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H-PRO-LEU-GLY-NH2

Product Name
H-PRO-LEU-GLY-NH2
CAS No.
2002-44-0
Chemical Name
H-PRO-LEU-GLY-NH2
Synonyms
MELANOSTATIN;MIF-1;PRO-LEU-GLY-NH2;MIF-I;PLG-NH2;MSH-R-IF;MIF, AMIDE;Melanostatin I;H-PRO-LEU-GLY-NH2;PRO-LEU-GLY AMIDE
CBNumber
CB2779319
Molecular Formula
C13H24N4O3
Formula Weight
284.35
MOL File
2002-44-0.mol
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H-PRO-LEU-GLY-NH2 Property

Melting point:
122-123 °C(Solv: water (7732-18-5))
Boiling point:
626.2±55.0 °C(Predicted)
Density 
1.147±0.06 g/cm3(Predicted)
storage temp. 
-15°C
solubility 
≥59.1 mg/mL in DMSO; ≥50 mg/mL in EtOH; ≥50 mg/mL in H2O
pka
14.10±0.20(Predicted)
form 
Lyophilized powder
Water Solubility 
Soluble in water.
Sequence
H-Pro-Leu-Gly-NH2
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
1929
Product name
Melanocyte-stimulatinghormonereleaseinhibitingfactor
Packaging
10
Price
$72
Updated
2021/12/16
TRC
Product number
P756193
Product name
L-Prolyl-L-leucylglycinamide
Packaging
25mg
Price
$65
Updated
2021/12/16
Usbiological
Product number
255779
Product name
Melanocyte-stimulating hormone release inhibiting factor
Packaging
10mg
Price
$310
Updated
2021/12/16
Usbiological
Product number
M2868-72R
Product name
Melanocyte Stimulating Hormone Release Inhibiting Factor
Packaging
1mg
Price
$531
Updated
2021/12/16
Usbiological
Product number
M2868-72S
Product name
Melanocyte Stimulating Hormone Release Inhibiting Factor
Packaging
1mg
Price
$531
Updated
2021/12/16
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H-PRO-LEU-GLY-NH2 Chemical Properties,Usage,Production

Uses

L-Prolyl-L-leucylglycinamide is shown to be effective in treating human depression with greater efficacy and faster onset of action than traditional anti-depressants.Also, it is used in the synthesis of novel analogs to be tested for their ability to enhance the binding of [3H]-N-propylnorapomorphine to short isoform of human dopamine D2 receptors.

Definition

ChEBI: Melanostatin is an oligopeptide.

Biological Activity

melanocyte stimulating hormone release inhibiting factor,(c13h24n4o3), a tri-peptide with the sequence h2n-pro-leu-gly-amide, mw= 284.35. melanocyte-inhibiting factor (also known as pro-leu-gly-nh2, melanostatin, msh release-inhibiting hormone or mif-1) is an endogenous peptide fragment derived from cleavage of the hormone oxytocin, but having generally different actions in the body(1). mif-1 produces multiple effects, both blocking the effects of opioid receptor activation(2), while at the same time acting as a positive allosteric modulator of the d2 and d4 dopamine receptor subtypes, as well as inhibiting release of other neuropeptides such as alpha-msh, and potentiating melatonin activity(3). mif-1 is unusually resistant to metabolism in the bloodstream, and crosses the blood–brain barrier easily, though it is poorly active orally and is usually injected.figure1 formula of melanocyte stimulating hormone release inhibiting factor

in vivo

MIF-1 (Melanostatin, 1 mg/kg; i.p.; once, for 1 hour; male Wistar rats) modulates the analgesic effects and stress-induced analgesia (SIA)[1].
MIF-1 (Melanostatin, 1 mg/kg; i.p.; daily, for 8 weeks; Sprague-Dawley rats) attenuates spiroperidol-induced impairment of development of striatal dopamine D2 receptors in rats[3].

Animal Model:Male Wistar rats[1]
Dosage:1 mg/kg
Administration:Intraperitoneal injection; once, for 1 hour
Result:Decreased the analgesic effect. Increased the pain threshold for at least 1 h.
Animal Model:Sprague-Dawley rats[3]
Dosage:1 mg/kg
Administration:Intraperitoneal injection; daily, for 8 weeks
Result:Attenuated the ontogenic impairment of striatal D2 receptors that was produced by spiroperidol (HY-B1371) treatment.

storage

-20°C (desiccate)

References

1. Celis ME, Taleisnik S, Walter R (July 1971). "Regulation of formation and proposed structure of the factor inhibiting the release of melanocyte-stimulating hormone". Proceedings of the National Academy of Sciences of the United States of America 68 (7): 1428–33.2. Contreras PC, Takemori AE (June 1984). "Effect of prolyl-leucyl-glycinamide and alpha-melanocyte-stimulating hormone on levorphanol-induced analgesia, tolerance and dependence". Life Sciences 34 (26): 2559–66.3. Sandyk R (May 1990). "MIF-induced augmentation of melatonin functions: possible relevance to mechanisms of action of MIF-1 inmovement disorders". The International Journal of Neuroscience 52 (1-2): 59–65.

