4-NITROBENZENESULFONYL FLUORIDE
- Product Name
- 4-NITROBENZENESULFONYL FLUORIDE
- CAS No.
- 349-96-2
- Chemical Name
- 4-NITROBENZENESULFONYL FLUORIDE
- Synonyms
- 4-NITROBENZENESULFONYL FLUORIDE;4-Nitrobenzenesulphonyl fluoride;Benzenesulfonylfluoride, 4-nitro-;4-Nitrobenzene-1-sulfonyl fluoride;4-Nitrobenzenesulfonyl fluoride,99%;4-NITROBENZENESULFONYL FLUORIDE 99%;4-Nitrobenzenesulfonyl fluoride, 99% 5GR
- CBNumber
- CB2765444
- Molecular Formula
- C6H4FNO4S
- Formula Weight
- 205.16
- MOL File
- 349-96-2.mol
4-NITROBENZENESULFONYL FLUORIDE Property
- Melting point:
- 76-80 °C
- Boiling point:
- 305.1±25.0 °C(Predicted)
- Density
- 1.5663 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Crystalline Powder
- color
- Yellow
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 45-36/37/39-26-27
- RIDADR
- 1759
- WGK Germany
- 3
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29049090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- ALD00036
- Product name
- 4-Nitrobenzenesulfonyl fluoride
- Purity
- 95%
- Packaging
- 1g
- Price
- $156
- Updated
- 2025/07/31
- Product number
- N493540
- Product name
- 4-Nitrobenzenesulfonyl fluoride
- Packaging
- 1g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 285930
- Product name
- 4-Nitrobenzenesulfonyl Fluoride
- Packaging
- 1g
- Price
- $337
- Updated
- 2021/12/16
- Product number
- 090691
- Product name
- 4-Nitrobenzene-1-sulfonyl fluoride
- Purity
- 95+%
- Packaging
- 5g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 8662-3-02
- Product name
- 4-Nitrobenzenesulfonyl fluoride
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
4-NITROBENZENESULFONYL FLUORIDE Chemical Properties,Usage,Production
Chemical Properties
yellow crystalline powder
Uses
Sulfonyl fluoride motif can be used as a connector for the assembly of -SO2- linked small molecules with proteins or nucleic acids. This new click chemistry approach through sulfates is a complimentary approach to using amides and phosphate groups as linkers.
Uses
4-Nitrobenzenesulfonyl Fluoride is a protein modifying agent shown to be specific for tyrosine.
reaction suitability
reaction type: click chemistry
Synthesis
98-74-8
349-96-2
The general procedure for the synthesis of p-nitrobenzene methanesulfonyl fluoride from 4-nitrobenzene-1-sulfonyl chloride was as follows: potassium fluoride (KF, 26.0 g, 451 mmol) and 18-crown-6 (1.2 g, 4.5 mmol) were added to a 500 mL solution of 4-nitrobenzene-1-sulfonyl chloride (20.0 g, 90.2 mmol) in acetonitrile (CH3CN). The reaction mixture was stirred at room temperature for 24 h before the solvent was evaporated to dryness by rotary evaporator. Subsequently, ethyl acetate (EtOAc, 600 mL) was added to the residue for dissolution. The resulting solution was washed sequentially with deionized water (H2O, 300 mL × 3) and saturated brine (300 mL). The organic layer was dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated in vacuum to give p-nitrobenzene methanesulfonyl fluoride (17.4 g, 94% yield) as a yellow solid with a melting point of 76-77 °C. Thin layer chromatography (TLC) showed an Rf value of 0.63 (Expanding agent: hexane/ethyl acetate = 6/4). Nuclear magnetic resonance hydrogen spectrum (1H NMR, 400MHz, CDCl3): δ8.47 (d, J=8.7Hz, 2H, aromatic-H), 8.25 (d, J=8.7Hz, 2H, aromatic-H); nuclear magnetic resonance carbon spectrum (13C NMR, 100MHz, CDCl3): δ151.8 (C), 138.2 (d, J=26.7Hz (C), 130.0 (CH), 124.9 (CH); nuclear magnetic resonance fluorine spectrum (19F NMR, 376MHz, CDCl3): δ65.1. infrared spectrum (IR, KBr): 3105,2872,1951,1818,1613,1540,1420,1354,1314,1215 cm-1. high resolution mass spectrometry (HRMS) calculated values C (HRMS) calculated value of C6H5FNO4S ([M+H]+) was 205.9923 and measured value was 205.9918.
References
[1] Tetrahedron, 2016, vol. 72, # 1, p. 58 - 68
[2] ACS Combinatorial Science, 2018, vol. 20, # 11, p. 672 - 680
[3] Journal of Fluorine Chemistry, 2013, vol. 145, p. 35 - 40
[4] Organic and Biomolecular Chemistry, 2017, vol. 15, # 45, p. 9685 - 9695
[5] Journal of Organic Chemistry, 2013, vol. 78, # 22, p. 11262 - 11270
4-NITROBENZENESULFONYL FLUORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
4-NITROBENZENESULFONYL FLUORIDE Suppliers
- Tel
- 1-516-6625404
- Fax
- 1-516-927-0118
- support@alfa-chemistry.com
- Country
- United States
- ProdList
- 9171
- Advantage
- 60
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52923
- Advantage
- 58
- Tel
- +1-817863-6948 +1-（817）863-6948
- sales@aceschem.com
- Country
- United States
- ProdList
- 19632
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@synquestlabs.com
- Country
- United States
- ProdList
- 6871
- Advantage
- 62
- Tel
- --
- Fax
- --
- Country
- United States
- ProdList
- 6773
- Advantage
- 87
- Tel
- --
- Fax
- --
- sales@matrixscientific.com
- Country
- United States
- ProdList
- 6632
- Advantage
- 80
- Tel
- --
- Fax
- --
- chemical@indofinechemical.com
- Country
- United States
- ProdList
- 6176
- Advantage
- 69
- Tel
- --
- Fax
- --
- sales@honestjoy.cn
- Country
- United States
- ProdList
- 6675
- Advantage
- 54
- Tel
- --
- Fax
- --
- sales@3bsc.com
- Country
- United States
- ProdList
- 6718
- Advantage
- 47
View Lastest Price from 4-NITROBENZENESULFONYL FLUORIDE manufacturers
- Product
- 4-NITROBENZENESULFONYL FLUORIDE 349-96-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2020-03-06