AC-YVAD-AFC
- Product Name
- AC-YVAD-AFC
- CAS No.
- 219137-85-6
- Chemical Name
- AC-YVAD-AFC
- Synonyms
- AC-YVAD-AFC;AC-TYR-VAL-ALA-ASP-AFC;M.W. 719.67 C33H36F3N5O10;CASPASE-1 SUBSTRATE XII, FLUOROGENIC;CASPASE 1 (ICE) SUBSTRATE 2F, FLUOROGENIC;AC-TYR-VAL-ALA-ASP-7-AMINO-4-TRIFLUOROMETHYL COUMARIN;N-ACETYL-TYR-VAL-ALA-ASP 7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN;N-Acetyl-Tyr-Val-Ala-Asp-(7-amino-4-trifluoromethylcoumarin);Caspase-1 Substrate VI, Fluorogenic - CAS 219137-85-6 - Calbiochem;L-α-Asparagine, N-acetyl-L-tyrosyl-L-valyl-L-alanyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-
- CBNumber
- CB2753902
- Molecular Formula
- C33H36F3N5O10
- Formula Weight
- 719.66
- MOL File
- 219137-85-6.mol
AC-YVAD-AFC Property
- Melting point:
- >190°C (dec.)
- Boiling point:
- 1084.6±65.0 °C(Predicted)
- Density
- 1.416±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO (Slightly), Methanol (Silghtly)
- form
- powder
- pka
- 4.09±0.10(Predicted)
- color
- white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- A9965
- Product name
- N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin
- Purity
- ≥95% (HPLC), powder
- Packaging
- 1mg
- Price
- $178
- Updated
- 2024/03/01
- Product number
- 688225
- Product name
- Caspase-1 Substrate VI, Fluorogenic
- Purity
- Fluorogenic caspase-1 substrate.
- Packaging
- 5mg
- Price
- $293.4
- Updated
- 2024/03/01
- Product number
- 17591
- Product name
- Ac-YVAD-AFC
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $38
- Updated
- 2024/03/01
- Product number
- 17591
- Product name
- Ac-YVAD-AFC
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 17591
- Product name
- Ac-YVAD-AFC
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $220
- Updated
- 2024/03/01
AC-YVAD-AFC Chemical Properties,Usage,Production
Description
Ac-YVAD-AFC is a substrate whose amino acids YVAD have been shown to be a preferred cleavage site for caspase-1 and -4. Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-
Uses
N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin is a substrate whose amino acids are shown as a preferred cleavage site for Caspase-1 and 4. Useful for caspase research.
Definition
ChEBI: Ac-Tyr-Val-Ala-Asp-7-amino-4-trifluoromethylcoumarin is a tetrapeptide obtained by formal condensation of the C-terminal carboxy group of Ac-Tyr-Val-Ala-Asp with the amino group of 7-amino-4-trifluoromethylcoumarin. It has a role as a protease inhibitor. It is a tetrapeptide, a member of acetamides, a member of coumarins and an organofluorine compound. It is functionally related to a 7-amino-4-(trifluoromethyl)coumarin.
Biological Activity
Fluorogenic peptide substrate for caspase-1 (ICE).