4-Nitrothiophenol
- Product Name
- 4-Nitrothiophenol
- CAS No.
- 1849-36-1
- Chemical Name
- 4-Nitrothiophenol
- Synonyms
- 4-NITROBENZENETHIOL;P-NITROTHIOPHENOL;4-NITROTHIOPHENOL;P-NITROBENZOLTHIOL;4-Nitrobenzolthiol;4-nitro-benzenethio;p-nitro-benzenethio;P-NITROBENZENETHIOL;4-nitrothiophenolate;PARA-NITROTHIOPHENOL
- CBNumber
- CB3682452
- Molecular Formula
- C6H5NO2S
- Formula Weight
- 155.17
- MOL File
- 1849-36-1.mol
4-Nitrothiophenol Property
- Melting point:
- 72-77 °C (lit.)
- Boiling point:
- 281.9±23.0 °C(Predicted)
- Density
- 1.357 (estimate)
- refractive index
- 1.5380 (estimate)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- pka
- 4.68±0.10(Predicted)
- form
- Crystalline Powder and/or Chunks
- color
- Yellow
- Water Solubility
- Partly soluble in water and chloroform.
- Sensitive
- Stench
- BRN
- 606924
- InChI
- 1S/C6H5NO2S/c8-7(9)5-1-3-6(10)4-2-5/h1-4,10H
- InChIKey
- AXBVSRMHOPMXBA-UHFFFAOYSA-N
- SMILES
- [O-][N+](=O)c1ccc(S)cc1
- CAS DataBase Reference
- 1849-36-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzenethiol, 4-nitro-(1849-36-1)
- EPA Substance Registry System
- 4-Nitrothiophenol (1849-36-1)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- RIDADR
- UN 3335
- WGK Germany
- 3
- RTECS
- DC1850000
- F
- 9-13-23
- Hazard Note
- Harmful/Irritant/Stench
- HazardClass
- IRRITANT
- HS Code
- 29309090
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N27209
- Product name
- 4-Nitrothiophenol
- Purity
- technical grade, 80%
- Packaging
- 5g
- Price
- $107.35
- Updated
- 2025/07/31
- Product number
- N27209
- Product name
- 4-Nitrothiophenol
- Purity
- technical grade, 80%
- Packaging
- 25g
- Price
- $396
- Updated
- 2025/07/31
- Product number
- N0146
- Product name
- 4-Nitrobenzenethiol
- Purity
- >95.0%(GC)(T)
- Packaging
- 5g
- Price
- $57
- Updated
- 2025/07/31
- Product number
- N0146
- Product name
- 4-Nitrobenzenethiol
- Purity
- >95.0%(GC)(T)
- Packaging
- 25g
- Price
- $194
- Updated
- 2025/07/31
- Product number
- N565520
- Product name
- 4-Nitrothiophenol(ContainsDimer)
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
4-Nitrothiophenol Chemical Properties,Usage,Production
Chemical Properties
yellow crystalline powder and/or chunks
Uses
4-Nitrothiophenol has been used in the synthesis of dual emission fluorescent probe for the differential sensing of of glutathione (GSH) and cysteine/homocysteine (Cys/Hcy). pNTP can also be used to synthesize diaryl thioethers via copper-catalyzed C-S coupling reaction.
Research
A 4-nitrothiophenol (4-NTP, Ar-NO2) modified electrode was prepared by dipping a gold electrode into a 4-NTP/dichloromethane solution (self-assembly method). The redox response of the electrode depended on the reduction stages of the nitro group in the 4-NTP molecule. When the 4-NTP on the electrode was partially reduced to 4-hydroxylaminothiophenol (Ar-NHOH) at -0.2 to -0.3 V vs SCE (the potential depends on the pH of the electrolyte solution), the electrode showed a pair of redox responses in an acidic aqueous solution. The responses are attributed to the redox cycling between 4-nitrosothiophenol (Ar-NO) and Ar-NHOH with two-electron and two-proton transfer.
Underpotential deposition (UPD) in electrochemistry can be used to form heterometal deposits on substrates at a monolayer level, altering the surface characteristics. For a monolayer of 4-nitrothiophenol (4-NTP) on a roughened Au substrate, the reduction and dimerization to 4,4′-dimercaptoazobenzene (DMAB) were monitored under conditions of Ag UPD using electrochemical surface-enhanced Raman spectroscopy (EC-SERS). Formation of DMAB was enhanced on the Ag surface deposited via UPD between the Au substrate and the 4-NTP layer. The structures of the 4-NTP layer and the plasmonic surface remained intact during Ag UPD[1-2].
References
[1] Misun Hong. "Underpotential Deposition of Silver on Gold for Surface Catalysis of Plasmon-Enhanced Reduction of 4-Nitrothiophenol." The Journal of Physical Chemistry C 125 30 (2021): 16569–16575.
[2] Hiromori Tsutsumi. "Electrochemical Behavior of a 4-Nitrothiophenol Modified Electrode Prepared by the Self-Assembly Method." Journal of Colloid and Interface Science 171 2 (1995): Pages 505-511.
[3] Jan Kozisek . "Plasmon-driven substitution of 4–mercaptophenylboronic acid to 4-nitrothiophenol monitored by surface-enhanced Raman spectroscopy." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 319 (2024): Article 124523.
[4] Satish C. Agarwal. “Reaction of epoxides with 4-nitrothiophenol. Its possible application for trapping and characterization of epoxides.” Environmental Science and Technology 14 10 (1980): 1249–1253.
4-Nitrothiophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Nitrothiophenol manufacturers
- Product
- 4-NITROTHIOPHENOL 1849-36-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-11
- Product
- 4-NITROTHIOPHENOL 1849-36-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 25kg
- Release date
- 2019-07-10