AC-YVAD-CMK
- Product Name
- AC-YVAD-CMK
- CAS No.
- 178603-78-6
- Chemical Name
- AC-YVAD-CMK
- Synonyms
- AC-YVAD-CMK;ICE INHIBITOR II;CASPASE-1 INHIBITOR II;AC-TYR-VAL-ALA-ASP-CMK;AC-TYR-VAL-ALA-ASP-CH2CL;N-Ac-Tyr-Val-Ala-Asp-CMK;5-Trihydroxybenzoic acid;Ac-YVAD-cmk >=95% (HPLC);AC-YVAD-CHLOROMETHYLKETONE;AC-TYR-ALA-ASP-CHLOROMETHYLKETONE
- CBNumber
- CB0168634
- Molecular Formula
- C24H33ClN4O8
- Formula Weight
- 540.99
- MOL File
- 178603-78-6.mol
AC-YVAD-CMK Property
- Melting point:
- >205°C (dec.)
- RTECS
- AY3079566
- storage temp.
- -20°C
- solubility
- DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
- form
- White solid
- color
- white to off-white
- Stability:
- Hygroscopic
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0429
- Product name
- Ac-YVAD-cmk
- Purity
- ≥95% (HPLC)
- Packaging
- 1mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 400012
- Product name
- Caspase-1 Inhibitor II
- Packaging
- 5mg
- Price
- $390
- Updated
- 2024/03/01
- Product number
- J64226
- Product name
- Caspase-1 Inhibitor II
- Packaging
- 5mg
- Price
- $245
- Updated
- 2021/12/16
- Product number
- 10014
- Product name
- Ac-YVAD-CMK
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $38
- Updated
- 2024/03/01
- Product number
- 10014
- Product name
- Ac-YVAD-CMK
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $71
- Updated
- 2024/03/01
AC-YVAD-CMK Chemical Properties,Usage,Production
Uses
Ac-YVAD-CMK is a selective, irreversible inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1). Ac-YVAD-CMK is neuroprotective in a rat model of cerebral ischemia.[Cayman Chemical]
Uses
Ac-YVAD-cmk has been used:
- as an inflammasome inhibitor to add to THP-1 cells or PBMC (peripheral blood mononuclear cell) before stimulation
- as a caspase-1 inhibitor injected to C57BL/6 mice
- as a caspase-1 inhibitor, administered into mice before and during hematopoietic stem cell transplantation (HSCT) to evaluate its effect on bone marrow inflammatory injury
- to abolish the histidine-rich protein II (HRPII) effect on transendothelial electrical resistance (TEER)
- as caspase 1 inhibitor, to treat MCF-7 tumor xenograft mice, to validate the role of inflammasomes activation in tumor growth?in vivo?condition
General Description
Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.
Biochem/physiol Actions
Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4. Ac-YVAD-cmk is anti-apoptotic and has anti-inflammatory and neuroprotective effects, thought to result from its preventing caspase-1 activation of the proinflammatory cytokine, Interleukin-1β.