ChemicalBook > CAS DataBase List > Hydroxyzine dihydrochloride
Hydroxyzine dihydrochloride
- Product Name
- Hydroxyzine dihydrochloride
- CAS No.
- 2192-20-3
- Chemical Name
- Hydroxyzine dihydrochloride
- Synonyms
- orgatrax;Hydroxyzine 2HCl;QYS;Quies;Disron;Durrax;Quiess;alamon;neurolax;(S)-Hydroxyzine
- CBNumber
- CB2777401
- Molecular Formula
- C21H29Cl3N2O2
- Formula Weight
- 447.83
- MOL File
- 2192-20-3.mol
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Hydroxyzine dihydrochloride Property
- Melting point:
- 190-192°C
- Flash point:
- 9℃
- storage temp.
- 2-8°C
- solubility
- H2O: soluble
- form
- powder
- color
- White to Off-White
- CAS DataBase Reference
- 2192-20-3(CAS DataBase Reference)
- EPA Substance Registry System
- Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride (2192-20-3)
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Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- WGK Germany
- 3
- RTECS
- KK2280000
- HS Code
- 29335990
- Toxicity
- LD50 in rats (mg/kg): 126 i.p.; 950 orally (Goldenthal)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H336May cause drowsiness or dizziness
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313IF exposed or concerned: Get medical advice/attention.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- H-124
- Product name
- Hydroxyzine dihydrochloride solution
- Purity
- 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $127
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 1333003
- Product name
- Hydroxyzine hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 500mg
- Price
- $436
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- PHR1607
- Product name
- Hydroxyzine dihydrochloride
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 1g
- Price
- $173
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- H8885
- Product name
- Hydroxyzine dihydrochloride
- Purity
- ≥98%
- Packaging
- 10g
- Price
- $116
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- H1435000
- Product name
- Hydroxyzine hydrochloride
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- h1435000
- Price
- $153
- Updated
- 2024/03/01
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Hydroxyzine dihydrochloride Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
Atarax,UCB,France,1956
Uses
Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.
Uses
Antihistaminic;H1 antogonist
Uses
Anti histamines
Uses
H1 receptor antagonist. Anxiolytic. Antihistaminic.
Manufacturing Process
A mixture of 0.1 mol of N-mono-1-p-chlorobenzohydrylpiperazine and 0.1 mol
of 1-chloro-2-(2-hydroxy-ethoxy)-ethane is heated for 3 hours to 150°C. The
mass is then taken up in 100 ml of benzene and 100 ml of a 10% aqueous
solution of NaOH; decanting takes place, and the benzene solution is washed
with water and the solvent is evaporated. Vacuum distilling of the residue
yields 1-p-chlorobenzohydryl-4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazine, BP
220°C/0.5 mm Hg.
The corresponding dihydrochloride is prepared by dissolving this base in about
twice its weight of alcohol, by treating it with excess of gaseous HCl and by
precipitating it with ether. The solvent is decanted and the residue, dissolved
in a minimum of alcohol, crystallizes on the addition of ether, MP 193°C.
brand name
Amplimexon (Amplimed).
Therapeutic Function
Tranquilizer
General Description
Hydroxyzine dihydrochloride is an antihistaminic drug and a member of the diphenylmethanes family. It exerts its action by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biochem/physiol Actions
Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.
Hydroxyzine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Hydroxyzine dihydrochloride manufacturers
Baoji Guokang Bio-Technology Co., Ltd.
- Product
- Hydroxyzine dihydrochloride 2192-20-3
- Price
- US $1910.00/Kg/Bag
- Min. Order
- 20KG
- Purity
- 99%
- Supply Ability
- 10T
- Release date
- 2021-06-03
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
- Product
- Hydroxyzine dihydrochloride 2192-20-3
- Price
- US $25.00/KG
- Min. Order
- 1KG
- Purity
- 0.99
- Supply Ability
- 5000kg/month
- Release date
- 2022-01-12
Hebei Guanlang Biotechnology Co., Ltd.
- Product
- Hydroxyzine dihydrochloride 2192-20-3
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2021-07-30
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