ChemicalBook > CAS DataBase List > Desonide

Desonide

Product Name
Desonide
CAS No.
638-94-8
Chemical Name
Desonide
Synonyms
Tridesilon;PREDNACINOLONE;d-2083;Topifug;The Ned;DESONIDE;Locapred;Desonade;steroderm;Be Consolide
CBNumber
CB2783466
Molecular Formula
C24H32O6
Formula Weight
416.51
MOL File
638-94-8.mol
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Desonide Property

Melting point:
272-274?C
Boiling point:
580.1±50.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMF (Slightly, Sonicated), DMSO (Sparingly), Methanol (Slightly, Heated)
form 
Solid
pka
12.87±0.10(Predicted)
color 
White to Off-White
CAS DataBase Reference
638-94-8(CAS DataBase Reference)
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Safety

HS Code 
2937290000
Toxicity
LD50 in rats (mg/kg): 93 s.c. (Phillips)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P314Get medical advice/attention if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS021596
Product name
Desonide
Packaging
50MG
Price
$37.8
Updated
2022/05/15
TCI Chemical
Product number
D5578
Product name
Desonide
Packaging
250MG
Price
$27
Updated
2024/03/01
TCI Chemical
Product number
D5578
Product name
Desonide
Packaging
1G
Price
$75
Updated
2024/03/01
Cayman Chemical
Product number
21368
Product name
Desonide
Purity
≥98%
Packaging
50mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
21368
Product name
Desonide
Purity
≥98%
Packaging
100mg
Price
$176
Updated
2024/03/01
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Desonide Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Tridesilon,Dome,US,1972

Uses

Desonide(Budesonide EP Impurity F) is an impurity of Budesonide (B689490), an anti-inflammatory.

Uses

antifungal

Uses

Anti-inflammatory. Desonide has also been found as an impurity in budesonide (B689490).

Definition

ChEBI: Triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders.

Indications

Desonide (DesOwen, Tridesilon) is a synthetic corticosteroid.

Manufacturing Process

Preparation of 11β,21-Dihydroxy-16α,17α-Isopropylidenedioxy-1,4- Pregnadiene-3,20-Dione: A solution of 11β,16α,17α,21-tetrahydroxy-1,4- pregnadiene-3,20-dione (40 mg) in acetone (10 ml) containing hydrochloric acid (three drops; d 1.19) is boiled 3n the steam bath for two minutes and then allowed to stand for eighteen hours at room temperature. The reaction mixture is diluted with water (50 ml) and extracted with chloroform (3x25 ml), the combined extracts then being washed with water (30 ml) and dried over anhydrous sodium sulfate. The residue obtained by removal of solvent crystallized from ethyl acetate-petroleum ether as small plates (25 mg), melting point 257°-260°C.

brand name

Desowen (Galderma); Tridesilon (Perrigo).

Therapeutic Function

Antiinflammatory

Desonide Preparation Products And Raw materials

Raw materials

Preparation Products

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Desonide Suppliers

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View Lastest Price from Desonide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Desonide 638-94-8
Price
US $0.00/g
Min. Order
10g
Purity
97.0-103.0%,USP30
Supply Ability
50kg/month
Release date
2021-06-19
Wuhan Senwayer Century Chemical Co.,Ltd
Product
Desonide 638-94-8
Price
US $380.00/gram
Min. Order
100gram
Purity
99% HPLC
Supply Ability
20 tons
Release date
2022-10-21
Zibo Hangyu Biotechnology Development Co., Ltd
Product
Desonide 638-94-8
Price
US $70.00-700.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-06

638-94-8, DesonideRelated Search:

(r)-budesonide Ciclesonide 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 14,15-Dehydro Budesonide 9α-BroMobudesonide 16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers) LY2228820 Meprednisone Dienogestrel Clopidogrel Bisulfate LY 2157299 Budesonide Di-Norbudesonide (Mixture of DiastereoMers) 9,11-Anhydrobudesonide 21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione (16α)-16,17-[Butylidenebis(oxy)]-21-hydroxypregna-1,4-diene-3,11,20-trione 1,2-Dehydrobudesonide Budesonide Sulfate SodiuM (Mixture of DiastereoMers)

  • PREDNACINOLONE
  • DESONIDE
  • 1,4-PREGNADIEN-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE 16,17-ACETONIDE
  • (11b,16a)-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-pregna-1,4-diene-3,20-dione
  • 16-alpha-hydroxyprednisole-16,17-acetonide
  • 17-acetonide,16-alpha-hydroxy-prednisolone-1
  • d-2083
  • steroderm
  • Desonidemicro
  • (11β,16α)-11,21-Dihydroxy-16,17-[(1-Methylethylidene)bis(oxy)]pregna -1,4-diene-3,20-dione
  • 16α-Hydroxyprednisolone Acetonide
  • (11,16a)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
  • 16a-Hydroxyprednisolone Acetonide
  • Locapred
  • Topifug
  • Tridesilon
  • Be Consolide
  • 16a-Hydroxyprednisole-16,17-acetonide
  • Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11b,16a)-
  • Desonide (250 mg)
  • Desonide, >=99%
  • Budesonide EP Impurity F(Desonide)
  • 16α,17-[1-methylethylidenebis(oxy)]-11β,21-dihydroxypregna-1,4-diene-3,20-dione
  • Budesonide impurity F
  • Budesonide Impurity F (Desonide)
  • DesonideBiocar
  • Budesonide Impurity 6(Budesonide EP Impurity F)
  • Budesonide iMpurit F
  • Budesonide EP Impurity F
  • 11beta,21-Dihydroxy-16alpha,17alpha-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11β,16α)-
  • Desonide Solution in Acetonitrile, 100μg/mL
  • (6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one
  • (11beta,16alpha)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
  • Budesonide Acetonide
  • Desonide USP/EP/BP
  • DesonideQ: What is Desonide Q: What is the CAS Number of Desonide Q: What is the storage condition of Desonide
  • 16a,17-[1-Methylethylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
  • Desonide (1173304)
  • The Ned
  • -Amino-2-methyl-283H-tetrazole
  • Desonide (Budesonide acetonide)
  • API Steriods Desonide Powder Dosage Usage Effect and Benefit
  • 16α,17-[1-methylethylidenebis(oxy)]-11β,21-dihydroxypregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11β,16α)-
  • Desonide (Budesonide EP Impurity F)
  • 1, 4-PREGNADIEN-11β, 16α, 17, 21-TETROL-3, 20-DIONE 16, 17-ACETONIDE
  • Desonide/(6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one
  • Desonade
  • (6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-Hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one
  • Desonide/(6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one
  • Desonide EP Impurity-E
  • 16alpha,17-[1-Methylethylidenebis(oxy)]-11beta,21-dihydroxypregna-1,4-diene-3,20-dione (Desonide)
  • Desonide, 10 mM in DMSO
  • 638-94-8
  • C24H32O6
  • SPORANOX
  • Hormone Drugs