Sonelokimab
- Product Name
- Sonelokimab
- CAS No.
- 1414386-05-2
- Chemical Name
- Sonelokimab
- Synonyms
- Sonelokimab;Research Grade Sonelokimab;Research Grade Sonelokimab(DHH28808)
- CBNumber
- CB28081191
- Formula Weight
- 0
- MOL File
- Mol file
Sonelokimab Property
- form
- Liquid
- color
- Colorless to light yellow
Sonelokimab Chemical Properties,Usage,Production
Uses
Sonelokimab (ALX 0761) is a trivalent bispecific nanobody composed of camel derived humanized IL-17F antibodies, IL-17A/F antibodies, and serum albumin VHH antibodies. Sonelokimab can prolong the plasma half-life by binding to human serum albumin. Sonelokimab can be used for research on rheumatoid arthritis and psoriasis[1][2][3][4].
in vivo
Sonelokimab (2.8 and 10 mg/kg, s.c., weekly intervals for 8 consecutive weeks) reduces IL-15, IL-6, MMP-3 and TNF-α expression and demonstrates the potential preventive effect of arthritis in a collagen-induced arthritis model in cynomolgus monkey[4].
| Animal Model: | A collagen-induced arthritis model in cynomolgus monkey[4] |
| Dosage: | 2.8 and 10 mg/kg |
| Administration: | weekly intervals for 8 consecutive weeks |
| Result: | Significantly improved X-ray score B and the arthritis score in a collagen-induced arthritis model in cynomolgus monkey. |
IC 50
IL-17A; IL-17F
References
[1] Torres T, et al. A revolutionary therapeutic approach for psoriasis: bispecific biological agents. Expert Opin Investig Drugs. 2016 Jul;25(7):751-4. DOI:10.1080/13543784.2016.1187130
[2] Rossotti MA, et al. Immunogenicity and humanization of single-domain antibodies. FEBS J. 2022 Jul;289(14):4304-4327. DOI:10.1111/febs.15809
[3] Gao W, et al. Comparation of time-course, dose-effect, influencing factors and adverse events of biologics in the treatment of adults with moderate to severe plaque psoriasis. Front Immunol. 2023 May 25;14:1151977. DOI:10.3389/fimmu.2023.1151977
[4] Vanheusden K, et al. Pre-clinical proof-of-concept of ALX-0761, a Nanobody? neutralizing both IL-17A and F in a cynomolgus monkey collagen induced arthritis model[C]//ARTHRITIS AND RHEUMATISM. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: Wiley-Blackwell, 2013, 65: S543-S543.
Sonelokimab Preparation Products And Raw materials
Raw materials
Preparation Products
Sonelokimab Suppliers
- Tel
- 027-65317797 15926423062
- Fax
- QQ：422450190
- 422450190@qq.com
- Country
- China
- ProdList
- 10308
- Advantage
- 58
- Tel
- 027-65279366 18108604356
- products@biolabreagent.com
- Country
- China
- ProdList
- 9868
- Advantage
- 58
- Tel
- 13720134139 086-15871494362 13720134139
- orders@jknbiochem.com
- Country
- China
- ProdList
- 6762
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com
- Country
- China
- ProdList
- 11973
- Advantage
- 58
- Tel
- 027-87008169 17762441161
- info@atagenix.com
- Country
- China
- ProdList
- 10001
- Advantage
- 58
- Tel
- 33175446423
- support@antibodysystem.com
- Country
- China
- ProdList
- 6739
- Advantage
- 58
- Tel
- 51288865780
- sales@biosynth.com
- Country
- China
- ProdList
- 6051
- Advantage
- 58
- Tel
- 9785721070
- info@cellsciences.com
- Country
- China
- ProdList
- 6308
- Advantage
- 58
- Tel
- 18312220236
- Country
- CHINA
- ProdList
- 178
- Advantage
- 58