2-BROMO-6-ETHOXYCARBONYLBENZOTHIAZOLE
Uses- Product Name
- 2-BROMO-6-ETHOXYCARBONYLBENZOTHIAZOLE
- CAS No.
- 99073-88-8
- Chemical Name
- 2-BROMO-6-ETHOXYCARBONYLBENZOTHIAZOLE
- Synonyms
- 2-BROMO-6-ETHOXYCARBONYLBENZOTHIAZOLE;2-BROMOBENZOTHIAZOLE-6-CARBOXYLIC ACID;Ethyl 2-bromo-6-benzothiazolecarboxylate;Ethyl 2-bromobenzothiazole-6-carboxylate;ethyl 2-bromobenzo[d]thiazole-6-carboxylate;ethyl 2-broMo-1,3-benzothiazole-6-carboxylate;2-BroMo-benzothiazole-6-carboxylic acid ethyl ester;6-Benzothiazolecarboxylic acid, 2-bromo-, ethyl ester;2-Bromo-1,3-benzothiazole-6-carboxylic acid ethyl ester;JR-14054, Ethyl 2-bromobenzo[d]thiazole-6-carboxylate, 95%
- CBNumber
- CB2814401
- Molecular Formula
- C10H8BrNO2S
- Formula Weight
- 286.14
- MOL File
- 99073-88-8.mol
2-BROMO-6-ETHOXYCARBONYLBENZOTHIAZOLE Property
- Boiling point:
- 377.6±34.0 °C(Predicted)
- Density
- 1.618±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- -1.37±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- RIDADR
- UN2811
- HS Code
- 2934208090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- E900638
- Product name
- Ethyl2-Bromo-6-benzothiazolecarboxylate
- Packaging
- 2.5g
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 072201
- Product name
- Ethyl 2-bromo-6-benzothiazolecarboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $416
- Updated
- 2021/12/16
- Product number
- W9861
- Product name
- Ethyl2-bromo-6-benzothiazolecarboxylate
- Packaging
- 25g
- Price
- $957
- Updated
- 2021/12/16
- Product number
- HCH0050748
- Product name
- 2-BROMO-6-ETHOXYCARBONYLBENZOTHIAZOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1034.88
- Updated
- 2021/12/16
- Product number
- 072201
- Product name
- Ethyl 2-bromo-6-benzothiazolecarboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1197
- Updated
- 2021/12/16
2-BROMO-6-ETHOXYCARBONYLBENZOTHIAZOLE Chemical Properties,Usage,Production
Uses
2-Bromobenzothiazole-6-carboxylic acid ethyl ester can be used as a pharmaceutical synthesis intermediate.
Synthesis
50850-93-6
99073-88-8
General procedure for the synthesis of ethyl 2-bromobenzothiazole-6-carboxylate from ethyl 2-aminobenzothiazole-6-carboxylate: commercially available ethyl 2-aminobenzothiazole-6-carboxylate (10 g, 45 mmol) was dissolved in acetonitrile (40 mL), and this solution was then added to a solution containing copper(II) bromide (12 g, 54 mmol) and tert-butyl nitrite (9 mL, 75 mmol) in a solution of acetonitrile (100 mL). The reaction was carried out at room temperature and under nitrogen protection with continuous stirring for 45 min. Upon completion of the reaction, the reaction mixture was diluted with 1N HCl (300 mL) and subsequently extracted with dichloromethane (3 x 300 mL). The organic extracts were combined, washed with water (300 mL), dried with anhydrous magnesium sulfate, filtered through a silica gel plug, and finally the solvent was removed under reduced pressure to afford the target product ethyl 2-bromobenzothiazole-6-carboxylate (Step 1) as an off-white solid (11.5 g, 89% yield). The product was characterized by 1H NMR (CDCl3): δ 1.40 (t, 3H), 4.40 (q, 2H), 8.00 (d, 1H), 8.20 (d, 1H), 8.60 (s, 1H).
References
[1] Patent: EP2766359, 2016, B1. Location in patent: Paragraph 0319
[2] Patent: WO2004/63155, 2004, A1. Location in patent: Page 148-149
[3] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 6, p. 1874 - 1879
[4] Yakugaku Zasshi, 1958, vol. 78, p. 437
[5] Chem.Abstr., 1958, p. 14589
2-BROMO-6-ETHOXYCARBONYLBENZOTHIAZOLE Preparation Products And Raw materials
Raw materials
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