H-PRO-LEU-GLY-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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H-PRO-LEU-GLY-NH2 Suppliers

China 86 Germany 3 Switzerland 1 United Kingdom 3 United States 17 Global 110
ApexBio Technology LLC
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View Lastest Price from H-PRO-LEU-GLY-NH2 manufacturers

Dingwang Technology (Wuhan) Co., Ltd.
Product
MIF-1 (pro-Leu-Gly-NH2) 2002-44-0
Price
US $0.00/g
Min. Order
1g
Purity
99% min
Supply Ability
20 tons
Release date
2025-01-16
Shaanxi Dideu Medichem Co. Ltd
Product
H-PRO-LEU-GLY-NH2 2002-44-0
Price
US $0.10/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10
Release date
2024-07-14
Career Henan Chemical Co
Product
H-PRO-LEU-GLY-NH2 2002-44-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-13

2002-44-0, H-PRO-LEU-GLY-NH2Related Search:

Carbetocin Oxytocin free acid Oxytocin Z-PRO-LEU-GLY-NH2 H-TYR-PRO-LEU-GLY-NH2,TYR-PRO-LEU-GLY-NH2 CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 ACETATE SALT BIOTIN-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2,BIOTIN-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 (DISULFIDE BRIDGE: 1-6) H-PRO-LEU-GLY-NH2 H2O,L-PRO-LEU-GLY NH2 HEMIHYDRATE CYCLO(TYR-ILE-GLN-ASN-ASU)-PRO-LEU-GLY-NH2,TYR-ILE-GLN-ASN-ASU-PRO-LEU-GLY-NH2 H-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH-CH2CH2F N-(4-Oxo-4H-3,1-benzoxazin-2-yl)-Pro-Leu-Gly-NH2 PRO-LEU-GLY-NH2 1/2H2O Cys(Bzl)-Pro-Leu-Gly-NH2 Z–GLN–ASN–CYS(BZL)–PRO–LEU–GLY–NH2 H-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH-CH2CH2F, (DISULFIDE BOND) BOC-ASN-CYS(ACM)-PRO-LEU-GLY-NH2 H2O OXYTOCIN = H-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 DISULFIDE BOND CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 ACETATE SALT HYDRATE

  • MELANOCYTE STIMULATING HORMONE RELEASE INHIBITING FACTOR
  • MELANOCYTE STIMULATING HORMONE RELEASE INHIBITING FACTOR, AMIDE
  • MELANOCYTE STIMULATING HORMONE RELEASING FACTOR
  • MELANOSTATIN
  • H-PRO-LEU-GLY-NH2
  • L-Prolyl-L-leucylglycinamide, hemihydrate
  • L-prolyl-L-leucylglycinamide
  • MSH-RELEASE INHIBITING FACTOR
  • MSH RELEASE INHIBITING FACTOR, AMIDE
  • MIF-1
  • MIF, AMIDE
  • MIF-I
  • PRO-LEU-GLY AMIDE
  • PRO-LEU-GLY-NH2
  • PLG-NH2
  • MIF-I, Melanostatin, Melanotropin Release-Inhibiting Factor
  • Melanostatin, MIF-I, Oxytocin fragment 7-9
  • Melanocyte-stimulating hormone release inhibiting factor I
  • Melanocyte-stimulating hormone release-inhibiting factor I
  • Melanostatin I
  • MSH-release inhibiting factor I
  • PRO-LEU-GLY AMIDE;MIF-I;OXYTOCIN FRAGMENT 7-9
  • (2S)-N-[(1S)-1-[(2-amino-2-keto-ethyl)carbamoyl]-3-methyl-butyl]pyrrolidine-2-carboxamide
  • (2S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
  • (2S)-N-[(2S)-1-[(2-azanyl-2-oxo-ethyl)amino]-4-methyl-1-oxo-pentan-2-yl]pyrrolidine-2-carboxamide
  • MIF-1;MSH-R-IF;MELANOCYTE-STIMULATING HORMONE RELEASE-INHIBITING FACTOR
  • MSH-R-IF
  • (S)-N-((S)-1-((2-Amino-2-oxoethyl)amino)-4-methyl-1-oxopentan-2-yl)pyrrolidine-2-carboxamide
  • Glycinamide, L-prolyl-L-leucyl-
  • Melanocyte-stimulati
  • Oxytocin C-terminal tripeptide
  • Melanocyte-Stimulating Hormone-Release Inh,MSH Release Inhibiting Factor, amide
  • L-Prolyl-L-Leucyl-Glycinamide TFA salt
  • MIF-1 (pro-Leu-Gly-NH2)
  • 2002-44-0
  • C13H24N4O3
  • Cytokines, Growth Factors and Hormones
  • Pituitary Hormones
  • Oxytocin
  • Hormones
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • SignalTransduction
  • Melanocortin receptor
  • peptide
  • Elisa Kit-Mouse Elisa Kit