AC-YVAD-CMK

Product Name: AC-YVAD-CMK
CAS No.: 178603-78-6
Chemical Name: AC-YVAD-CMK
Synonyms: AC-YVAD-CMK;ICE INHIBITOR II;CASPASE-1 INHIBITOR II;AC-TYR-VAL-ALA-ASP-CMK;AC-TYR-VAL-ALA-ASP-CH2CL;N-Ac-Tyr-Val-Ala-Asp-CMK;5-Trihydroxybenzoic acid;Ac-YVAD-cmk >=95% (HPLC);AC-YVAD-CHLOROMETHYLKETONE;AC-TYR-ALA-ASP-CHLOROMETHYLKETONE
CBNumber: CB0168634
Molecular Formula: C24H33ClN4O8
Formula Weight: 540.99
MOL File: 178603-78-6.mol

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AC-YVAD-CMK Property

Melting point:: >205°C (dec.)
RTECS: AY3079566
storage temp.: -20°C
solubility: DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
form: White solid
color: white to off-white
Stability:: Hygroscopic

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0429
Product name: Ac-YVAD-cmk
Purity: ≥95% (HPLC)
Packaging: 1mg
Price: $110
Updated: 2024/03/01

Sigma-Aldrich

Product number: 400012
Product name: Caspase-1 Inhibitor II
Packaging: 5mg
Price: $390
Updated: 2024/03/01

Alfa Aesar

Product number: J64226
Product name: Caspase-1 Inhibitor II
Packaging: 5mg
Price: $245
Updated: 2021/12/16

Cayman Chemical

Product number: 10014
Product name: Ac-YVAD-CMK
Purity: ≥98%
Packaging: 500μg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 10014
Product name: Ac-YVAD-CMK
Purity: ≥98%
Packaging: 1mg
Price: $71
Updated: 2024/03/01

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AC-YVAD-CMK Chemical Properties,Usage,Production

Uses

Ac-YVAD-CMK is a selective, irreversible inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1). Ac-YVAD-CMK is neuroprotective in a rat model of cerebral ischemia.[Cayman Chemical]

Uses

Ac-YVAD-cmk has been used:

as an inflammasome inhibitor to add to THP-1 cells or PBMC (peripheral blood mononuclear cell) before stimulation
as a caspase-1 inhibitor injected to C57BL/6 mice
as a caspase-1 inhibitor, administered into mice before and during hematopoietic stem cell transplantation (HSCT) to evaluate its effect on bone marrow inflammatory injury
to abolish the histidine-rich protein II (HRPII) effect on transendothelial electrical resistance (TEER)
as caspase 1 inhibitor, to treat MCF-7 tumor xenograft mice, to validate the role of inflammasomes activation in tumor growth?in vivo?condition

General Description

Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.

Biochem/physiol Actions

Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4. Ac-YVAD-cmk is anti-apoptotic and has anti-inflammatory and neuroprotective effects, thought to result from its preventing caspase-1 activation of the proinflammatory cytokine, Interleukin-1β.

AC-YVAD-CMK Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-YVAD-CMK Suppliers

China 92 India 1 Japan 2 Switzerland 2 United Kingdom 4 United States 17 USA 1 Global 119

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Hangzhou Beiputai Biopharmaceutical Co., Ltd

Tel: 0571-85350119 15888826472
Email: bptsales@163.com
Country: China
ProdList: 3851
Advantage: 58

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

178603-78-6, AC-YVAD-CMKRelated Search:

3-AMINO-PENTANOIC ACID HCL AC-YVAD-CHO H-TYR-GLY-NH2 HCL 5-Chlorovaleric acid H-ALA-VAL-NH2 HCL AC-YVAD-CMK BIOTINYLATED AC-YVAD-CMK

ICE INHIBITOR II

IL-1BETA CONVERTING ENZYME (ICE) INHIBITOR II

IL-1BETA CONVERTING ENZYME INHIBITOR II

INTERLEUKIN-1BETA (IL-1BETA) CONVERTING ENZYME (ICE) INHIBITOR II

CASPASE-1 INHIBITOR (CHLOROMETHYLKETONE)

CASPASE-1 INHIBITOR II

AC-TYR-ALA-ASP-CHLOROMETHYLKETONE

AC-TYR-VAL-ALA-ASP-CH2CL

AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE

AC-TYR-VAL-ALA-ASP-CMK

AC-YVAD-CHLOROMETHYLKETONE

AC-YVAD-CMK

(ACETYL-L-TYROSYL-L-VALYL-L-ALANYL-L-ASPART-1-YL)CHLOROMETHANE

N-ACETYL-TYR-VAL-ALA-ASP CHLOROMETHYL KETONE

N-ACETYL-L-TYROSYL-L-VALYL-N-[(1S)-1-(CARBOXYMETHYL)-3-CHLORO-2-OXOPROPYL]-L-ALANINAMIDE

interleukin-1B (1L-1B) converting*enzyme (ice) in

N-ACETYL-TYR-VAL-ALA-ASP CHLOROMETHYL KE

interleukin-1β (il-1β) converting enzyme (ice) inhibitor ii

INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITOR II

N-Ac-Tyr-Val-Ala-Asp-CMK

AC-TYR-VAL-ALA-ASP-CMK ; AC-YVKD-CMK

CASPASE 1 INHIBITOR II;AC-YVAD-CMK

Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem

L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-

(4S,7S,10S,13S)-13-(2-Chloroacetyl)-4-(4-hydroxybenzyl)-7-isopropyl-10-methyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid

5-Trihydroxybenzoic acid

Ac-YVAD-cmk >=95% (HPLC)

178603-78-6

C24H33ClN4O8

BioChemical

Apoptosis and Cell Cycle

Cell Signaling and Neuroscience

Caspase 1

Caspases

Cell Biology

Inhibitors

Caspase/Related Products

peptide

Pepetides

peptides

Elisa Kit-Mouse Elisa Kit