Rozanolixizumab
- Product Name
- Rozanolixizumab
- CAS No.
- 1584645-37-3
- Chemical Name
- Rozanolixizumab
- Synonyms
- UCB7665;UCB-7665;Rozanolixizumab;Rozanolixizumab (anti-FCGRT);Research Grade Rozanolixizumab;Research Grade Rozanolixizumab(DHF14602)
- CBNumber
- CB28080992
- Formula Weight
- 0
- MOL File
- Mol file
Rozanolixizumab Property
- storage temp.
- Store at -20°C
- form
- Liquid
- color
- Colorless to light yellow
Rozanolixizumab Chemical Properties,Usage,Production
Uses
Rozanolixizumab (UCB7665), a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P), is used to the research of reducing pathogenic IgG in autoimmune and alloimmune diseases[1].
in vivo
Intravenous (IV) rozanolixizumab dosing in cynomolgus monkeys demonstrated non-linear pharmacokinetics indicative of target-mediated drug disposition; single IV rozanolixizumab doses (30 mg/kg) in cynomolgus monkeys reduced plasma IgG concentration by 69% by Day 7 post-administration. Daily IV administration of rozanolixizumab (initial 30 mg/kg loading dose; 5 mg/kg daily thereafter) reduced plasma IgG concentrations in all cynomolgus monkeys, with low concentrations maintained throughout the treatment period (42 days)[1].
References
[1] Smith B, et al. Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration. MAbs. 2018;10(7):1111-1130. DOI:10.1080/19420862.2018.1505464
Rozanolixizumab Preparation Products And Raw materials
Raw materials
Preparation Products
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