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AC-IEPD-PNA

Product Name
AC-IEPD-PNA
CAS No.
216757-29-8
Chemical Name
AC-IEPD-PNA
Synonyms
AC-IEPD-PNA;AC-ILE-GLU-PRO-ASP-PNA;AC-ILE-GLU-PRO-ASP-PARANITROANILIDE;N-ACETYL-ILE-GLU-PRO-ASP-P-NITROANILINE;N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide;GRANZYME B SUBSTRATE VIII, COLORIMETRIC;N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide;N-ACETYL-ILE-GLU-PRO-ASP-P-NITROANILIDE;AC-IETD-PNA;L-α-Asparagine, N-acetyl-L-isoleucyl-L-α-glutamyl-L-prolyl-N-(4-nitrophenyl)- (9CI)
CBNumber
CB2762317
Molecular Formula
C28H38N6O11
Formula Weight
634.63
MOL File
216757-29-8.mol
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AC-IEPD-PNA Property

Boiling point:
1096.9±65.0 °C(Predicted)
Density 
1.386±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO: soluble
form 
powder
pka
4.06±0.10(Predicted)
color 
White to off-white
Sequence
Ac-Ile-Glu-Pro-Asp-{pNA}
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A6470
Product name
N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide
Purity
≥97% (HPLC), powder
Packaging
5MG
Price
$455
Updated
2025/07/31
Sigma-Aldrich
Product number
368067-M
Product name
Granzyme B Substrate VIII, Colorimetric
Purity
A colorimetric substrate for granzyme B (kcat</sub>/Km</sub> = 6.6 x 10&#8308; M&#8315;&#185;s&#8315;&#185;).
Packaging
1 unit
Price
$141
Updated
2025/07/31
Biosynth Carbosynth
Product number
FA110813
Product name
Ac-Ile-Glu-Pro-Asp-pNA
Packaging
5mg
Price
$236
Updated
2021/12/16
AK Scientific
Product number
2152CJ
Product name
Ac-Ile-Glu-Pro-Asp-PNA
Packaging
5mg
Price
$368
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA110813
Product name
Ac-Ile-Glu-Pro-Asp-pNA
Packaging
10mg
Price
$411
Updated
2021/12/16
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AC-IEPD-PNA Chemical Properties,Usage,Production

Uses

N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide (Ac-IEPD-pNA) is a granzyme B substrate that allows accurate measurement of granzyme B activity[1].

Biological Activity

Primary Target
Colorimetric substrate for granzyme B', 'kcat/Km = 6.6 x 104 M-¹ sec-¹ as substrate for granzyme B

References

[1] Kristina Fritsch, et al. Suppression of granzyme B activity and caspase-3 activation in leukaemia cells constitutively expressing the protease inhibitor 9. Ann Hematol. 2013 Dec;92(12):1603-9. DOI:10.1007/s00277-013-1846-6

AC-IEPD-PNA Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-IEPD-PNA Suppliers

China 82 Switzerland 2 United Kingdom 2 United States 8 Global 94
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216757-29-8, AC-IEPD-PNARelated Search:

GRANZYME B AC-ASP-PNA AC-IEPD-PNA

  • N-ACETYL-ILE-GLU-PRO-ASP-P-NITROANILINE
  • AC-IEPD-PNA
  • AC-ILE-GLU-PRO-ASP-PARANITROANILIDE
  • AC-ILE-GLU-PRO-ASP-PNA
  • N-ACETYL-ILE-GLU-PRO-ASP-P-NITROANILIDE;AC-IETD-PNA
  • GRANZYME B SUBSTRATE VIII, COLORIMETRIC
  • N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide
  • L-α-Asparagine, N-acetyl-L-isoleucyl-L-α-glutamyl-L-prolyl-N-(4-nitrophenyl)- (9CI)
  • N-Acetyl-Ile-Glu-Pro-Asp-<i>p</i>-nitroanilide
  • 216757-29-8
  • C28H38N6O11
  • Pepetides