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AC-YVAD-CHO

Product Name
AC-YVAD-CHO
CAS No.
143313-51-3
Chemical Name
AC-YVAD-CHO
Synonyms
YVAD-CHO;L-709049;AC-YVAD-CHO;ICE INHIBITOR;ICE INHIBITOR I;AC-YVAD-ALDEHYDE;TYR-VAL-ALA-ASP-CHO;CASPASE INHIBITOR I;BIOTINYL-AC-YVAD-CHO;ACETYL-YVAD-ALDEHYDE
CBNumber
CB4158149
Molecular Formula
C23H32N4O8
Formula Weight
492.52
MOL File
143313-51-3.mol
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AC-YVAD-CHO Property

Boiling point:
937.7±65.0 °C(Predicted)
Density 
1.276±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMF:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
PBS (pH 7.2):5.0(Max Conc. mg/mL);10.15(Max Conc. mM)
pka
4.20±0.10(Predicted)
form 
Powder
Sensitive 
Moisture Sensitive
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
400010
Product name
Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem
Purity
The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.
Packaging
1MG
Price
$99.4
Updated
2024/03/01
Sigma-Aldrich
Product number
400010
Product name
Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem
Purity
The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.
Packaging
5MG
Price
$432
Updated
2024/03/01
Alfa Aesar
Product number
J64407
Product name
Caspase-1 Inhibitor I
Packaging
1mg
Price
$87.6
Updated
2023/06/20
Alfa Aesar
Product number
J64407
Product name
Caspase-1 Inhibitor I
Packaging
5mg
Price
$308
Updated
2023/06/20
Cayman Chemical
Product number
10016
Product name
Ac-YVAD-CHO
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
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AC-YVAD-CHO Chemical Properties,Usage,Production

Description

Ac-YVAD-CHO is an inhibitor of caspase-1/interleukin-1β converting enzyme (ICE; Ki = 0.76 nM) and an acetylated form of the caspase-1 inhibitor YVAD-CHO . It is selective for caspase-1 over caspase-4, -5, -8, -9, and -10 (Kis = 163-970 nM), as well as over caspase-2, -3, -6, and -7 (Kis = >10,000 nM for all). It inhibits activation of caspase-1 and IL-1β in a cell-free assay using LPS-treated THP-1 cell homogenates when used at a concentration of 5 μM. Ac-YVAD-CHO (12.5 μmol/kg) reduces pancreatic levels of IL-18 and serum levels of IL-1β, as well as reduces pyroptosis of pancreatic cells, in a mouse model of cerulein-induced acute pancreatitis but does not decrease pancreatic expression of NOD-like receptor protein 3 (NLRP3). It increases susceptibility to lethal E. coli infection but prevents LPS-induced death in C3H/HeN mice when administered at doses of 5 and 10 mg/kg, respectively.

Uses

A potent, specific, and reversible inhibitor of caspases-1, -4 and -5

AC-YVAD-CHO Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-YVAD-CHO Suppliers

China 66 France 1 Japan 2 Switzerland 2 United Kingdom 3 United States 17 USA 1 Global 92

143313-51-3, AC-YVAD-CHORelated Search:

AC-LYS(AC)-D-ALA-D-ALA-OH AC-WEHD-AMC AC-ESMD-CHO AC-WEHD-CHO ICE INHIBITOR IV N-acetyl-N-methyl-L-tyrosyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-L-Alaninamide AC-TYR-VAL-LYS(BIOTINYL)-ASP-2,6-DIMETHYLBENZOYLOXYMETHYLKETONE ASN-GLU-ALA-TYR-VAL-HIS-ASP-ALA-PRO-VAL-ARG-SER-LEU-ASN AC-YVAD-AFC DABCYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-EDANS AC-YVAD-CMK AC-TYR-(NME)VAL-ALA-(NME)ASP-CHO MCA-TYR-VAL-ALA-ASP-ALA-PRO-LYS(DNP)-OH AC-YVAD-PNA N-ACETYL-TYR-VAL-LYS-ASP-AL AC-YVAD-AMC ICE INHIBITOR II, BIOTINYLATED,IL-1BETA CONVERTING ENZYME (ICE) INHIBITOR II, BIOTINYLATED BIOTIN-TYR-VAL-ALA-ASP-CHO

  • N-ACETYL-L-TYROSYL-L-VALYL-N-[(1S)-2-CARBOXYL-1-FORMYLETHYL]-L-ALANINAMIDE
  • N-ACETYL-TYR-VAL-ALA-ASP-CHO (ALDEHYDE)
  • N-ACETYL-TYR-VAL-ALA-GLU-AL
  • N-AC-TYR-VAL-ALA-ASP-CHO
  • N-ACETYL-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-TYR-VAL-ALA-ASP-CHO (ALDEHYDE)
  • TYR-VAL-ALA-ASP-CHO
  • YVAD-CHO
  • ICE INHIBITOR
  • ICE INHIBITOR I
  • IL-1BETA CONVERTING ENZYME (ICE) INHIBITOR I
  • IL-1BETA CONVERTING ENZYME INHIBITOR I
  • IL-1BETA CONVERTING ENZYME INHIBITOR
  • L-709049
  • CASPASE INHIBITOR I
  • CASPASE 1 (ICE) INHIBITOR I
  • CASPASE-1 INHIBITOR (ALDEHYDE)
  • CASPASE-1 INHIBITOR I
  • CELL-PERMEABLE YVAD-CHO
  • BIOTINYL-AC-YVAD-CHO
  • BIOTINYL-AC-TYR-VAL-ALA-ASP-CHO
  • ACETYL-TYR-VAL-ALA-ASP-ALDEHYDE
  • ACETYL-YVAD-ALDEHYDE
  • ACETYL-L-TYROSYL-L-VALYL-L-ALANYL-L-ASPART-1-AL
  • AC-TYR-VAL-ALA-ASP-H (ALDEHYDE)
  • AC-YVAD-ALDEHYDE
  • AC-YVAD-CHO
  • AC-TYR-VAL-ALA-ASP-ALDEHYDE
  • AC-TYR-VAL-ALA-ASP-ALDEHYDE (PSEUDO ACID)
  • AC-TYR-VAL-ALA-ASP-CHO
  • ACETYL-YVAD ALDEHYDE L-709,049, SYNTHETI C
  • ICE (CASPASE I) INHIBITOR I
  • Caspase 1 (ICE) Inhibitor 2
  • N-acetyl-Tyr-Val-Ala-aspartinal
  • Acetyl-tyrosyl-valyl-alanyl-aspartal
  • N-Acetyl-Tyr-Val-Ala-Asp-al
  • (S)-N-Acetyl-L-tyrosyl-L-valyl-N-(2-carboxy-1-formylethyl)-L-alaninamide
  • Acetyl-tyrosyl-valyl-alanyl-aspartinal
  • Acetyl-Tyr-Val-Ala-Asp-cho
  • Ac-YVAD-CHO, L-709049
  • L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-
  • AC-YVAD-CHO USP/EP/BP
  • Ac-YVAD-CHO (N-Ac-Tyr-Val-Ala-Asp-CHO)
  • N-Ac-Tyr-Val-Ala-Asp-Aldehyde
  • 143313-51-3
  • C23H32N4O8
  • Biochemicals and Reagents
  • BioChemical
  • Amino Acids and Peptides
  • Other Peptides
  • Peptides
  • Caspases/Apoptosis
  • peptide
  • Pepetides
  • peptides