5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID
- Product Name
- 5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID
- CAS No.
- 3757-53-7
- Chemical Name
- 5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID
- Synonyms
- 5-Methylpyrrole-2-Carboxylic Acid;5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID;1H-Pyrrole-2-carboxylic acid, 5-methyl-
- CBNumber
- CB2803461
- Molecular Formula
- C6H7NO2
- Formula Weight
- 125.13
- MOL File
- 3757-53-7.mol
5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID Property
- Melting point:
- 137-138 °C
- Boiling point:
- 326.3±22.0 °C(Predicted)
- Density
- 1.295±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.73±0.10(Predicted)
- Appearance
- Light yellow to light brown Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M339113
- Product name
- 5-Methylpyrrole-2-carboxylicAcid
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 4808AB
- Product name
- 5-Methyl-1H-pyrrole-2-carboxylicacid
- Packaging
- 25g
- Price
- $1092
- Updated
- 2021/12/16
- Product number
- OR962602
- Product name
- 5-Methyl-1H-pyrrole-2-carboxylicacid
- Purity
- 98%
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- CHM0299038
- Product name
- 5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.59
- Updated
- 2021/12/16
- Product number
- OR962602
- Product name
- 5-Methyl-1H-pyrrole-2-carboxylicacid
- Purity
- 98%
- Packaging
- 5g
- Price
- $565
- Updated
- 2021/12/16
5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
5-Methylpyrrole-2-carboxylic Acid is a useful reactant in preparation and biological evaluation of coumarin-carboxylic acids as inhibitors of gyrase B.
Synthesis
3284-51-3
3757-53-7
Ethyl 5-methyl-1H-pyrrole-2-carboxylate (400 mg, 2.61 mmol) was dissolved in a mixed solvent of dioxane/water/ethanol (10 mL/1 mL/2 mL) with reference to the method of Curran, T.; Keaney, M. (J. Org. Chem., 61(25), 1996, 9068-9069). Sodium hydroxide (520 mg, 13 mmol) was added and the reaction was refluxed for 3 hours. After completion of the reaction, the solvent was removed under reduced pressure. The crude product was dissolved in water and extracted with dichloromethane (DCM). The aqueous phase was adjusted to pH 1 with 1N hydrochloric acid and the organic and aqueous phases were separated. The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude 5-methyl-1H-pyrrole-2-carboxylic acid, which can be used in the next reaction without further purification. Yield: quantitative; LCMS (retention time): 2.51 min (Method D); MS (ES+) m/z: 126.03.
References
[1] Patent: WO2006/123257, 2006, A2. Location in patent: Page/Page column 57-58
[2] Tetrahedron Letters, 2003, vol. 44, # 1, p. 61 - 63
[3] Chemistry - A European Journal, 2017, vol. 23, # 14, p. 3300 - 3320
[4] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 5, p. 553 - 557
[5] Annali di Chimica (Rome, Italy), 1956, vol. 46, p. 847,854
5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID manufacturers
- Product
- 5-Methyl-1H-pyrrole-2-carboxylic acid 3757-53-7
- Price
- US $1.10-9.90/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-14
- Product
- 5-Methylpyrrole-2-Carboxylic Acid 3757-53-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20t
- Release date
- 2024-07-14
- Product
- 5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID 3757-53-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10