3,4-Dimethoxyphenylacetone
- Product Name
- 3,4-Dimethoxyphenylacetone
- CAS No.
- 776-99-8
- Chemical Name
- 3,4-Dimethoxyphenylacetone
- Synonyms
- Veratone;Weratone;Cucurbitone;Veratrum ketone;VERATRYL ACETONE;Veratryl-2-propanone;METHYL VERATRYL KETONE;Veratryl methyl ketone;Ranitidine Impurity 32;4-DiMethoxyphenyl)acetone
- CBNumber
- CB2779551
- Molecular Formula
- C11H14O3
- Formula Weight
- 194.23
- MOL File
- 776-99-8.mol
3,4-Dimethoxyphenylacetone Property
- Melting point:
- 136-139 °C
- Boiling point:
- 154-158 °C (12 mmHg)
- Density
- 1.115 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.5358(lit.)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- form
- clear liquid
- color
- Light yellow to Yellow to Orange
- Water Solubility
- Insoluble in water.
- BRN
- 1107410
- InChI
- InChI=1S/C11H14O3/c1-8(12)6-9-4-5-10(13-2)11(7-9)14-3/h4-5,7H,6H2,1-3H3
- InChIKey
- UMYZWICEDUEWIM-UHFFFAOYSA-N
- SMILES
- C(C1=CC=C(OC)C(OC)=C1)C(=O)C
- CAS DataBase Reference
- 776-99-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 3,4-Dimethoxyphenylacetone(776-99-8)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- V0052
- Product name
- 3,4-Dimethoxyphenylacetone
- Purity
- >97.0%(GC)
- Packaging
- 25mL
- Price
- $53
- Updated
- 2025/07/31
- Product number
- V0052
- Product name
- 3,4-Dimethoxyphenylacetone
- Purity
- >97.0%(GC)
- Packaging
- 500mL
- Price
- $527
- Updated
- 2025/07/31
- Product number
- J93080
- Product name
- 3,4-Dimethoxyphenylacetone
- Packaging
- 5g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- JK598394
- Product name
- (3,4-Dimethoxyphenyl)acetone
- Purity
- 97%
- Packaging
- 10g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 172592
- Product name
- 3,4-Dimethoxyphenylacetone
- Packaging
- 25g
- Price
- $38
- Updated
- 2021/12/16
3,4-Dimethoxyphenylacetone Chemical Properties,Usage,Production
Chemical Properties
CLEAR YELLOW TO BROWN LIQUID
Uses
3,4-Dimethoxyphenylacetone was used as starting material in the synthesis of α-methyl-dopa, an important nonproteogenic α-amino acid for pharmaceutical applications. 3,4-Dimethoxyphenylacetone undergoes asymmetric amination catalyzed by Brevibacterium linens IFO 12141 strain to yield corresponding optically active amine
Synthesis Reference(s)
Chemistry Letters, 5, p. 1239, 1976
The Journal of Organic Chemistry, 29, p. 1424, 1964 DOI: 10.1021/jo01029a039
Synthesis
93-15-2
776-99-8
GENERAL METHOD: To a THF/water (4:1, 15 mL) solution of methyl eugenol (1 mmol) was added 10% Pd/C (0.05 mmol) and KBrO3 (3 mmol). The reaction mixture was heated to reflux temperature. The reaction progress was monitored by TLC. After completion of the reaction, the mixture was diluted with water and filtered through Whatman 40 filter paper. The filtrate was extracted with ethyl acetate and the organic layers were combined. The organic layers were washed sequentially with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography to give 3,4-dimethoxypropiophenone.
References
[1] Tetrahedron Letters, 2013, vol. 54, # 19, p. 2293 - 2295
[2] Tetrahedron Letters, 2009, vol. 50, # 24, p. 2893 - 2894
[3] Synthesis, 1992, # 12, p. 1229 - 1231
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1975, p. 1548 - 1551
3,4-Dimethoxyphenylacetone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,4-Dimethoxyphenylacetone manufacturers
- Product
- 3,4-Dimethoxyphenylacetone 776-99-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-13
- Product
- 3,4-Dimethoxyphenylacetone 776-99-8
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2023-09-22
- Product
- 3,4-Dimethoxyphenylacetone 776-99-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10ton
- Release date
- 2024-07-23