219137-85-6
Chemical Name
AC-YVAD-AFC
Synonyms
AC-YVAD-AFC;AC-TYR-VAL-ALA-ASP-AFC;M.W. 719.67 C33H36F3N5O10;CASPASE-1 SUBSTRATE XII, FLUOROGENIC;CASPASE 1 (ICE) SUBSTRATE 2F, FLUOROGENIC;AC-TYR-VAL-ALA-ASP-7-AMINO-4-TRIFLUOROMETHYL COUMARIN;N-ACETYL-TYR-VAL-ALA-ASP 7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN;N-Acetyl-Tyr-Val-Ala-Asp-(7-amino-4-trifluoromethylcoumarin);Caspase-1 Substrate VI, Fluorogenic - CAS 219137-85-6 - Calbiochem;L-α-Asparagine, N-acetyl-L-tyrosyl-L-valyl-L-alanyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-
CBNumber
CB2753902
Molecular Formula
C33H36F3N5O10
Formula Weight
719.66
MOL File
219137-85-6.mol
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AC-YVAD-AFC Property

Melting point:
>190°C (dec.)
Boiling point:
1084.6±65.0 °C(Predicted)
Density 
1.416±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO (Slightly), Methanol (Silghtly)
form 
powder
pka
4.09±0.10(Predicted)
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A9965
Product name
N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin
Purity
≥95% (HPLC), powder
Packaging
1mg
Price
$178
Updated
2024/03/01
Sigma-Aldrich
Product number
688225
Product name
Caspase-1 Substrate VI, Fluorogenic
Purity
Fluorogenic caspase-1 substrate.
Packaging
5mg
Price
$293.4
Updated
2024/03/01
Cayman Chemical
Product number
17591
Product name
Ac-YVAD-AFC
Purity
≥98%
Packaging
1mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
17591
Product name
Ac-YVAD-AFC
Purity
≥98%
Packaging
5mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
17591
Product name
Ac-YVAD-AFC
Purity
≥98%
Packaging
10mg
Price
$220
Updated
2024/03/01
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AC-YVAD-AFC Chemical Properties,Usage,Production

Description

Ac-YVAD-AFC is a substrate whose amino acids YVAD have been shown to be a preferred cleavage site for caspase-1 and -4. Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.

Uses

N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin is a substrate whose amino acids are shown as a preferred cleavage site for Caspase-1 and 4. Useful for caspase research.

Definition

ChEBI: Ac-Tyr-Val-Ala-Asp-7-amino-4-trifluoromethylcoumarin is a tetrapeptide obtained by formal condensation of the C-terminal carboxy group of Ac-Tyr-Val-Ala-Asp with the amino group of 7-amino-4-trifluoromethylcoumarin. It has a role as a protease inhibitor. It is a tetrapeptide, a member of acetamides, a member of coumarins and an organofluorine compound. It is functionally related to a 7-amino-4-(trifluoromethyl)coumarin.

Biological Activity

Fluorogenic peptide substrate for caspase-1 (ICE).

AC-YVAD-AFC Preparation Products And Raw materials

Raw materials

Preparation Products

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219137-85-6, AC-YVAD-AFCRelated Search:

AC-YVAD-CHO AC-YVAD-AMC AC-YVAD-AFC

  • CASPASE 1 (ICE) SUBSTRATE 2F, FLUOROGENIC
  • AC-YVAD-AFC
  • AC-TYR-VAL-ALA-ASP-7-AMINO-4-TRIFLUOROMETHYL COUMARIN
  • AC-TYR-VAL-ALA-ASP-AFC
  • M.W. 719.67 C33H36F3N5O10
  • N-Acetyl-Tyr-Val-Ala-Asp-(7-amino-4-trifluoromethylcoumarin)
  • Caspase-1 Substrate VI, Fluorogenic - CAS 219137-85-6 - Calbiochem
  • N-ACETYL-TYR-VAL-ALA-ASP 7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN
  • CASPASE-1 SUBSTRATE XII, FLUOROGENIC
  • 4-[[4-(difluoromethyl)-2-oxochromen-7-yl]amino]-3-[2-(3-methylbutanoylamino)propanoylamino]-4-oxobutanoic acid
  • L-α-Asparagine, N-acetyl-L-tyrosyl-L-valyl-L-alanyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-
  • 219137-85-6
  • C33H36F3N5O10
  • C33H36N5O10F3
  • Caspase/Related Products
  • Pepetides
  • Caspases/Apoptosis
  • peptide