Xentuzumab

Product Name: Xentuzumab
CAS No.: 1417158-65-6
Chemical Name: Xentuzumab
Synonyms: BI 836845;Xentuzumab;Xentuzumab (anti-IGF1);Research Grade Xentuzumab
CBNumber: CB28080967
Formula Weight: 0
MOL File: Mol file

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Xentuzumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Xentuzumab Chemical Properties,Usage,Production

Uses

Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a human monoclonal antibody that targets IGF ligands IGF1 and IGF2. Xentuzumab inhibits both of IGF1 and IGF2 growth-promoting signalling and suppresses AKT activation[1].

in vivo

Xentuzumab (200 mg/kg i.p., once weekly for 10 weeks) in inhibits tumor growth in LuCaP 96CR patient-derived xenograft model in mice^[1].

Animal Model:	Fox Chase CB17 severe combined immunodeficiency (SCID; CB17/lcr-Prkdc scid/lcrlcoCrl) male mice with LuCaP 96CR cell (s.c.)^[1]
Dosage:	200 mg/kg
Administration:	Intraperitoneal injection; once weekly for 10 weeks; sacrificed 6 hours after the last dose
Result:	Resulted in significant reductions in tumor volume.

References

[1] Weyer-Czernilofsky U, et al. Antitumor Activity of the IGF-1/IGF-2-Neutralizing Antibody Xentuzumab (BI 836845) in Combination with Enzalutamide in Prostate Cancer Models. Mol Cancer Ther. 2020 Apr;19(4):1059-1069. DOI:10.1158/1535-7163.MCT-19-0378

Xentuzumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Xentuzumab Suppliers

China 18 United States 2 Global 20

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
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Guangzhou Hongyuan Chemical Co.,Ltd

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Wuhan Chemstan Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Biolab Reagents

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Wuhan Jingkangen Biomedical Technology Co., Ltd

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Shanghai Yifei Biotechnology Co. , Ltd.

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Shanghai Aladdin Biochemical Technology Co.,Ltd.

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1417158-65-6, XentuzumabRelated Search:

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Xentuzumab

Research Grade Xentuzumab

Xentuzumab (anti-IGF1)

BI 836845

1417158-65-6