ChemicalBook > CAS DataBase List > AC-YVAD-CMK

AC-YVAD-CMK

Product Name
AC-YVAD-CMK
CAS No.
178603-78-6
Chemical Name
AC-YVAD-CMK
Synonyms
AC-YVAD-CMK;ICE INHIBITOR II;CASPASE-1 INHIBITOR II;AC-TYR-VAL-ALA-ASP-CMK;AC-TYR-VAL-ALA-ASP-CH2CL;N-Ac-Tyr-Val-Ala-Asp-CMK;5-Trihydroxybenzoic acid;Ac-YVAD-cmk >=95% (HPLC);AC-YVAD-CHLOROMETHYLKETONE;AC-TYR-ALA-ASP-CHLOROMETHYLKETONE
CBNumber
CB0168634
Molecular Formula
C24H33ClN4O8
Formula Weight
540.99
MOL File
178603-78-6.mol
More
Less

AC-YVAD-CMK Property

Melting point:
>205°C (dec.)
RTECS 
AY3079566
storage temp. 
-20°C
solubility 
DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
form 
White solid
color 
white to off-white
Stability:
Hygroscopic
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0429
Product name
Ac-YVAD-cmk
Purity
≥95% (HPLC)
Packaging
1mg
Price
$110
Updated
2024/03/01
Sigma-Aldrich
Product number
400012
Product name
Caspase-1 Inhibitor II
Packaging
5mg
Price
$390
Updated
2024/03/01
Alfa Aesar
Product number
J64226
Product name
Caspase-1 Inhibitor II
Packaging
5mg
Price
$245
Updated
2021/12/16
Cayman Chemical
Product number
10014
Product name
Ac-YVAD-CMK
Purity
≥98%
Packaging
500μg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
10014
Product name
Ac-YVAD-CMK
Purity
≥98%
Packaging
1mg
Price
$71
Updated
2024/03/01
More
Less

AC-YVAD-CMK Chemical Properties,Usage,Production

Uses

Ac-YVAD-CMK is a selective, irreversible inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1). Ac-YVAD-CMK is neuroprotective in a rat model of cerebral ischemia.[Cayman Chemical]

Uses

Ac-YVAD-cmk has been used:

  • as an inflammasome inhibitor to add to THP-1 cells or PBMC (peripheral blood mononuclear cell) before stimulation
  • as a caspase-1 inhibitor injected to C57BL/6 mice
  • as a caspase-1 inhibitor, administered into mice before and during hematopoietic stem cell transplantation (HSCT) to evaluate its effect on bone marrow inflammatory injury
  • to abolish the histidine-rich protein II (HRPII) effect on transendothelial electrical resistance (TEER)
  • as caspase 1 inhibitor, to treat MCF-7 tumor xenograft mice, to validate the role of inflammasomes activation in tumor growth?in vivo?condition

General Description

Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.

Biochem/physiol Actions

Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4. Ac-YVAD-cmk is anti-apoptotic and has anti-inflammatory and neuroprotective effects, thought to result from its preventing caspase-1 activation of the proinflammatory cytokine, Interleukin-1β.

