Tislelizumab

Product Name: Tislelizumab
CAS No.: 1858168-59-8
Chemical Name: Tislelizumab
Synonyms: Tislelizumab;Tislelizumab (anti-PDCD1);Research Grade Tislelizumab;Research Grade Tislelizumab(DHH02206)
CBNumber: CB28081045
Formula Weight: 0
MOL File: Mol file

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Tislelizumab Property

storage temp.: Store at -20°C
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Tislelizumab Chemical Properties,Usage,Production

Uses

Tislelizumab is a monoclonal antibody that specifically binds to programmed cell death receptor 1 (PD-1), blocking its interaction with programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2). Tislelizumab can reactivate immune cells such as T lymphocytes and enhance anti-tumor activity. Tislelizumab can be used for the research of a variety of tumors including typical Hodgkin's lymphoma, urothelial carcinoma, non-small cell lung cancer and hepatocellular carcinoma[1][2][3].

in vivo

Tislelizumab (10 mg/kg; Intraperitoneal injection; Once a week; 4 weeks) has significant antitumor effect in the B16F10 melanoma mouse model^[2].

Animal Model:	B16F10/GM-CSF tumor cells treated hPD-1 C57BL/6 transgenic mice^[2]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection (i.p.); once a week for 4 weeks.
Result:	Exerted remarkable antitumor efficacy, resulting in approximate 86.7% tumor growth inhibition.

References

[1] Jie Wang, et al. Tislelizumab Plus Chemotherapy vs Chemotherapy Alone as First-line Treatment for Advanced Squamous Non-Small-Cell Lung Cancer: A Phase 3 Randomized Clinical Trial. JAMA Oncol. 2021 May 1;7(5):709-717. DOI:10.1001/jamaoncol.2021.0366
[2] Hong Y, et al. Tislelizumab uniquely binds to the CC' loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage. FEBS Open Bio. 2021 Mar;11(3):782-792. DOI:10.1002/2211-5463.13102
[3] Zhu K, et al. Expression of HER2 in high-grade urothelial carcinoma based on Chinese expert consensus and the clinical effects of disitamab vedotin-tislelizumab combination therapy in the treatment of advanced patients. Front Pharmacol. 2024 Feb 22;15:1355081. DOI:10.3389/fphar.2024.1355081

Tislelizumab Preparation Products And Raw materials

Raw materials

Preparation Products

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1858168-59-8, TislelizumabRelated Search:

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Tislelizumab

Research Grade Tislelizumab(DHH02206)

Research Grade Tislelizumab

Tislelizumab (anti-PDCD1)

1858168-59-8