ChemicalBook > CAS DataBase List > 5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID

5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID

Product Name
5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID
CAS No.
3757-53-7
Chemical Name
5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID
Synonyms
5-Methylpyrrole-2-Carboxylic Acid;5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID;1H-Pyrrole-2-carboxylic acid, 5-methyl-
CBNumber
CB2803461
Molecular Formula
C6H7NO2
Formula Weight
125.13
MOL File
3757-53-7.mol
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5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID Property

Melting point:
137-138 °C
Boiling point:
326.3±22.0 °C(Predicted)
Density 
1.295±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
4.73±0.10(Predicted)
Appearance
Light yellow to light brown Solid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
M339113
Product name
5-Methylpyrrole-2-carboxylicAcid
Packaging
250mg
Price
$65
Updated
2021/12/16
AK Scientific
Product number
4808AB
Product name
5-Methyl-1H-pyrrole-2-carboxylicacid
Packaging
25g
Price
$1092
Updated
2021/12/16
Apolloscientific
Product number
OR962602
Product name
5-Methyl-1H-pyrrole-2-carboxylicacid
Purity
98%
Packaging
1g
Price
$160
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0299038
Product name
5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID
Purity
95.00%
Packaging
5MG
Price
$498.59
Updated
2021/12/16
Apolloscientific
Product number
OR962602
Product name
5-Methyl-1H-pyrrole-2-carboxylicacid
Purity
98%
Packaging
5g
Price
$565
Updated
2021/12/16
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5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

5-Methylpyrrole-2-carboxylic Acid is a useful reactant in preparation and biological evaluation of coumarin-carboxylic acids as inhibitors of gyrase B.

Synthesis

3284-51-3

3757-53-7

Ethyl 5-methyl-1H-pyrrole-2-carboxylate (400 mg, 2.61 mmol) was dissolved in a mixed solvent of dioxane/water/ethanol (10 mL/1 mL/2 mL) with reference to the method of Curran, T.; Keaney, M. (J. Org. Chem., 61(25), 1996, 9068-9069). Sodium hydroxide (520 mg, 13 mmol) was added and the reaction was refluxed for 3 hours. After completion of the reaction, the solvent was removed under reduced pressure. The crude product was dissolved in water and extracted with dichloromethane (DCM). The aqueous phase was adjusted to pH 1 with 1N hydrochloric acid and the organic and aqueous phases were separated. The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude 5-methyl-1H-pyrrole-2-carboxylic acid, which can be used in the next reaction without further purification. Yield: quantitative; LCMS (retention time): 2.51 min (Method D); MS (ES+) m/z: 126.03.

References

[1] Patent: WO2006/123257, 2006, A2. Location in patent: Page/Page column 57-58
[2] Tetrahedron Letters, 2003, vol. 44, # 1, p. 61 - 63
[3] Chemistry - A European Journal, 2017, vol. 23, # 14, p. 3300 - 3320
[4] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 5, p. 553 - 557
[5] Annali di Chimica (Rome, Italy), 1956, vol. 46, p. 847,854

5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID Suppliers

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View Lastest Price from 5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
5-Methyl-1H-pyrrole-2-carboxylic acid 3757-53-7
Price
US $1.10-9.90/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kg
Release date
2025-08-14
Shaanxi Dideu Medichem Co. Ltd
Product
5-Methylpyrrole-2-Carboxylic Acid 3757-53-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20t
Release date
2024-07-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID 3757-53-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

3757-53-7, 5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACIDRelated Search:

5-Methyl-1H-pyrazole-3-carboxylic acid ETHYL 3,4,5-TRIMETHYLPYRROLE-2-CARBOXYLATE 4-(Ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid Ethyl 2,4-dimethyl-5-(ethoxycarbonyl)-3-pyrrolepropionate 3-ACETYL-2,4-DIMETHYL-5-CARBETHOXYPYRROLE ETHYL 4-ETHYL-3,5-DIMETHYL-1H-PYRROLE-2-CARBOXYLATE Pyrroloquinoline quinone Diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate Ethyl 3,5-dimethyl-1H-pyrrole-2-carboxylate TERT-BUTYL 3,4,5-TRIMETHYL-2-PYRROLECARBOXYLATE ETHYL 4-FORMYL-3,5-DIMETHYL-1H-PYRROLE-2-CARBOXYLATE 5-FORMYL-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLIC ACID DIETHYL ESTER METHYL 5-(BENZYLOXYCARBONYL)-2,4-DIMETHYL-3-PYRROLEPROPIONATE ethyl 4-(2-methoxycarbonylethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate TERT-BUTYL 4-ACETYL-3,5-DIMETHYL-2-PYRROLECARBOXYLATE 4-(2-CARBOXYETHYL)-3,5-DIMETHYLPYRROLE-2-CARBOXYLIC ACID, ETHYL ETHER 4-ACETYL-3,5-DIMETHYL-1H-PYRROLE-2-CARBOXYLIC ACID 5-BROMOMETHYL-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLIC ACID DIETHYL ESTER

  • 1H-Pyrrole-2-carboxylic acid, 5-methyl-
  • 5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID
  • 5-Methylpyrrole-2-Carboxylic Acid
  • 3757-53-7