AC-YVAD-CMK Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

AC-YVAD-CMK Suppliers

China 87 India 1 Japan 2 Switzerland 2 United Kingdom 4 United States 16 USA 1 Global 113
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11289
Advantage
58
Hangzhou Beiputai Biopharmaceutical Co., Ltd
Tel
0571-85350119 13305819357
Email
bptsales@163.com
Country
China
ProdList
3579
Advantage
58
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15421
Advantage
60
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3421
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Shanghai Chaolan Chemical Technology Center
Tel
QQ:65489617 15618227136
Fax
21-5161 9052
Email
info@SuperLan-chem.com
Country
China
ProdList
9445
Advantage
58
Nanjing Peptide Biotech Ltd.
Tel
025-58361106-805 13082558573
Fax
025-58361106-806
Email
liugang@njpeptide.com
Country
China
ProdList
9961
Advantage
55
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
eric@peptidego.com
Country
China
ProdList
6347
Advantage
58
Alpha Biopharmaceuticals Co., Ltd
Tel
0411-39042497
Fax
0411-39042693
Email
sales@alphabiopharm.com
Country
China
ProdList
1951
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6870
Advantage
58
Beijing Minruida Technology Co., Ltd.
Tel
010-82387566 18001021521;
Fax
82387566-801
Email
sales@mreda.com.cn
Country
China
ProdList
21450
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19105
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10523
Advantage
58
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19915
Advantage
58
Henan Weituxi Chemical Technology Co., Ltd.
Tel
0371-63284658; 18135795563
Fax
QQ:2885349392
Email
2885349392@qq.com
Country
China
ProdList
9997
Advantage
58
Shanghai Lanle Bird Industrial Co., Ltd.
Tel
15021845385
Email
765325601@qq.com
Country
China
ProdList
3611
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9414
Advantage
58
Shanghai Kanglang Biotechnology Co., Ltd.
Tel
021-61998208 18217752821
Fax
021-37680378
Email
sales@klbio.cn
Country
China
ProdList
9617
Advantage
58
Guangzhou Younan Technology Co., Ltd
Tel
020-020-82000279 18988968278
Fax
QQ：3283937693
Email
sales@ubiochem.com
Country
China
ProdList
2357
Advantage
58
Wuxi Helen Biotechnology Co., Ltd.,
Tel
0510-85629785 18013409632
Fax
0510-85625359
Email
sales@reading-chemicals.com
Country
China
ProdList
14092
Advantage
58
Nanjing TGpeptide Biotechnology Co.,Ltd.
Tel
18115476705
Email
sales@tgpeptide.com
Country
China
ProdList
3189
Advantage
58
Wuhan Chemstan Biotechnology Co., Ltd.
Tel
15926423062
Fax
QQ：422450190
Email
422450190@qq.com
Country
China
ProdList
10132
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8141
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44941
Advantage
58
DONBOO AMINO ACID COMPANY
Tel
+8613063595538
Email
donboo@donboo.com
Country
China
ProdList
9365
Advantage
58
Shanghai fantai biology science and technology co., ltd
Tel
15601885736
Email
2114786541@qq.com
Country
China
ProdList
206
Advantage
58
TCI (Shanghai) Chemical Trading Co., Ltd.
Tel
021-61109150
Fax
021-61105897
Email
sales@tcisct.com
Country
China
ProdList
31163
Advantage
58
Shanghai Universal Biotech Co.,Ltd
Tel
18768175414
Email
gaojun@univ-bio.com
Country
China
ProdList
24998
Advantage
58
amyjetsci
Tel
027-59626688 18771149750
Email
sales@amyjet.com
Country
China
ProdList
3004
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Email
product02@bidepharm.com
Country
China
ProdList
61720
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6712
Advantage
58
Nanjing Yuanpeptide Biotech Co.，Ltd.
Tel
18168071971
Email
support@yuan-peptide.com
Country
China
ProdList
2977
Advantage
58
hangzhoubaiyibiolog
Tel
--
Fax
--
Email
sales@hzbybio.com
Country
China
ProdList
22
Advantage
58
Shaoxing Junyu Biotechnology Co., LTD
Tel
0571-88211921 15572296305
Email
sales4@gotopbio.com
Country
China
ProdList
5144
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
29803
Advantage
58
Hubei Aiputi Bioengineering Co., Ltd.
Tel
17762444226
Email
d17762444226@163.com
Country
China
ProdList
2402
Advantage
58
Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
Email
sales@chemlab-tachizaki.com
Country
China
ProdList
2488
Advantage
58
Shanghai Yiyan Biotechnology Co. , Ltd.
Tel
021-69985186 13611928337
Email
3427709316@qq.com
Country
China
ProdList
7984
Advantage
58
Hangzhou Baige Pharmaceutical Technology Co. , Ltd.
Tel
0571-85350119 15888826472
Email
15888826472@163.com
Country
China
ProdList
2729
Advantage
58
Hubei ipodix Biotech Technology Co., Ltd
Tel
18007124176
Email
ipdshengwu@163.com
Country
China
ProdList
4801
Advantage
58
Shanghai HongTide Biotechnology Co.,Ltd.
Tel
19961912513
Email
sales@hongtide.com
Country
China
ProdList
4528
Advantage
58
Shanghai Guchen Biotechnology Co., LTD
Tel
021-34675735 19147740836
Email
1986399151@qq.com
Country
China
ProdList
9849
Advantage
58
Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd
Tel
18014456767 18014456767
Email
wenxi@jszkhy.com
Country
China
ProdList
1349
Advantage
58
Jinan Sanbao Biotechnology Co., Ltd.
Tel
13854185395; 13854185395
Email
sanbaobiotech@126.com
Country
China
ProdList
8453
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 17801761073
Email
Gsiyu@solarbio.com
Country
China
ProdList
50751
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
8740
Advantage
58

