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Methanesulfonamide

Product Name
Methanesulfonamide
CAS No.
3144-09-0
Chemical Name
Methanesulfonamide
Synonyms
METHANSULFONAMIDE;Mesyl amide;METHYL SULFONAMIDE;METHANESULPHONAMIDE;Methanesulfonic amide;A sulfonaMide;METHYLSULFAMIDE;Methylsulfonamid;Methanesulfomide;Methansulfonamid
CBNumber
CB2776813
Molecular Formula
CH5NO2S
Formula Weight
95.12
MOL File
3144-09-0.mol
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Methanesulfonamide Property

Melting point:
85-89 °C(lit.)
Boiling point:
208.2±23.0 °C(Predicted)
Density 
1.229 (estimate)
refractive index 
1.5130 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Slightly soluble in DMSO and methanol.
pka
10.87±0.60(Predicted)
form 
Crystals, Powder or Flakes
color 
White to yellow
BRN 
1740835
InChI
InChI=1S/CH5NO2S/c1-5(2,3)4/h1H3,(H2,2,3,4)
InChIKey
HNQIVZYLYMDVSB-UHFFFAOYSA-N
SMILES
CS(N)(=O)=O
CAS DataBase Reference
3144-09-0(CAS DataBase Reference)
NIST Chemistry Reference
Methane sulfonamide(3144-09-0)
EPA Substance Registry System
Methanesulfonamide (3144-09-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29350090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
64275
Product name
Methanesulfonamide
Purity
≥97.0% (CHN)
Packaging
10g
Price
$93.5
Updated
2025/07/31
Sigma-Aldrich
Product number
64275
Product name
Methanesulfonamide
Purity
≥97.0% (CHN)
Packaging
50g
Price
$151
Updated
2025/07/31
TCI Chemical
Product number
M0915
Product name
Methanesulfonamide
Purity
>98.0%(N)
Packaging
25g
Price
$41
Updated
2025/07/31
TCI Chemical
Product number
M0915
Product name
Methanesulfonamide
Purity
>98.0%(N)
Packaging
100g
Price
$123
Updated
2025/07/31
TCI Chemical
Product number
M0915
Product name
Methanesulfonamide
Purity
>98.0%(N)
Packaging
500g
Price
$494
Updated
2025/07/31
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Methanesulfonamide Chemical Properties,Usage,Production

Chemical Properties

White to yellow crystals, powder or flakes

Uses

Methanesulfonamide will react with thionyl chloride, cyanates, carbon disulfide and ketones and aldehydes to prepare pharmaceuticals, brightening agent and other target molecules. It is also used in biological studies to predict binding affinity and binding mode of protein ligand complexes.

Uses

  • Methanesulfonamide is used in the synthesis of important organic reagents such as N-(2-methylthio-1-p-toluenesufonyl)methanesulfonamide and tert-butyl ((2-(trimethylsilyl)ethyl)sulfonyl)carbamate.
  • It can be used as a source of nitrogen in the conversion of carboxylic acids to corresponding nitriles.
  • It is widely used as a reagent in the synthesis of medicinally important compounds such as derivatives of indole-N-acetamide, methanesulfonamide pyrimidine-substituted 3,5-dihydroxy-6-heptenoates and repertaxin.

Synthesis Reference(s)

Journal of the American Chemical Society, 90, p. 4096, 1968 DOI: 10.1021/ja01017a032
The Journal of Organic Chemistry, 60, p. 7682, 1995 DOI: 10.1021/jo00128a048
Tetrahedron Letters, 35, p. 7201, 1994 DOI: 10.1016/0040-4039(94)85360-6

Toxics Screening Level

The initial threshold screening level (ITSL) for methanesulfonamide is 44 μg/m3 (annual averaging time).

Methanesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Methanesulfonamide Suppliers

TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from Methanesulfonamide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Methanesulfonamide 3144-09-0
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-12-06
Langfang Hawk Techology & Development Co, Ltd.
Product
Methanesulfonamide 3144-09-0
Price
US $0.00-0.00/Kg/Drum
Min. Order
100g
Purity
>98.5%
Supply Ability
20tons
Release date
2019-07-05
Langfang Hawk Techology & Development Co, Ltd.
Product
Methanesulfonamide 3144-09-0
Price
US $0.00-0.00/Kg/Drum
Min. Order
100g
Purity
>98.5%
Supply Ability
20tons
Release date
2019-07-05

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