AC-YVAD-CHO
- Product Name
- AC-YVAD-CHO
- CAS No.
- 143313-51-3
- Chemical Name
- AC-YVAD-CHO
- Synonyms
- YVAD-CHO;L-709049;AC-YVAD-CHO;ICE INHIBITOR;ICE INHIBITOR I;AC-YVAD-ALDEHYDE;TYR-VAL-ALA-ASP-CHO;CASPASE INHIBITOR I;BIOTINYL-AC-YVAD-CHO;ACETYL-YVAD-ALDEHYDE
- CBNumber
- CB4158149
- Molecular Formula
- C23H32N4O8
- Formula Weight
- 492.52
- MOL File
- 143313-51-3.mol
AC-YVAD-CHO Property
- Boiling point:
- 937.7±65.0 °C(Predicted)
- Density
- 1.276±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMF:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
PBS (pH 7.2):5.0(Max Conc. mg/mL);10.15(Max Conc. mM) - pka
- 4.20±0.10(Predicted)
- form
- Powder
- color
- White to off-white
- Sensitive
- Moisture Sensitive
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 400010
- Product name
- Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem
- Purity
- The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.
- Packaging
- 1MG
- Price
- $99.4
- Updated
- 2024/03/01
- Product number
- 400010
- Product name
- Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem
- Purity
- The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.
- Packaging
- 5MG
- Price
- $432
- Updated
- 2024/03/01
- Product number
- J64407
- Product name
- Caspase-1 Inhibitor I
- Packaging
- 1mg
- Price
- $87.6
- Updated
- 2023/06/20
- Product number
- J64407
- Product name
- Caspase-1 Inhibitor I
- Packaging
- 5mg
- Price
- $308
- Updated
- 2023/06/20
- Product number
- 10016
- Product name
- Ac-YVAD-CHO
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
AC-YVAD-CHO Chemical Properties,Usage,Production
Description
Ac-YVAD-CHO is an inhibitor of caspase-1/interleukin-1β converting enzyme (ICE; Ki = 0.76 nM) and an acetylated form of the caspase-1 inhibitor YVAD-CHO . It is selective for caspase-1 over caspase-4, -5, -8, -9, and -10 (Kis = 163-970 nM), as well as over caspase-2, -3, -6, and -7 (Kis = >10,000 nM for all). It inhibits activation of caspase-1 and IL-1β in a cell-free assay using LPS-treated THP-1 cell homogenates when used at a concentration of 5 μM. Ac-YVAD-CHO (12.5 μmol/kg) reduces pancreatic levels of IL-18 and serum levels of IL-1β, as well as reduces pyroptosis of pancreatic cells, in a mouse model of cerulein-induced acute pancreatitis but does not decrease pancreatic expression of NOD-like receptor protein 3 (NLRP3). It increases susceptibility to lethal E. coli infection but prevents LPS-induced death in C3H/HeN mice when administered at doses of 5 and 10 mg/kg, respectively.
Uses
A potent, specific, and reversible inhibitor of caspases-1, -4 and -5
AC-YVAD-CHO Preparation Products And Raw materials
Raw materials
Preparation Products
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