178603-78-6, AC-YVAD-CMKRelated Search:

3-AMINO-PENTANOIC ACID HCL AC-YVAD-CHO H-TYR-GLY-NH2 HCL 5-Chlorovaleric acid H-ALA-VAL-NH2 HCL AC-YVAD-CMK BIOTINYLATED AC-YVAD-CMK

  • ICE INHIBITOR II
  • IL-1BETA CONVERTING ENZYME (ICE) INHIBITOR II
  • IL-1BETA CONVERTING ENZYME INHIBITOR II
  • INTERLEUKIN-1BETA (IL-1BETA) CONVERTING ENZYME (ICE) INHIBITOR II
  • CASPASE-1 INHIBITOR (CHLOROMETHYLKETONE)
  • CASPASE-1 INHIBITOR II
  • AC-TYR-ALA-ASP-CHLOROMETHYLKETONE
  • AC-TYR-VAL-ALA-ASP-CH2CL
  • AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE
  • AC-TYR-VAL-ALA-ASP-CMK
  • AC-YVAD-CHLOROMETHYLKETONE
  • AC-YVAD-CMK
  • (ACETYL-L-TYROSYL-L-VALYL-L-ALANYL-L-ASPART-1-YL)CHLOROMETHANE
  • N-ACETYL-TYR-VAL-ALA-ASP CHLOROMETHYL KETONE
  • N-ACETYL-L-TYROSYL-L-VALYL-N-[(1S)-1-(CARBOXYMETHYL)-3-CHLORO-2-OXOPROPYL]-L-ALANINAMIDE
  • interleukin-1B (1L-1B) converting*enzyme (ice) in
  • N-ACETYL-TYR-VAL-ALA-ASP CHLOROMETHYL KE
  • interleukin-1β (il-1β) converting enzyme (ice) inhibitor ii
  • INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITOR II
  • N-Ac-Tyr-Val-Ala-Asp-CMK
  • AC-TYR-VAL-ALA-ASP-CMK ; AC-YVKD-CMK
  • CASPASE 1 INHIBITOR II;AC-YVAD-CMK
  • Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem
  • L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-
  • (4S,7S,10S,13S)-13-(2-Chloroacetyl)-4-(4-hydroxybenzyl)-7-isopropyl-10-methyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid
  • 5-Trihydroxybenzoic acid
  • Ac-YVAD-cmk >=95% (HPLC)
  • 178603-78-6
  • C24H33ClN4O8
  • BioChemical
  • Apoptosis and Cell Cycle
  • Cell Signaling and Neuroscience
  • Caspase 1
  • Caspases
  • Cell Biology
  • Inhibitors
  • Caspase/Related Products
  • peptide
  • Pepetides
  • peptides
  • Elisa Kit-Mouse Elisa Kit