2-NITRO-5-THIOCYANATOBENZOIC ACID

Product Name: 2-NITRO-5-THIOCYANATOBENZOIC ACID
CAS No.: 30211-77-9
Chemical Name: 2-NITRO-5-THIOCYANATOBENZOIC ACID
Synonyms: NTCB;Nitrothiocyanobenzoic acid;2-NITRO-5-THIOCYANOBENZOIC ACID;2-nitro-5-thiocyanato-benzoicaci;2-NITRO-5-THIOCYANATOBENZOIC ACID;2-Nitro-5-thiocyanatobenzoicAcid>Benzoic acid,2-nitro-5-thiocyanato-;2-Nitro-5-thiocyanatobenzoic acid,98%;2-Nitro-5-thiocyanobenzoic acid, NTCB;2-Nitro-5-thiocyanatobenzoic acid powder
CBNumber: CB7706488
Molecular Formula: C8H4N2O4S
Formula Weight: 224.19
MOL File: 30211-77-9.mol

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2-NITRO-5-THIOCYANATOBENZOIC ACID Property

Melting point:: 156-157 °C(lit.)
Boiling point:: 449.0±40.0 °C(Predicted)
Density: 1.63
refractive index: 1.5690 (estimate)
Flash point:: 225.4℃
storage temp.: Inert atmosphere,2-8°C
solubility: DMF: 25 mg/ml; DMSO: 11 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): 0.3 mg/ml
pka: 1.75±0.25(Predicted)
form: powder
color: yellow
BRN: 2124001
InChI: InChI=1S/C8H4N2O4S/c9-4-15-5-1-2-7(10(13)14)6(3-5)8(11)12/h1-3H,(H,11,12)
InChIKey: NQUNIMFHIWQQGJ-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(SC#N)=CC=C1[N+]([O-])=O
EPA Substance Registry System: Benzoic acid, 2-nitro-5-thiocyanato- (30211-77-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 8-21
TSCA: TSCA listed
HS Code: 29309090
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N7009
Product name: 2-Nitro-5-thiocyanatobenzoic acid
Purity: powder
Packaging: 250mg
Price: $100.65
Updated: 2025/07/31

Sigma-Aldrich

Product number: N7009
Product name: 2-Nitro-5-thiocyanatobenzoic acid
Purity: powder
Packaging: 1g
Price: $291
Updated: 2025/07/31

TCI Chemical

Product number: N0516
Product name: 2-Nitro-5-thiocyanatobenzoic Acid
Purity: >97.0%(HPLC)(T)
Packaging: 1g
Price: $136
Updated: 2025/07/31

Cayman Chemical

Product number: 18236
Product name: 2-Nitro-5-thiocyanatobenzoic Acid
Purity: ≥98%
Packaging: 250mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 18236
Product name: 2-Nitro-5-thiocyanatobenzoic Acid
Purity: ≥98%
Packaging: 1g
Price: $121
Updated: 2024/03/01

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2-NITRO-5-THIOCYANATOBENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

yellow fine crystalline powder

Uses

2-Nitro-5-thiocyanatobenzoic acid (NTCB) is a highly reactive reagent that transfers its cyano group rapidly to a nucleophilic thiolate. 2-Nitro-5-thiocyanatobenzoic acid has been proposed as a reagent for converting thiol groups in proteins into their S-cyano derivatives[1][2].

Biological Activity

2-nitro-5-thiocyanatobenzoic acid (NTCB) is commonly used to cyanylate and cleave proteins at cysteine residues.

References

[1] Qiao Y, et al. Site-Specific Conversion of Cysteine in a Protein to Dehydroalanine Using 2-Nitro-5-thiocyanatobenzoic Acid. Molecules. 2021;26(9):2619. Published 2021 Apr 29. DOI:10.3390/molecules26092619
[2] Price NC. Alternative products in the reaction of 2-nitro-5-thiocyanatobenzoic acid with thiol groups. Biochem J. 1976;159(1):177-180. DOI:10.1042/bj1590177

2-NITRO-5-THIOCYANATOBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-NITRO-5-THIOCYANATOBENZOIC ACID Suppliers

Americas 1 Belgium 2 Canada 1 China 56 Europe 1 Germany 3 India 3 Japan 4 Poland 1 Russia 1 Switzerland 3 United Kingdom 3 United States 19 Global 98

MedBioPharmaceutical Technology Inc

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View Lastest Price from 2-NITRO-5-THIOCYANATOBENZOIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-NITRO-5-THIOCYANATOBENZOIC ACID 30211-77-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-07-18

Career Henan Chemical Co

Product: 4,4'-Dinitrostilbene-2,2'-disulfonic acid 30211-77-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10000KGS
Release date: 2019-12-27

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2-Nitro-5-thiocyanobenzoic acid, NTCB

Nitrothiocyanobenzoic acid

2-Nitro-5-thiocyanatobenzoic acid,98%

NTCB

2-nitro-5-thiocyanato-benzoicaci

2-NITRO-5-THIOCYANATOBENZOIC ACID

2-NITRO-5-THIOCYANOBENZOIC ACID

Benzoic acid,2-nitro-5-thiocyanato-

2-Nitro-5-thiocyanatobenzoicAcid&gt

2-Nitro-5-thiocyanatobenzoic acid powder

30211-77-9

O2NC6H3SCNCO2H

C8H4N2O4S

BioChemical

Enzymatic and Chemical Protein Cleavage

Proteomics and Protein Expression

Proteomics

Reagents for Chemical Cleavage of Proteins

Protection & Derivatization Reagents (for Synthesis)

Synthetic Organic Chemistry