ChemicalBook > CAS DataBase List > AC-YVAD-AFC

AC-YVAD-AFC

Product Name: AC-YVAD-AFC
CAS No.: 219137-85-6
Chemical Name: AC-YVAD-AFC
Synonyms: AC-YVAD-AFC;AC-TYR-VAL-ALA-ASP-AFC;M.W. 719.67 C33H36F3N5O10;CASPASE-1 SUBSTRATE XII, FLUOROGENIC;CASPASE 1 (ICE) SUBSTRATE 2F, FLUOROGENIC;AC-TYR-VAL-ALA-ASP-7-AMINO-4-TRIFLUOROMETHYL COUMARIN;N-ACETYL-TYR-VAL-ALA-ASP 7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN;N-Acetyl-Tyr-Val-Ala-Asp-(7-amino-4-trifluoromethylcoumarin);Caspase-1 Substrate VI, Fluorogenic - CAS 219137-85-6 - Calbiochem;N-Acetyl-L-tyrosyl-L-valyl-L-alanyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine
CBNumber: CB2753902
Molecular Formula: C33H36F3N5O10
Formula Weight: 719.66
MOL File: 219137-85-6.mol

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AC-YVAD-AFC Property

Melting point:: >190°C (dec.)
Boiling point:: 1084.6±65.0 °C(Predicted)
Density: 1.416±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMSO (Slightly), Methanol (Silghtly)
form: powder
pka: 4.09±0.10(Predicted)
color: white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A9965
Product name: N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin
Purity: ≥95% (HPLC), powder
Packaging: 1mg
Price: $156
Updated: 2025/07/31

Sigma-Aldrich

Product number: 688225
Product name: Caspase-1 Substrate VI, Fluorogenic
Purity: Fluorogenic caspase-1 substrate.
Packaging: 5mg
Price: $503
Updated: 2025/07/31

Cayman Chemical

Product number: 17591
Product name: Ac-YVAD-AFC
Purity: ≥98%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 17591
Product name: Ac-YVAD-AFC
Purity: ≥98%
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 17591
Product name: Ac-YVAD-AFC
Purity: ≥98%
Packaging: 10mg
Price: $220
Updated: 2024/03/01

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AC-YVAD-AFC Chemical Properties,Usage,Production

Description

Ac-YVAD-AFC is a substrate whose amino acids YVAD have been shown to be a preferred cleavage site for caspase-1 and -4. Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.

Uses

N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin is a substrate whose amino acids are shown as a preferred cleavage site for Caspase-1 and 4. Useful for caspase research.

Definition

ChEBI: Ac-Tyr-Val-Ala-Asp-7-amino-4-trifluoromethylcoumarin is a tetrapeptide obtained by formal condensation of the C-terminal carboxy group of Ac-Tyr-Val-Ala-Asp with the amino group of 7-amino-4-trifluoromethylcoumarin. It has a role as a protease inhibitor. It is a tetrapeptide, a member of acetamides, a member of coumarins and an organofluorine compound. It is functionally related to a 7-amino-4-(trifluoromethyl)coumarin.

Biological Activity

Fluorogenic peptide substrate for caspase-1 (ICE).

References

[1] R V TALANIAN. Substrate specificities of caspase family proteases.[J]. The Journal of Biological Chemistry, 1997, 272 15: 9677-9682. DOI: 10.1074/jbc.272.15.9677
[2] M MARCELLI. Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP.[J]. Cancer research, 1998, 58 1: 76-83.

AC-YVAD-AFC Preparation Products And Raw materials

Raw materials

Preparation Products

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219137-85-6, AC-YVAD-AFCRelated Search:

AC-YVAD-CHO AC-YVAD-AMC AC-YVAD-AFC

CASPASE 1 (ICE) SUBSTRATE 2F, FLUOROGENIC

AC-YVAD-AFC

AC-TYR-VAL-ALA-ASP-7-AMINO-4-TRIFLUOROMETHYL COUMARIN

AC-TYR-VAL-ALA-ASP-AFC

M.W. 719.67 C33H36F3N5O10

N-Acetyl-Tyr-Val-Ala-Asp-(7-amino-4-trifluoromethylcoumarin)

Caspase-1 Substrate VI, Fluorogenic - CAS 219137-85-6 - Calbiochem

N-ACETYL-TYR-VAL-ALA-ASP 7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN

CASPASE-1 SUBSTRATE XII, FLUOROGENIC

4-[[4-(difluoromethyl)-2-oxochromen-7-yl]amino]-3-[2-(3-methylbutanoylamino)propanoylamino]-4-oxobutanoic acid

L-α-Asparagine, N-acetyl-L-tyrosyl-L-valyl-L-alanyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-

N-Acetyl-L-tyrosyl-L-valyl-L-alanyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine

(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-oxo-4-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]butanoic acid

219137-85-6

C33H36F3N5O10

C33H36N5O10F3

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