ChemicalBook > CAS DataBase List > Xentuzumab
Xentuzumab
- Product Name
- Xentuzumab
- CAS No.
- 1417158-65-6
- Chemical Name
- Xentuzumab
- Synonyms
- BI 836845;Xentuzumab;Xentuzumab (anti-IGF1);Research Grade Xentuzumab
- CBNumber
- CB28080967
- Formula Weight
- 0
- MOL File
- Mol file
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Xentuzumab Property
- form
- Liquid
- color
- Colorless to light yellow
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Xentuzumab Chemical Properties,Usage,Production
Uses
Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a human monoclonal antibody that targets IGF ligands IGF1 and IGF2. Xentuzumab inhibits both of IGF1 and IGF2 growth-promoting signalling and suppresses AKT activation[1].
in vivo
Xentuzumab (200 mg/kg i.p., once weekly for 10 weeks) in inhibits tumor growth in LuCaP 96CR patient-derived xenograft model in mice[1].
| Animal Model: | Fox Chase CB17 severe combined immunodeficiency (SCID; CB17/lcr-Prkdc scid/lcrlcoCrl) male mice with LuCaP 96CR cell (s.c.)[1] |
| Dosage: | 200 mg/kg |
| Administration: | Intraperitoneal injection; once weekly for 10 weeks; sacrificed 6 hours after the last dose |
| Result: | Resulted in significant reductions in tumor volume. |
References
[1] Weyer-Czernilofsky U, et al. Antitumor Activity of the IGF-1/IGF-2-Neutralizing Antibody Xentuzumab (BI 836845) in Combination with Enzalutamide in Prostate Cancer Models. Mol Cancer Ther. 2020 Apr;19(4):1059-1069. DOI:10.1158/1535-7163.MCT-19-0378
Xentuzumab Preparation Products And Raw materials
Raw materials
Preparation Products
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Xentuzumab Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
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